Journal article
The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations
Abstract
PurposeStatins are among the most widely prescribed medications worldwide. Considered the ‘gold-standard’ treatment for cardiovascular disease (CVD), statins inhibit HMG-CoA reductase to ultimately reduce serum LDL-cholesterol levels. Unfortunately, the main adverse event of statin use is the development of muscle-associated problems, referred to as SAMS (statin-associated muscle symptoms). While regular moderate physical activity also …
Authors
Schweitzer AM; Gingrich MA; Hawke TJ; Rebalka IA
Journal
European Journal of Applied Physiology, Vol. 120, No. 6, pp. 1205–1225
Publisher
Springer Nature
Publication Date
June 2020
DOI
10.1007/s00421-020-04360-2
ISSN
1439-6319