Journal article
Enoxaparin, a Low Molecular Weight Heparin, Inhibits Platelet-Dependent Prothrombinase Assembly and Activity by Factor-Xa Neutralization
Abstract
Background: The available evidence suggests strongly that intravascular thrombosis is mediated predominantly by tissue-factor and its activation of factor X, which in the presence of factor Va, calcium, and phospholipid (prothrombinase complex) effectively converts prothrombin to thrombin. In vitro experiments have shown that low molecular weight heparins (LMWHs) have greater anti-Xa activity than unfractionated heparin; however, it remains …
Authors
Spencer FA; Ball SP; Zhang Q; Liu L; Benoit S; Becker RC
Journal
Journal of Thrombosis and Thrombolysis, Vol. 9, No. 3, pp. 223–228
Publisher
Springer Nature
Publication Date
April 2000
DOI
10.1023/a:1018710526772
ISSN
0929-5305