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The impact of statins on physical activity and...
Journal article

The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations

Abstract

PurposeStatins are among the most widely prescribed medications worldwide. Considered the ‘gold-standard’ treatment for cardiovascular disease (CVD), statins inhibit HMG-CoA reductase to ultimately reduce serum LDL-cholesterol levels. Unfortunately, the main adverse event of statin use is the development of muscle-associated problems, referred to as SAMS (statin-associated muscle symptoms). While regular moderate physical activity also …

Authors

Schweitzer AM; Gingrich MA; Hawke TJ; Rebalka IA

Journal

European Journal of Applied Physiology, Vol. 120, No. 6, pp. 1205–1225

Publisher

Springer Nature

Publication Date

June 2020

DOI

10.1007/s00421-020-04360-2

ISSN

1439-6319