Journal article
Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells
Abstract
Overexpression of antiapoptotic proteins including Bcl-XL and/or Bcl-2 contributes to tumor initiation, progression, and resistance to therapy by direct interactions with proapoptotic BH3 proteins. Release of BH3 proteins from antiapoptotic proteins kills some cancer cells and sensitizes others to chemotherapy. Binding of Bcl-XL and Bcl-2 to the BH3 proteins Bad, Bid, and the three major isoforms of Bim was measured for fluorescent protein …
Authors
Aranovich A; Liu Q; Collins T; Geng F; Dixit S; Leber B; Andrews DW
Journal
Molecular Cell, Vol. 45, No. 6, pp. 754–763
Publisher
Elsevier
Publication Date
3 2012
DOI
10.1016/j.molcel.2012.01.030
ISSN
1097-2765
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceApoptosisApoptosis Regulatory ProteinsBH3 Interacting Domain Death Agonist ProteinBacterial ProteinsBcl-2-Like Protein 11Biphenyl CompoundsBreast NeoplasmsCell Line, TumorFemaleFluorescence Resonance Energy TransferHumansLuminescent ProteinsMembrane ProteinsMitochondriaMolecular Sequence DataNitrophenolsPiperazinesProtein Interaction MapsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Sulfonamidesbcl-Associated Death Proteinbcl-X Protein