Journal article
Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease
Abstract
Aims: Interventions to inhibit oxidative stress and apoptosis, important pathogenic contributors toward the progression of chronic kidney disease (CKD), are not well established. Here, we investigated the role of a transforming growth factor beta (TGFβ) superfamily neutralizing protein, follistatin (FST), in the regulation of apoptosis and oxidative stress in glomerular mesangial cells (MCs) and in the progression of CKD. Results: The …
Authors
Mehta N; Gava AL; Zhang D; Gao B; Krepinsky JC
Journal
Antioxidants and Redox Signaling, Vol. 31, No. 8, pp. 551–571
Publisher
Mary Ann Liebert
Publication Date
September 10, 2019
DOI
10.1089/ars.2018.7684
ISSN
1523-0864
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActivinsAnimalsAntioxidantsApoptosisCalciumEndoplasmic Reticulum StressFibrosisFollistatinGene ExpressionGene Expression RegulationKidney Function TestsLactonesMesangial CellsMiceNADPH Oxidase 4Oxidative StressRNA InterferenceRNA Processing, Post-TranscriptionalRNA, Small InterferingReactive Oxygen SpeciesRenal Insufficiency, ChronicSesquiterpenes