Journal article
Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis
Abstract
AIM: Apoptosis is one of the most important mechanisms underlying renal tubulointerstitial fibrosis. We identified a role of protein Peroxiredoxin 1 (Prx1) in protecting apoptosis occurred in tubular epithelial cells of the rat and human kidney.
METHODS: Immunohistochemistry (IHC) staining was used to detect Prx1 expression in kidney derived from unilateral-ureteral obstruction (UUO) rats or patients with obstructive nephropathy. Modulation of …
Authors
Mei W; Peng Z; Lu M; Liu C; Deng Z; Xiao Y; Liu J; He Y; Yuan Q; Yuan X
Journal
Nephrology, Vol. 20, No. 11, pp. 832–842
Publisher
Wiley
Publication Date
November 2015
DOI
10.1111/nep.12515
ISSN
1320-5358
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedAnimalsApoptosisCell LineDisease Models, AnimalEnzyme ActivationEpithelial CellsFemaleFibrosisHumansHydrogen PeroxideKidneyKidney DiseasesMaleMiddle AgedOxidative StressPeroxiredoxinsPhosphorylationPyridonesRNA InterferenceRats, Sprague-DawleySignal TransductionTime FactorsTransfectionUreteral ObstructionYoung Adultp38 Mitogen-Activated Protein Kinases