Hydroxymethylglutaryl-CoA Reductase Inhibitors Concept

subject area of

• 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult  Journal Articles
• 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults  Journal Articles
• d-Dimer Testing to Select Patients With a First Unprovoked Venous Thromboembolism Who Can Stop Anticoagulant Therapy  Journal Articles
• A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial  Journal Articles
• A Model for Assessing the Cost-Effectiveness of Atorvastatin and Simvastatin in Achieving Canadian Low-Density Lipoprotein Cholesterol Targets  Journal Articles
• A Neuromuscular Approach to Statin-Related Myotoxicity  Journal Articles
• A Randomized Crossover Trial of Combination Pharmacologic Therapy in Children with Familial Hyperlipidemia  Journal Articles
• A comparison of pravastatin and gemfibrozil in the treatment of dyslipoproteinemia in patients with non-insulin-dependent diabetes mellitus  Journal Articles
• A new method for measurement of total plasma PCSK9: clinical applications  Journal Articles
• A randomized, placebo-controlled, double-blind trial to evaluate efficacy and safety of Shen-Yuan-Dan capsules, a traditional Chinese medicine, for treatment of peri-procedure myocardial injury following percutaneous coronary intervention  Journal Articles
• A review of the effects of statins in systemic sclerosis  Journal Articles
• A survey of physicians show a one-third reduction in harmful outcomes to be a clinically important difference for statin therapy  Journal Articles
• A treatment decision aid may increase patient trust in the diabetes specialist. The Statin Choice randomized trial  Journal Articles
• Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Design and Methods  Journal Articles
• Addition of Ezetimibe to statins for patients at high cardiovascular risk: Systematic review of patient‐important outcomes  Journal Articles
• Adjunctive Therapy in Community-Acquired Pneumonia  Journal Articles
• Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis  Journal Articles
• Age and sex differences, and changing trends, in the use of evidence-based therapies in acute coronary syndromes: perspectives from a multinational registry  Journal Articles
• Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial  Journal Articles
• An assessment by the Statin Muscle Safety Task Force: 2014 update  Journal Articles
• Anabolic Agents: A New Chapter in the Management of Osteoporosis  Journal Articles
• Antihypertensives and Statin Therapy for Primary Stroke Prevention: A Secondary Analysis of the HOPE-3 Trial  Journal Articles
• Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.  Journal Articles
• Are Patients with Inflammatory Bowel Disease at Increased Risk of Coronary Artery Disease?  Journal Articles
• Are the ACC/AHA Guidelines on the Treatment of Blood Cholesterol a Game Changer? A Perspective From the Canadian Cardiovascular Society Dyslipidemia Panel  Journal Articles
• Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia  Journal Articles
• Association Between Preoperative Statin Use and Acute Kidney Injury Biomarkers in Cardiac Surgical Procedures  Journal Articles
• Association between medication adherence and cardiovascular outcomes in patients with both diabetes and hypertension in primary care settings in Canada: A retrospective cohort study.  Journal Articles
• Association between pre-operative statin use and major cardiovascular complications among patients undergoing non-cardiac surgery: the VISION study  Journal Articles
• Association of Fenofibrate Therapy With Long-term Cardiovascular Risk in Statin-Treated Patients With Type 2 Diabetes  Journal Articles
• Association of Statin Therapy with Outcomes of Acute Coronary Syndromes: The GRACE Study  Journal Articles
• Association of Statins and Statin Discontinuation With Poor Outcome and Survival After Intracerebral Hemorrhage  Journal Articles
• Association of common variants in the human eyes shut ortholog (EYS) with statin‐induced myopathy: Evidence for additional functions of EYS  Journal Articles
• Association of statin therapy and the risk of atrial fibrillation in patients with a permanent pacemaker  Journal Articles
• Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study  Journal Articles
• Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase  Journal Articles
• Atorvastatin Restores Endothelial Function in Normocholesterolemic Smokers Independent of Changes in Low-Density Lipoprotein  Journal Articles
• Atorvastatin for high-risk statin-naïve patients undergoing noncardiac surgery: The Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose (LOAD) randomized trial  Journal Articles
• Author’s response  Journal Articles
• Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data  Journal Articles
• Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data.  Journal Articles
• Back to Back: All people over 75 years with a five-year CVD risk of ≥ 15% should be treated with statins unless specifically contraindicated: No  Journal Articles
• Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, Canada  Journal Articles
• Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient  Journal Articles
• Blood pressure and other determinants of new-onset atrial fibrillation in patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease studies  Journal Articles
• Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease  Journal Articles
• Building Your Peripheral Artery Disease Toolkit: Medical Management of Peripheral Artery Disease in 2022  Journal Articles
• C-reactive protein is a mediator of cardiovascular disease  Journal Articles
• Canadian Cardiovascular Society Guidelines for the Diagnosis and Management of Stable Ischemic Heart Disease  Journal Articles
• Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018  Journal Articles
• Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy  Journal Articles
• CardioDiabetes: Core Competencies for Cardiovascular Clinicians in a Rapidly Evolving Era of Type 2 Diabetes Management  Journal Articles
• Cardiovascular Risk Factors and In-hospital Mortality in Acute Coronary Syndromes: Insights From the Canadian Global Registry of Acute Coronary Events  Journal Articles
• Case selection for statins was similar in two Canadian provinces: BC and Ontario  Journal Articles
• Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease  Journal Articles
• Clinical Perspectives of Statin-Induced Rhabdomyolysis  Journal Articles
• Clinical Usefulness of Tissue Doppler Imaging in Patients with Mild to Moderate Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin Study  Journal Articles
• Clinical decisions. Management of stable coronary disease.  Journal Articles
• Clinical features related to statin‐associated muscle symptoms  Journal Articles
• Clinician's use of the Statin Choice decision aid in patients with diabetes: a videographic study nested in a randomized trial  Journal Articles
• Cochrane corner: early statin therapy in acute coronary syndromes—what is the clinical benefit?  Journal Articles
• Coenzyme A Reductase Inhibitors and Stroke  Journal Articles
• Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels  Journal Articles
• Colchicine for Secondary Prevention of Cardiovascular Disease  Journal Articles
• Combination Therapy to Prevent Cardiovascular Disease  Journal Articles
• Comparison of Risk Factor Reduction and Tolerability of a Full-Dose Polypill (With Potassium) Versus Low-Dose Polypill (Polycap) in Individuals at High Risk of Cardiovascular Diseases  Journal Articles
• Comparison of Utilization of Statin Therapy at Hospital Discharge and Six-Month Outcomes in Patients With an Acute Coronary Syndrome and Serum Low-Density Lipoprotein ≥100 mg/dl Versus <100 mg/dl  Journal Articles
• Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants  Journal Articles
• Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins  Journal Articles
• Concurrent Use of Statins in Patients Undergoing Curative Intent Treatment for Triple Negative Breast Cancer: A Systematic Review and Meta-Analysis  Journal Articles
• Concurrent use of statins and neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and meta-analysis  Journal Articles
• Cost-Effectiveness of Polygenic Risk Scores to Guide Statin Therapy for Cardiovascular Disease Prevention  Journal Articles
• Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): Protocol for a pragmatic, cluster-randomized controlled trial  Journal Articles
• Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016)  Journal Articles
• Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Working Group Consensus Update  Journal Articles
• Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Proceedings of a Canadian Working Group Consensus Conference  Journal Articles
• Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants1–3  Journal Articles
• Direct comparison of dietary portfolio vs statin on C-reactive protein  Journal Articles
• Discordance Between Physicians' Estimation of Patient Cardiovascular Risk and Use of Evidence-Based Medical Therapy  Journal Articles
• Does Googling lead to statin intolerance?  Journal Articles
• Does Statin Therapy Decrease the Risk for Bleeding in Patients Who Are Receiving Warfarin?  Journal Articles
• Does the Number of Pharmacies a Patient Frequents Affect Adherence to Statins?  Journal Articles
• Does the magnitude of lipid lowering with statin therapy indicate higher intracranial bleeding risk?  Journal Articles
• Drug Therapies in the Secondary Prevention of Cardiovascular Diseases:Successes, Shortcomings and Future Directions  Journal Articles
• Dyslipidemia in systemic lupus erythematosus: just another comorbidity?  Journal Articles
• Early Withdrawal of Statin Therapy in Patients With Non–ST-Segment Elevation Myocardial Infarction<subtitle>National Registry of Myocardial Infarction</subtitle>  Journal Articles
• Effect of Alirocumab on Mortality After Acute Coronary Syndromes  Journal Articles
• Effect of Different Antilipidemic Agents and Diets on Mortality  Journal Articles
• Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia  Journal Articles
• Effect of HMGcoA Reductase Inhibitors on Stroke  Journal Articles
• Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis  Journal Articles
• Effect of Statin Use Within the First 24 Hours of Admission for Acute Myocardial Infarction on Early Morbidity and Mortality††A complete list of participating hospitals is available from ClinTrials Research, 1100 Weston Parkway, Cary, North Carolina 27513.  Journal Articles
• Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis  Journal Articles
• Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials  Journal Articles
• Effect of statins on disease-related outcomes in patients with idiopathic pulmonary fibrosis  Journal Articles
• Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus  Journal Articles
• Effects of Early Treatment With Statins on Short-term Clinical Outcomes in Acute Coronary Syndromes  Journal Articles
• Effects of Ezetimibe Add-on to Statin Therapy on Adipokine Production in Patients With Metabolic Syndrome and Stable Vascular Disease  Journal Articles
• Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein  Journal Articles
• Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial  Journal Articles
• Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial&nbsp;  Journal Articles
• Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis  Journal Articles
• Effects of statins on stroke prevention in patients with and without coronary heart disease: A meta-analysis of randomized controlled trials  Journal Articles
• Efficacy and Safety of Statins for Secondary Stroke Prevention in Patients With Cerebral Microbleeds  Journal Articles
• Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance  Journal Articles
• Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials  Journal Articles
• Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins  Journal Articles
• Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials  Journal Articles
• Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials  Journal Articles
• Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials  Journal Articles
• Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis  Journal Articles
• Elevations in Creatine Kinase are Not Related to the Choice or Dose of Statins in Patients Taking Colchicine 0.5 mg Daily: Insights from the LoDoCo2 Trial  Journal Articles
• Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults  Journal Articles
• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Journal Articles
• Evolocumab in HIV-Infected Patients With Dyslipidemia  Journal Articles
• Exploring patient demographic and clinical characteristics associated with lipid-lowering pharmacotherapy use in primary care  Journal Articles
• Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes  Journal Articles
• Ezetimibe in high-risk, previously treated statin patients: a systematic review and network meta-analysis of lipid efficacy  Journal Articles
• Fixed-Dose Combination Therapy for the Prevention of Cardiovascular Diseases in CKD  Journal Articles
• Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance  Journal Articles
• Genetic risk factors associated with lipid‐lowering drug‐induced myopathies  Journal Articles
• HOPE­‑3, BP treatment, milestones in CV prevention. Dr. Salim Yusuf in an interview with Dr. Akbar Panju and Dr. Roman Jaeschke  Journal Articles
• Helping Patients With Type 2 Diabetes Mellitus Make Treatment Decisions  Conferences
• Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases  Journal Articles
• How clinically relevant is statin-induced diabetes?  Journal Articles
• How should the impact of different presentations of treatment effects on patient choice be evaluated? A pilot randomized trial  Journal Articles
• Hyperglycaemic disorders associated with PCSK9 inhibitors: a real-world, pharmacovigilance study  Journal Articles
• Identifying and Treating Young Patients at Risk for Cardiovascular Events  Journal Articles
• Immunomodulatory agents for the treatment of cachexia  Journal Articles
• Impact of Evidence‐Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study  Journal Articles
• Impact of Metabolic Syndrome on Progression of Aortic Stenosis  Journal Articles
• Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study  Journal Articles
• Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry  Journal Articles
• Impact of diabetes, angiotensin‐converting enzyme inhibitor or angiotensin II receptor blocker use, and statin use on presentation and outcomes in patients with giant cell arteritis  Conferences
• Impact of routine in-hospital assessment of low-density lipoprotein levels and standardized orders on statin therapy in patients undergoing percutaneous coronary interventions.  Journal Articles
• Implementation of the appointment-based model in community pharmacies: An analysis of refills and adherence  Journal Articles
• Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison  Journal Articles
• Indications for Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention in Chronic Stable Angina  Journal Articles
• Individual lifetime benefit from low-dose colchicine in patients with chronic coronary artery disease  Conferences
• Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia  Journal Articles
• Insulin Resistance and LVH Progression in Patients With Calcific Aortic Stenosis  Journal Articles
• Intensity of and Adherence to Lipid‐Lowering Therapy as Predictors of Major Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease  Journal Articles
• Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients  Journal Articles
• International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction  Journal Articles
• International Prevalence, Recognition, and Treatment of Cardiovascular Risk Factors in Outpatients With Atherothrombosis  Journal Articles
• Interpretation of the evidence for the efficacy and safety of statin therapy  Journal Articles
• Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial  Journal Articles
• Is aggressive lipid‐lowering therapy preferable to angioplasty in stable coronary artery disease?  Journal Articles
• Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy  Journal Articles
• Length of Initial Prescription at Hospital Discharge and Long-term Medication Adherence for Elderly Patients With Coronary Artery Disease: A Population-Level Study  Journal Articles
• Limitations of statin monotherapy for the treatment of dyslipidemia: a projection based on the Canadian lipid study – observational  Journal Articles
• Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline  Journal Articles
• Lipid control and stroke risk in atrial fibrillation patients treated with direct oral anticoagulants and statins.  Journal Articles
• Lipid lowering for primary prevention  Journal Articles
• Lipid-lowering therapies for cardiovascular disease prevention and management in primary care  Journal Articles
• Lipid-lowering treatment intensity, persistence, adherence and goal attainment in patients with coronary heart disease  Journal Articles
• Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis  Journal Articles
• Local statins used as an adjunct to nonsurgical periodontal treatment decrease residual pocket depth and increase clinical attachment level  Journal Articles
• Long-term Effects of Statins, Blood Pressure-Lowering, and Both on Erectile Function in Persons at Intermediate Risk for Cardiovascular Disease: A Substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) Randomized Controlled Trial  Journal Articles
• Long-term outcomes after acute myocardial infarction in countries with different socioeconomic environments: an international prospective cohort study  Journal Articles
• Lovastatin Sensitizes Lung Cancer Cells to Ionizing Radiation: Modulation of Molecular Pathways of Radioresistance and Tumor Suppression  Journal Articles
• Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients  Journal Articles
• Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease  Journal Articles
• MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience  Journal Articles
• Management of acute coronary syndromes in developing countries: ACute Coronary Events—a multinational Survey of current management Strategies  Journal Articles
• Medical Treatment of Peripheral Arterial Disease  Journal Articles
• Metabolic Myopathies Discovered During Investigations of Statin Myopathy  Journal Articles
• Missed opportunities for the secondary prevention of cardiovascular disease in Canada  Journal Articles
• Modulation of arterial reactivity using amlodipine and atorvastatin measured by ultrasound examination (MARGAUX)  Journal Articles
• Molecular clues into the pathogenesis of statin‐mediated muscle toxicity  Journal Articles
• Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo  Journal Articles
• Myocardial injury after noncardiac surgery  Journal Articles
• Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy  Journal Articles
• Nitrous Oxide and Serious Morbidity and Mortality in the POISE Trial  Journal Articles
• Optimal Medical Therapy, Lifestyle Intervention, and Secondary Prevention Strategies for Cardiovascular Event Reduction in Ischemic Heart Disease  Journal Articles
• Optimal management of familial hypercholesterolemia: treatment and management strategies.  Journal Articles
• Optimizing Cholesterol Treatment in Patients With Muscle Complaints  Journal Articles
• Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer  Journal Articles
• Overview of Therapeutic Approaches for Cholesterol Lowering and Attenuation of Thrombosis for Prevention of Atherothrombosis  Journal Articles
• PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations  Journal Articles
• PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis  Journal Articles
• PEER simplified lipid guideline 2023 update  Journal Articles
• Part 9: Acute Coronary Syndromes  Journal Articles
• Persistence and adherence to cholesterol lowering agents: Evidence from Régie de l'Assurance Maladie du Québec data  Journal Articles
• Polypill for Cardiovascular Disease Prevention—Reply  Journal Articles
• Polypill: the evidence and the promise  Journal Articles
• Pooled RCTs: Lowering LDL-C levels using statins reduces major vascular events in all age groups  Journal Articles
