Journal article
BH3-only proteins: Orchestrators of apoptosis
Abstract
The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 family members is critical for understanding the core machinery that controls commitment to apoptosis by permeabilizing the mitochondrial outer membrane. BH3-only proteins promote apoptosis by both directly activating Bax and Bak and by suppressing the …
Authors
Shamas-Din A; Brahmbhatt H; Leber B; Andrews DW
Journal
Biochimica et Biophysica Acta, Vol. 1813, No. 4, pp. 508–520
Publisher
Elsevier
Publication Date
April 2011
DOI
10.1016/j.bbamcr.2010.11.024
ISSN
0006-3002