Proto-Oncogene Proteins
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Escherichia coliShiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family Academic Article
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A Conserved African Swine Fever Virus IκB Homolog, 5EL, Is Nonessential for Growthin Vitroand Virulence in Domestic Swine Academic Article
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A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer Academic Article
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A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer Academic Article
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A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes Academic Article
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A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model Academic Article
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Akt Is Activated in Response to an Apoptotic Signal Academic Article
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Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells Academic Article
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Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties Academic Article
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Apoptosis and other effects of radiation in normal human urothelial cells Academic Article
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Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway Academic Article
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Assembly of Bcl-2 into microsomal and outer mitochondrial membranes Academic Article
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Association Between Preoperative Statin Use and Acute Kidney Injury Biomarkers in Cardiac Surgical Procedures Academic Article
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Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study Academic Article
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BCL-2: the pendulum of the cell fate. Academic Article
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BH3-only proteins: Orchestrators of apoptosis Academic Article
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Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death Academic Article
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Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator Academic Article
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Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. Academic Article
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Biomarkers Predict Progression of Acute Kidney Injury after Cardiac Surgery Academic Article
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Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery Academic Article
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Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells Academic Article
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Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression Academic Article
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Brain region-specific and time-dependent decreases of G?i2 in amygdala-kindled rats Academic Article
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CANTRK Academic Article
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CD34-positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform Academic Article
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Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer Academic Article
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Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at thetrans-Golgi Network To Promote Virus Replication Academic Article
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Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model Academic Article
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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas Academic Article
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Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma Academic Article
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Crizotinib Inhibition of ROS1-Positive Tumours in Advanced Non-Small-Cell Lung Cancer: A Canadian Perspective Academic Article
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Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 CompositecisElements Academic Article
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D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour Academic Article
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Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial Academic Article
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Detection of an Involvement of the Human Mismatch Repair Genes
hMLH1
and
hMSH2
in Nucleotide Excision Repair Is Dependent on UVC Fluence to Cells Academic Article
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Differences in Functional Consequences and Signal Transduction Induced by IL-3, IL-5, and Nerve Growth Factor in Human Basophils Academic Article
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Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells Academic Article
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Differential response of primitive human CD34− and CD34+ hematopoietic cells to the Notch ligand Jagged-1 Academic Article
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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax Academic Article
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Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division Academic Article
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ETS Proteins and MMPs: Partners in Invasion and Metastasis Academic Article
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Effect of docetaxel (taxotere) on expression of radiation-induced lethal mutations in human cell lines Academic Article
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Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells Academic Article
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Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event Academic Article
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Exon-skipping in BCR/ABL is induced by ABL exon 2 Academic Article
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Expression of Ets-related Transcription Factors and Matrix Metalloproteinase Genes in Human Breast Cancer Cells Academic Article
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Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens Academic Article
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Expression of apoptosis-related proteins in thyroid tumors and thyroid carcinoma cell lines Academic Article
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Expression of c-erb B-2 oncogene product in persistent gestational trophoblastic disease Academic Article
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Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens Conference Paper
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Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis Academic Article
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Extending knowledge on inherited platelet disorders associated with thrombocytopenia Academic Article
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Gene targeting in mouse embryonic stem cells with an adenoviral vector Academic Article
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Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 Academic Article
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Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors Academic Article
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Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis Academic Article
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HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation Academic Article
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HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Academic Article
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Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells Academic Article
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Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition Academic Article
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Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis Academic Article
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Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin. Academic Article
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Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells Academic Article
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Induction of Mdm2 and enhancement of cell survival by bFGF Academic Article
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Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells Academic Article
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Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis Academic Article
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Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET Academic Article
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LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML Academic Article
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Lithium and hydrocortisone interactions on cell growth and gene expression in human promyelocytic leukemia (HL60) Academic Article
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Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Academic Article
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Macrophage Function and Its Impact on Atherosclerotic Lesion Composition, Progression, and Stability Academic Article
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Manganese Superoxide Dismutase Levels Are Elevated in a Proportion of Amyotrophic Lateral Sclerosis Patient Cell Lines Academic Article
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Mas receptors in modulating relaxation induced by perivascular adipose tissue Academic Article
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Menin Is a Regulator of the Stress Response in Drosophila melanogaster Academic Article
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Menin: The Protein Behind the MEN1 Syndrome Academic Article
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Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host Academic Article
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Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts Academic Article
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Modulation of vein function by perivascular adipose tissue Academic Article
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Multiple Signaling Pathways Control the Activation of the CEF-4/9E3 Cytokine Gene by pp60v- Academic Article
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Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria Academic Article
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Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor Academic Article
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Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter Academic Article
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Origin and Differentiation of Supernumerary Midline Glia inDrosophilaEmbryos Deficient for Apoptosis Academic Article
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PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2 Academic Article
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PTEN inhibits BMI1 function independently of its phosphatase activity Academic Article
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Pathway Pathology Academic Article
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Patterning an Epidermal Field:DrosophilaLozenge, a Member of the AML-1/Runt Family of Transcription Factors, Specifies Olfactory Sense Organ Type in a Dose-Dependent Manner Academic Article
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Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells Academic Article
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Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery Academic Article
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Permissiveness of Human Cancer Cells to Oncolytic Bovine Herpesvirus 1 Is Mediated in Part by KRAS Activity Academic Article
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Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis Academic Article
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Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children Academic Article
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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance Academic Article
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Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light Academic Article
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Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery Academic Article
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Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice Academic Article
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Polo-like kinases in AML Academic Article
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Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery Academic Article
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Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery Academic Article
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Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2 Academic Article
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Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis Academic Article
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Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 Academic Article
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Role of Ets transcription factors in mammary gland development and oncogenesis. Academic Article
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Role of the transcription factor Ets-1 in cisplatin resistance Academic Article
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Selective involvement of the PI3K/PKB/bad pathway in retinal cell death Academic Article
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Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse Academic Article
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Small molecules reveal an alternative mechanism of Bax activation Academic Article
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Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells Academic Article
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Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells Academic Article
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Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf Academic Article
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TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation Academic Article
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Testing New Biomarkers for Acute Kidney Injury: Association, Prediction, and Intervention Academic Article
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The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO Academic Article
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The HER-2/neu oncogene in breast cancer: so what is new? Academic Article
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The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase Academic Article
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The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours Academic Article
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The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Academic Article
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The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes Academic Article
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The lnterleukin-5/Receptor Interaction Activates Lyn and Jak2 Tyrosine Kinases and Propagates Signals via the Ras-Raf-1-MAP Kinase and the Jak-STAT Pathways in Eosinophils Conference Paper
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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults Academic Article
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The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer Academic Article
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Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO Academic Article
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Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis Academic Article
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Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine. Academic Article
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W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity Academic Article
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Williams–Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO Academic Article
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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cellsinvivo Academic Article
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bcl-2 protein expression in melanocytic neoplasms of the skin. Academic Article
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c-Jun Homodimers Can Function as a Context-Specific Coactivator Academic Article
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miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis Academic Article
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miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours Academic Article
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p73 Is Regulated by Phosphorylation at the G2/M Transition Academic Article