• Pour quels patients les nouveaux traitements hypolipémiants réduisent-ils les événements cardiovasculaires ?  Journal Articles
• Pre-Hospital Cardiac Arrest in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events  Journal Articles
• Preoperative Statin Use and Postoperative Acute Kidney Injury  Journal Articles
• Prevention of Cardiovascular Disease in Persons with Type 2 Diabetes Mellitus: Current Knowledge and Rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial  Journal Articles
• Pre‐ and post‐stroke oral antithrombotics and mortality in patients with ischaemic stroke  Journal Articles
• Primary Prevention With Statin Therapy in the Elderly  Journal Articles
• Primary Prevention of Cardiovascular Mortality and Events With Statin Treatments  Journal Articles
• Progressive muscle weakness: More there than meets the eye  Journal Articles
• Rapid increase in statins newly dispensed to Ontario seniors between 1994 and 2000.  Journal Articles
• Rationale and Design of the Statin Use in Intracerebral Hemorrhage Patients (SATURN) Trial  Journal Articles
• Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis  Journal Articles
• Reaching recommended lipid and blood pressure targets with amlodipine/atorvastatin combination in patients with coronary heart disease  Journal Articles
• Reasons for resistance to aspirin in cardiovascular disease.  Journal Articles
• Relationship between prior statin therapy and radiological features and clinical outcomes of intracerebral hemorrhage  Journal Articles
• Relative effects of LDL-C on ischemic stroke and coronary disease  Journal Articles
• Repurposing Two Old Friends to Fight Cancer: Caffeine and Statins  Journal Articles
• Results of a randomized controlled trial on statin use in dialysis patients had no influence on statin prescription  Journal Articles
• Risk Factors, Use of Preventive Drugs, and Cardiovascular Events in Diabetes Mellitus: The PURE Türkiye Cohort  Journal Articles
• Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4  Journal Articles
• Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence  Journal Articles
• Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering  Journal Articles
• Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials  Journal Articles
• STATIN DRUGS AND DIETARY ISOPRENOIDS AS ANTITHROMBOTIC AGENTS  Journal Articles
• Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study.  Journal Articles
• Sex Differences in the Recognition, Monitoring, and Management of CKD in Health Care: An Observational Cohort Study  Journal Articles
• Should Clinicians Deliver Decision Aids? Further Exploration of the Statin Choice Randomized Trial Results  Conferences
• Should we give aspirins and statins to the elderly?  Journal Articles
• Should we give aspirins and statins to the elderly?  Journal Articles
• Simvastatin monotherapy as a potential option for statin-associated muscle symptoms: a case report  Journal Articles
• State-of-the-Art-Review : Statins Induce Hypothrombotic States?  Journal Articles
• Statin Safety in Chinese: A Population-Based Study of Older Adults  Journal Articles
• Statin Therapy and Outcomes in Trials of Nintedanib in Idiopathic Pulmonary Fibrosis  Journal Articles
• Statin Therapy in Stroke Prevention: A Meta-analysis Involving 121,000 Patients  Journal Articles
• Statin Toxicity From Macrolide Antibiotic Coprescription  Journal Articles
• Statin Toxicity From Macrolide Antibiotic Coprescription  Journal Articles
• Statin Use Associates with a Lower Incidence of Acute Kidney Injury after Major Elective Surgery  Journal Articles
• Statin Use May Be Associated With a Lower Risk of Invasive Aspergillosis in Lung Transplant Recipients.  Journal Articles
• Statin Use and Survival in Patients with Metastatic Castration-resistant Prostate Cancer Treated with Abiraterone Acetate  Journal Articles
• Statin Use in Primary Prevention: A Simple Trial-Based Approach Compared With Guideline-Recommended Risk Algorithms for Selection of Eligible Patients  Journal Articles
• Statin administration activates system xC⁻ in skeletal muscle: a potential mechanism explaining statin-induced muscle pain  Journal Articles
• Statin myopathies: pathophysiologic and clinical perspectives.  Journal Articles
• Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses  Journal Articles
• Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials  Journal Articles
• Statin treatment and accrual of covert cerebral ischaemia on neuroimaging: a systematic review and meta‐analysis of randomized trials  Journal Articles
• Statin treatment and cerebral microbleeds: A systematic review and meta-analysis  Journal Articles
• Statin use and all-cause mortality in people living with HIV: a systematic review and meta-analysis  Journal Articles
• Statin-Associated Rhabdomyolysis: Is There a Dose-Response Relationship?  Journal Articles
• Statin-associated Autoimmune Myopathies: A Pathophysiologic Spectrum  Journal Articles
• Statin-associated neuromyotoxicity  Journal Articles
• Statin-associated neuromyotoxicity.  Journal Articles
