Journal article
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
Abstract
BACKGROUND: We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for cardiovascular disease.
METHODS: We randomly assigned 5518 patients with type 2 diabetes who were being treated with open-label simvastatin to receive either masked fenofibrate or placebo. The primary outcome …
Authors
Ginsberg HN; Elam MB; Lovato LC; Crouse JR; Leiter LA; Linz P; Friedewald WT; Buse JB; Gerstein HC; Probstfield J
Journal
The New England Journal of Medicine, Vol. 362, No. 17, pp. 1563–1574
Publisher
Massachusetts Medical Society
Publication Date
April 29, 2010
DOI
10.1056/nejmoa1001282
ISSN
0028-4793
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedCardiovascular DiseasesCholesterolDiabetes Mellitus, Type 2Drug Therapy, CombinationFemaleFenofibrateFollow-Up StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionProportional Hazards ModelsSex FactorsSimvastatinStrokeTreatment FailureTriglycerides