Journal article
Chemical–Physical Characterization of Polyurethane Catheters Modified with a Novel Antithrombin-Heparin Covalent Complex
Abstract
Detailed structural studies were made of polyurethane catheter surfaces modified with a covalent antithrombin-heparin (ATH) complex that has superior anticoagulant activity compared to unfractionated heparin. ATH was grafted onto polyurethane catheters by surface film preparation involving a three-step process: (1) activation of ATH through functionalized poly(ethylene glycol) (PEG), (2) base-coating treatment of the polyurethane surface and …
Authors
Du YJ; Berry LR; Chan AKC
Journal
Journal of Biomaterials Science Polymer Edition, Vol. 22, No. 17, pp. 2277–2294
Publisher
Taylor & Francis
Publication Date
January 2011
DOI
10.1163/092050610x538227
ISSN
0920-5063
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnticoagulantsBiocompatible MaterialsCalorimetry, Differential ScanningCathetersElectrophoresis, Polyacrylamide GelEquipment DesignFactor XaFibrinolytic AgentsFree RadicalsHeparinMaterials TestingPhotoelectron SpectroscopyPolyethylene GlycolsPolyhydroxyethyl MethacrylatePolymerizationPolyurethanesSurface Properties