• Statins Promote Interleukin-1β–Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol  Journal Articles
• Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR  Journal Articles
• Statins and Intracerebral Hemorrhage  Journal Articles
• Statins and Intracerebral Hemorrhage  Journal Articles
• Statins and Musculoskeletal Adverse Events  Journal Articles
• Statins and Musculoskeletal Adverse Events  Journal Articles
• Statins and Thrombin  Journal Articles
• Statins and renovascular disease in the elderly: a population-based cohort study  Journal Articles
• Statins for acute coronary syndrome  Journal Articles
• Statins for acute coronary syndrome  Journal Articles
• Statins for high cholesterol … and for low platelets?  Journal Articles
• Statins for people with kidney disease  Journal Articles
• Statins in the prevention of venous thromboembolism: A meta-analysis of observational studies  Journal Articles
• Statins: A new pharmacological agent for free flap surgery?  Journal Articles
• Statins: pleiotropic, but less than previously thought  Journal Articles
• Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies  Journal Articles
• Surgical biology for the clinician: vascular effects of immunosuppression.  Journal Articles
• Systematic Review on the Risk and Benefit of Different Cholesterol-Lowering Interventions  Journal Articles
• Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia  Journal Articles
• Targeting Cholesterol Crystal-Induced Inflammation for the Secondary Prevention of Cardiovascular Disease  Journal Articles
• Targeting the Unstable Plaque in Acute Coronary Syndromes  Journal Articles
• Temporal Patterns of Lipid Testing and Statin Therapy in Acute Coronary Syndrome Patients (from the Canadian GRACE Experience)  Journal Articles
• The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: A double-blind, placebo-controlled trial in patients with ESRD  Conferences
• The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd.  Journal Articles
• The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: A Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Clinical Practice Update  Journal Articles
• The International Polycap Study-3 (TIPS-3): Design, baseline characteristics and challenges in conduct  Journal Articles
• The New Dyslipidemia Guidelines: What Is the Debate?  Journal Articles
• The cost implication of primary prevention in the HOPE 3 trial  Journal Articles
• The cost implications of a polypill for primary prevention in the TIPS-3 trial  Journal Articles
• The effect of alternative summary statistics for communicating risk reduction on decisions about taking statins: a randomized trial  Journal Articles
• The effect of preoperative statins on postoperative mortality, renal, and neurological complications in patients undergoing cardiac surgeries: a retrospective cohort study  Journal Articles
• The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials  Journal Articles
• The effects of preoperative statins on the incidence of postoperative acute kidney injury in patients undergoing cardiac surgeries.  Journal Articles
• The effects of quinapril and atorvastatin on artery structure and function in adult spontaneously hypertensive rats  Journal Articles
• The impact of oral hypoglycemics and statins on outcomes in myelodysplastic syndromes  Journal Articles
• The impact of statins on melanoma survival: a systematic review and meta-analysis.  Journal Articles
• The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations  Journal Articles
• The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study  Journal Articles
• The number needed to treat (NNT) can be adjusted for bias when the outcome is measured with error  Journal Articles
• The polypill: from concept and evidence to implementation  Journal Articles
• There seems to be a higher proportion of patients with apical periodontitis who heal among those who consume statins regularly than among those who do not  Journal Articles
• Treatment with atorvastatin ameliorates hepatic very[ndash ]low-density lipoprotein overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster: Evidence that reduced hypertriglyceridemia is accompanied by improved hepatic insulin sensitivity  Journal Articles
• Updated evidence on early statin therapy for acute coronary syndromes: Meta-analysis of 18 randomized trials involving over 14,000 patients  Journal Articles
• Use of Combination Evidence-Based Medical Therapy Prior to Acute Myocardial Infarction (from the National Registry of Myocardial Infarction-4)  Journal Articles
• Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases  Journal Articles
• Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey  Journal Articles
• Varicose Remodeling of Veins Is Suppressed by 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Inhibitors  Journal Articles
• Vascular viewpoint  Journal Articles
• Who Should Receive HMG CoA Reductase Inhibitors?  Journal Articles
• Why do people not take life-saving medications? The case of statins  Journal Articles
• [A patient with the homozygote form of familial hypercholesterolemia].  Journal Articles