Journal article
Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter*
Abstract
Tissue inhibitor of metalloproteinases-1 (TIMP-1) can be regulated by gp130 cytokines such as IL-6 and oncostatin M (OSM). Polymerase chain reaction deletion analysis of the murine TIMP-1 proximal promoter in chloramphenicol acetyltransferase reporter gene constructs identified an AP-1 element (-59/-53) that allows maximal responsiveness to OSM in HepG2 cells. Fos and Jun nuclear factors bound constitutively to this site as identified by …
Authors
Botelho FM; Edwards DR; Richards CD
Journal
Journal of Biological Chemistry, Vol. 273, No. 9, pp. 5211–5218
Publisher
Elsevier
Publication Date
February 1998
DOI
10.1074/jbc.273.9.5211
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBinding SitesBinding, CompetitiveCell NucleusCytokinesGene Expression Regulation, NeoplasticGenes, ReporterHumansInterleukin-6MiceOncostatin MPeptidesPromoter Regions, GeneticProtein BindingProto-Oncogene ProteinsProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSp1 Transcription FactorTetradecanoylphorbol AcetateTissue Inhibitor of Metalloproteinase-1Transcription Factor AP-1Transcription FactorsTranscription, GeneticTumor Cells, Cultured