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BH3-only proteins: Orchestrators of apoptosis
Journal article

BH3-only proteins: Orchestrators of apoptosis

Abstract

The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 family members is critical for understanding the core machinery that controls commitment to apoptosis by permeabilizing the mitochondrial outer membrane. BH3-only proteins promote apoptosis by both directly activating Bax and Bak and by suppressing the …

Authors

Shamas-Din A; Brahmbhatt H; Leber B; Andrews DW

Journal

Biochimica et Biophysica Acta, Vol. 1813, No. 4, pp. 508–520

Publisher

Elsevier

Publication Date

April 2011

DOI

10.1016/j.bbamcr.2010.11.024

ISSN

0006-3002