Journal article
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Abstract
BACKGROUND: Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin therapy.
METHODS: Randomised trials of …
Authors
Reith C; Baigent C; Blackwell L; Emberson J; Spata E; Davies K; Halls H; Holland L; Wilson K; Armitage J
Journal
The Lancet, Vol. 400, No. 10355, pp. 832–845
Publisher
Elsevier
Publication Date
September 2022
DOI
10.1016/s0140-6736(22)01545-8
ISSN
0140-6736