Journal article
Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
Abstract
OBJECTIVES: The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular events in patients with clinically stable coronary disease.
BACKGROUND: The presence of activated neutrophils in culprit atherosclerotic plaques of patients with unstable coronary disease raises the possibility that inhibition of neutrophil function with colchicine may reduce the risk of plaque instability and thereby …
Authors
Nidorf SM; Eikelboom JW; Budgeon CA; Thompson PL
Journal
Journal of the American College of Cardiology, Vol. 61, No. 4, pp. 404–410
Publisher
Elsevier
Publication Date
January 2013
DOI
10.1016/j.jacc.2012.10.027
ISSN
0735-1097
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute Coronary SyndromeAgedBrain InfarctionCanadaColchicineCoronary DiseaseDrug Therapy, CombinationEndpoint DeterminationFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceIntestinal DiseasesMaleOut-of-Hospital Cardiac ArrestPlaque, AtheroscleroticProportional Hazards ModelsRisk AssessmentSecondary PreventionTreatment OutcomeTubulin ModulatorsWithholding Treatment