CNS tumor with BCOR internal tandem duplication

Abstract

CNS tumor with BCOR internal tandem duplication is a recently proposed malignant tumor. The patient was an 18-month-old boy with torticollis and vomiting due to cerebellar hemispheric mass with extension to cerebellopontine angle and foramen magnum. Histopathologic examination of the tumor showed a moderately cellular tumor with microcystic formation, myxoid change, and atypical rosettes resembling Homer Wright rosettes. Illumina TruSight RNA Pan-Cancer NGS of the tumor genome revealed BCOR gene exon 15 internal tandem duplications.

Authors

Hazrati L-N; Monajemzadeh M; Habibi Z; Moeini B; Safavi M

Journal

Child's Nervous System, Vol. 39, No. 2, pp. 321–324

Publisher

Springer Nature

Publication Date

February 1, 2023

DOI

10.1007/s00381-022-05796-x

ISSN

0256-7040

Associated Experts

Maryam Monajemzadeh

Assistant Professor, Faculty of Health Sciences

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