Journal article
Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules ofDrosophila melanogaster
Abstract
Insects excrete a wide variety of toxins via the Malpighian (renal) tubules. Previous studies have implicated three transporters in the secretion of the organic anion (OA) methotrexate (MTX) by the Drosophila Malpighian tubule: Drosophila multidrug resistance-associated protein (dMRP, CG6214), a multidrug efflux transporter (MET, CG30344), and an organic anion transporting polypeptide 58Dc (OATP58Dc, CG3380). RNA interference (RNAi) knockdown …
Authors
Chahine S; Campos A; O'Donnell MJ
Journal
Journal of Experimental Biology, Vol. 215, No. 15, pp. 2601–2610
Publisher
The Company of Biologists
Publication Date
August 1, 2012
DOI
10.1242/jeb.071100
ISSN
0022-0949
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP-Binding Cassette TransportersAllelesAnimalsDietDrosophila ProteinsDrosophila melanogasterGene Expression RegulationGene Knockdown TechniquesGenes, InsectIon TransportMalpighian TubulesMethotrexateMultidrug Resistance-Associated ProteinsMutagenesis, InsertionalOrganic Anion TransportersRNA InterferenceRNA, Messenger