Factor Xa Concept

subject area of

• 4 Clinical potential of low molecular weight heparins  Journal Articles
• A Control Switch for Prothrombinase  Journal Articles
• A Historical Perspective on the Reversal of Anticoagulants  Journal Articles
• A PoTENtial Antidote  Journal Articles
• A hybrid automated event adjudication system for clinical trials  Journal Articles
• A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers  Journal Articles
• A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer  Journal Articles
• A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin  Journal Articles
• Accuracy of a Rapid Diagnostic Test for the Presence of Direct Oral Factor Xa or Thrombin Inhibitors in Urine—A Multicenter Trial  Journal Articles
• Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and d-Phe-Pro-Arg-Ch2Cl  Journal Articles
• Activation of factor X and prothrombin in antithrombin-III depleted plasma: The effects of heparin  Journal Articles
• Age-related differences in heparin response  Journal Articles
• An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice  Conferences
• An overview of clinical trials of low molecular weight heparin fractions.  Journal Articles
• An overview of the mechanism of action of antithrombin and its inherited deficiency states  Journal Articles
• Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors  Journal Articles
• Andexanet Alfa for Bleeding with Factor Xa Inhibitors  Journal Articles
• Andexanet Alfa for Specific Anticoagulation Reversal in Patients with Acute Bleeding during Treatment with Edoxaban  Journal Articles
• Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity  Journal Articles
• Andexanet alfa for reversal of factor Xa inhibitors: a critical review of the evidence  Journal Articles
• Andexanet alfa for the treatment of hemorrhage  Journal Articles
• Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis  Journal Articles
• Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa  Journal Articles
• Bleeding Complications and Management on anticoagulant therapy  Journal Articles
• Brief Communication: Preoperative Anticoagulant Activity after Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin  Journal Articles
• Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity  Journal Articles
• Chemical–Physical Characterization of Polyurethane Catheters Modified with a Novel Antithrombin-Heparin Covalent Complex  Journal Articles
• Clinical implications of reversal agents for direct oral anticoagulants  Journal Articles
• Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - A direct and selective antagonist  Journal Articles
• Comparison of the Non-Specific Binding of Unfractionated Heparin and Low Molecular Weight Heparin (Enoxaparin) to Plasma Proteins  Journal Articles
• Covalent antithrombin–heparin complexes  Journal Articles
• Covalently linking heparin to antithrombin enhances prothrombinase inhibition on activated platelets  Journal Articles
• Dabigatran: ready for prime time?  Journal Articles
• Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation  Journal Articles
• Duration of anticoagulant therapy for venous thromboembolism  Journal Articles
• Effects of Dermatan Sulfate and Heparin on Inhibition of Thrombus Growth in Vivo  Journal Articles
• Effects of Sulfated Polysaccharides on Inhibition of Thrombus Formation initiated by Different Stimuli  Journal Articles
• Effects of heparin fractions of different affinities to antithrombin III and thrombin on the inactivation of thrombin and factor Xa by antithrombin III  Journal Articles
• Enoxaparin Use in the Neonatal Intensive Care Unit: Experience Over 8 Years  Journal Articles
• Enoxaparin, a low molecular weight heparin, inhibits platelet-dependent prothrombinase assembly and activity by factor-Xa neutralization.  Journal Articles
• Evidence-Based Minireview: Mortality and thrombosis in patients receiving prothrombin complex concentrates or andexanet alfa for the management of direct oral factor Xa inhibitor–associated major bleeding  Journal Articles
• Factor Xa or thrombin: Is thrombin a better target?  Conferences
• Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors  Journal Articles
• Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors  Journal Articles
• Further Studies on the Mechanisms for the Antithrombotic Effects of Sulfated Polysaccharides in Rabbits  Journal Articles
• Glycosaminoglycans Bind Factor Xa in a Ca²⁺-Dependent Fashion and Modulate Its Catalytic Activity  Journal Articles
• Hematoma Expansion and Clinical Outcomes in Patients With Factor-Xa Inhibitor–Related Atraumatic Intracerebral Hemorrhage Treated Within the ANNEXA-4 Trial Versus Real-World Usual Care  Journal Articles
• Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways.  Journal Articles
• Heparin Binding to Plasma Proteins, an Important Mechanism for Heparin Resistance  Journal Articles
• Heparin Cofactor II and Other Endogenous Factors in the Mediation of the Antithrombotic and Anticoagulant Effects of Heparin and Dermatan Sulfate  Journal Articles
• Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma  Journal Articles
• Heparin and low molecular weight heparins as scaffolds for assembling antithrombin and serine proteases  Journal Articles
• Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma  Journal Articles
• Hirudin causes more bleeding than heparin in a rabbit ear bleeding model  Journal Articles
• How can we reverse bleeding in patients on direct oral anticoagulants?  Journal Articles
• How to use unfractionated heparin to treat neonatal thrombosis in clinical practice  Journal Articles
• Hypersulfated Low Molecular Weight Heparin with Reduced Affinity for Antithrombin Acts as an Anticoagulant by Inhibiting Intrinsic Tenase and Prothrombinase  Journal Articles
• INVIVO EFFECTS OF LOW-MOLECULAR-WEIGHT HEPARINS ON EXPERIMENTAL THROMBOSIS AND BLEEDING  Journal Articles
• Immobilization of an antithrombin–heparin complex on gold: Anticoagulant properties and platelet interactions  Journal Articles
• In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity  Journal Articles
