Statin-Associated Rhabdomyolysis: Is There a Dose-Response Relationship?

BACKGROUND: Statins have a well-established role in prevention of vascular events but are associated with muscle-related adverse events. The dose relationship with these adverse events is unclear. We present an original analysis of Canadian and US case reports of statin-associated rhabdomyolysis with a focus on dose response. A typical clinical case is also summarized. METHODS: All cases of statin-associated rhabdomyolysis reported to Health …