Proto-Oncogene Proteins Concept

subject area of

• Escherichia coliShiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family  Journal Articles
• A Conserved African Swine Fever Virus IκB Homolog, 5EL, Is Nonessential for Growthin Vitroand Virulence in Domestic Swine  Journal Articles
• A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer  Journal Articles
• A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer  Journal Articles
• A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes  Journal Articles
• A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells  Journal Articles
• Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties  Journal Articles
• Apoptosis and other effects of radiation in normal human urothelial cells  Journal Articles
• Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway  Journal Articles
• Assembly of Bcl-2 into microsomal and outer mitochondrial membranes  Journal Articles
• Association Between Preoperative Statin Use and Acute Kidney Injury Biomarkers in Cardiac Surgical Procedures  Journal Articles
• Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study  Journal Articles
• BCL-2: the pendulum of the cell fate.  Journal Articles
• BH3-only proteins: Orchestrators of apoptosis  Journal Articles
• Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death  Journal Articles
• Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator  Journal Articles
• Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.  Journal Articles
• Biomarkers Predict Progression of Acute Kidney Injury after Cardiac Surgery  Journal Articles
• Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery  Journal Articles
• Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells  Journal Articles
• Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression  Journal Articles
• Brain region-specific and time-dependent decreases of G?i2 in amygdala-kindled rats  Journal Articles
• CANTRK  Journal Articles
• CD34‐positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform  Journal Articles
• Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer  Journal Articles
• Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at thetrans-Golgi Network To Promote Virus Replication  Journal Articles
• Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion  Journal Articles
• Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model  Journal Articles
• Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas  Journal Articles
• Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma  Journal Articles
• Crizotinib Inhibition of ROS1-Positive Tumours in Advanced Non-Small-Cell Lung Cancer: A Canadian Perspective  Journal Articles
• Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 CompositecisElements  Journal Articles
• D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour  Journal Articles
• Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial  Journal Articles
• Detection of an Involvement of the Human Mismatch Repair Genes hMLH1 and hMSH2 in Nucleotide Excision Repair Is Dependent on UVC Fluence to Cells  Journal Articles
• Differences in Functional Consequences and Signal Transduction Induced by IL-3, IL-5, and Nerve Growth Factor in Human Basophils  Journal Articles
• Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells  Journal Articles
• Differential response of primitive human CD34− and CD34+ hematopoietic cells to the Notch ligand Jagged-1  Journal Articles
• Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax  Journal Articles
• Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division  Journal Articles
• ETS Proteins and MMPs: Partners in Invasion and Metastasis  Journal Articles
• Effect of docetaxel (taxotere) on expression of radiation-induced lethal mutations in human cell lines  Journal Articles
• Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells  Journal Articles
• Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms  Journal Articles
• Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event  Journal Articles
• Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia.  Journal Articles
• Exon-skipping in BCR/ABL is induced by ABL exon 2  Journal Articles
• Expression of Ets-related Transcription Factors and Matrix Metalloproteinase Genes in Human Breast Cancer Cells  Journal Articles
• Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens  Journal Articles
• Expression of apoptosis-related proteins in thyroid tumors and thyroid carcinoma cell lines  Journal Articles
• Expression of c-erb B-2 oncogene product in persistent gestational trophoblastic disease  Journal Articles
• Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens  Conferences
• Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis  Journal Articles
• Extending knowledge on inherited platelet disorders associated with thrombocytopenia  Journal Articles
• Gene targeting in mouse embryonic stem cells with an adenoviral vector  Journal Articles
• Gene transcription of fgl2 in endothelial cells is controlled by Ets‐1 and Oct‐1 and requires the presence of both Sp1 and Sp3  Journal Articles
• Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors  Journal Articles
• Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis  Journal Articles
• HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation  Journal Articles
• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition  Journal Articles
• Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis  Journal Articles
• Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.  Journal Articles
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Journal Articles
• Induction of Mdm2 and enhancement of cell survival by bFGF  Journal Articles
• Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells  Journal Articles
• Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis  Journal Articles
• Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET  Journal Articles
• LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML  Journal Articles
• Lithium and hydrocortisone interactions on cell growth and gene expression in human promyelocytic leukemia (HL60)  Journal Articles
• Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)  Journal Articles
• Macrophage Function and Its Impact on Atherosclerotic Lesion Composition, Progression, and Stability  Journal Articles
• Manganese Superoxide Dismutase Levels Are Elevated in a Proportion of Amyotrophic Lateral Sclerosis Patient Cell Lines  Journal Articles
• Mas receptors in modulating relaxation induced by perivascular adipose tissue  Journal Articles
• Menin Is a Regulator of the Stress Response in Drosophila melanogaster  Journal Articles
• Menin: The Protein Behind the MEN1 Syndrome  Journal Articles
• Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host  Journal Articles
• Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts  Journal Articles
• Modulation of vein function by perivascular adipose tissue  Journal Articles
• Multiple Signaling Pathways Control the Activation of the CEF-4/9E3 Cytokine Gene by pp60v-  Journal Articles
• Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria  Journal Articles
• Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor  Journal Articles
• Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function  Journal Articles
• Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter  Journal Articles
• Origin and Differentiation of Supernumerary Midline Glia inDrosophilaEmbryos Deficient for Apoptosis  Journal Articles
• PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2  Journal Articles
• PTEN inhibits BMI1 function independently of its phosphatase activity  Journal Articles
• Pathway Pathology  Journal Articles
• Patterning an Epidermal Field:DrosophilaLozenge, a Member of the AML-1/Runt Family of Transcription Factors, Specifies Olfactory Sense Organ Type in a Dose-Dependent Manner  Journal Articles
• Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells  Journal Articles
• Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery  Journal Articles
• Permissiveness of Human Cancer Cells to Oncolytic Bovine Herpesvirus 1 Is Mediated in Part by KRAS Activity  Journal Articles
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis  Journal Articles
• Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children  Journal Articles
• Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance  Journal Articles
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross‐Resistance to UVA but not UVC Light  Journal Articles
• Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery  Journal Articles
• Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice  Journal Articles
• Polo-like kinases in AML  Journal Articles
• Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery  Journal Articles
• Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery  Journal Articles
• Prospective Cost-Effectiveness Analysis of Cetuximab in Metastatic Colorectal Cancer: Evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 Trial  Journal Articles
• Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2  Journal Articles
• Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis  Journal Articles
• Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21  Journal Articles
• Role of Ets transcription factors in mammary gland development and oncogenesis.  Journal Articles
• Role of the transcription factor Ets-1 in cisplatin resistance  Journal Articles
• Selective involvement of the PI3K/PKB/bad pathway in retinal cell death  Journal Articles
• Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse  Journal Articles
• Small molecules reveal an alternative mechanism of Bax activation  Journal Articles
• Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells  Journal Articles
• Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells  Journal Articles
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Journal Articles
• TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation  Journal Articles
• Testing New Biomarkers for Acute Kidney Injury: Association, Prediction, and Intervention  Journal Articles
• The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO  Journal Articles
• The HER-2/neu oncogene in breast cancer: so what is new?  Journal Articles
• The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase  Journal Articles
• The Wnt pathway, epithelial–stromal interactions, and malignant progression in phyllodes tumours  Journal Articles
• The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults  Journal Articles
• The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer  Journal Articles
• Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO  Journal Articles
• Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis  Journal Articles
• Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine.  Journal Articles
• W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity  Journal Articles
• Williams–Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO  Journal Articles
• Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cellsinvivo  Journal Articles
• c-Jun Homodimers Can Function as a Context-Specific Coactivator  Journal Articles
• miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis  Journal Articles
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Journal Articles
• p73 Is Regulated by Phosphorylation at the G2/M Transition  Journal Articles
• p73 and p63: Why Do We Still Need Them?  Journal Articles