• In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding  Journal Articles
• Incorporation of Factor Va into Prothrombinase Is Required for Coordinated Cleavage of Prothrombin by Factor Xa  Journal Articles
• Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate  Journal Articles
• Inhibition of Fibrin-Bound Thrombin by a Covalent Antithrombin-Heparin Complex  Journal Articles
• Inhibition of factor X, factor V and prothrombin activation by the bis(lactobionic acid amide) LW10082  Journal Articles
• Inhibition of the prothrombinase complex on red blood cells by heparin and covalent antithrombin-heparin complex  Journal Articles
• Interlaboratory variation in heparin monitoring: Lessons from the Quality Management Program of Ontario coagulation surveys  Journal Articles
• Letter to the editor  Journal Articles
• Linking Endogenous Factor Xa Activity, a Biologically Relevant Pharmacodynamic Marker, to Edoxaban Plasma Concentrations and Clinical Outcomes in the ENGAGE AF-TIMI 48 Trial  Journal Articles
• Measurement of factor Xa‐antithrombin III in plasma: relationship to prothrombin activation in vivo  Journal Articles
• Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex  Journal Articles
• Mechanisms responsible for the failure of protamine 
to inactivate low‐molecular‐weight heparin  Journal Articles
• Meta-Analysis: Low-Molecular-Weight Heparin and Bleeding in Patients with Severe Renal Insufficiency  Journal Articles
• Monitoring and reversal of direct oral anticoagulants  Journal Articles
• Monitoring the anticoagulant effect after a massive rivaroxaban overdose  Journal Articles
• Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation  Journal Articles
• NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank  Journal Articles
• Neutralization of Enoxaparine-lnduced Bleeding by Protamine Sulfate  Journal Articles
• New Antithrombotic Drugs: Potential for Use in Oncology  Journal Articles
• Novel oral anticoagulants and reversal agents: Considerations for clinical development  Journal Articles
• Oral Anticoagulant Therapy  Journal Articles
• Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement  Journal Articles
• Oral, Direct Factor Xa Inhibitors in Development for the Prevention and Treatment of Thromboembolic Diseases  Journal Articles
• PRE‐OPERATIVE FACTOR Xa–TFPI AND POST‐OPERATIVE VENOUS THROMBOSIS  Journal Articles
• PRODIGE: a randomized placebo‐controlled trial of dalteparin low‐molecular‐weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma  Journal Articles
• Protein adsorption on polyurethane catheters modified with a novel antithrombin‐heparin covalent complex  Journal Articles
• Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation  Journal Articles
• Rationale Behind the Development of Low Molecular Weight Heparin Derivatives  Journal Articles
• Recent Advances in Antidotes for Direct Oral Anticoagulants: Their Arrival Is Imminent  Journal Articles
• Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins  Journal Articles
• Restart of Anticoagulant Therapy and Risk of Thrombosis, Rebleeding, and Death after Factor Xa Inhibitor Reversal in Major Bleeding Patients  Journal Articles
• Reversal agents for non-vitamin K antagonist oral anticoagulants  Journal Articles
• Reversal of Direct Oral Anticoagulants: Current Status and Future Directions  Journal Articles
• Reversal of direct oral anticoagulants: Guidance from the Anticoagulation Forum  Journal Articles
• Reversal of direct oral anticoagulants: a practical approach  Journal Articles
• Rivaroxaban for treatment of suspected or confirmed heparin‐induced thrombocytopenia study  Journal Articles
• Serum-induced platelet procoagulant activity: An assay for the characterization of prothrombotic disorders  Journal Articles
• Site‐directed mutagenesis of the P2 residue of human antithrombin  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The Relationship of Antiphospholipid Antibodies to Thromboembolic Disease in Systemic Lupus Erythematosus: A Cross-Sectional Study  Journal Articles
• The fraction of recombinant factor VIII:Ag unable to bind von Willebrand factor has no FVIII coagulant activity: studies in vitro  Journal Articles
• The haemorrhagic and antithrombotic effects of dermatan sulphate  Journal Articles
• The haemorrhagic and antithrombotic effects of dermatan sulphate.  Journal Articles
• The importance of thrombin inhibition for the expression of the anticoagulant activities of heparin, dermatan sulphate, low molecular weight heparin and pentosan polysulphate  Journal Articles
• The inhibition of the anticoagulant activity of heparin by platelets, brain phospholipids, and tissue factor  Journal Articles
• The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin  Journal Articles
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase  Journal Articles
• The low molecular weight heparin Enoxaparin inhibits the consumption of factor VII and prothrombin activation in vivo associated with elective knee replacement surgery  Journal Articles
• The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin  Journal Articles
• Thrombolysis by chemically modified coagulation factor Xa  Journal Articles
• Thrombosis in inherited factor VII deficiency  Journal Articles
• Treatment of Proximal Deep Vein Thrombosis With a Novel Synthetic Compound (SR90107A/ORG31540) With Pure Anti–Factor Xa Activity  Journal Articles
• Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa  Journal Articles
• Utility of aPTT in monitoring unfractionated heparin in children  Journal Articles
• Very severe thrombocytopenia and fragmentation hemolysis mimicking thrombotic thrombocytopenic purpura associated with a giant intracardiac vegetation infected with Staphylococcus epidermidis: Role of monocyte procoagulant activity induced by bacterial supernatant  Journal Articles
• Volutrauma activates the clotting cascade in the newborn but not adult rat  Journal Articles
• When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH  Journal Articles
• Zn2+ Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen  Journal Articles