Journal article
Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.
Abstract
The expression of Bcl-2, Bcl-X, Mcl-1, and Bax was examined by immunohistochemical methods in 93 tumors of nervous system origin, including 49 gliomas (30 astrocytomas and 19 glioblastoma multiforme (GMs)), 16 medulloblastomas (MBs), 19 neuroblastomas (NBs; 9 undifferentiated and 10 differentiated), and 9 miscellaneous neuroectodermal neoplasms. Among the 49 gliomas, immunopositivity (defined as > or = 10%) was observed for Bcl-2 in 45 (92%), …
Authors
Krajewski S; Krajewska M; Ehrmann J; Sikorska M; Lach B; Chatten J; Reed JC
Journal
American Journal Of Pathology, Vol. 150, No. 3, pp. 805–814
Publication Date
March 1997
ISSN
0002-9440
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Central Nervous System NeoplasmsGene Expression Regulation, NeoplasticGliomaHumansImmunohistochemistryMedulloblastomaMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsNeuroblastomaNeuroectodermal TumorsPeripheral Nervous System NeoplasmsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2bcl-2-Associated X Proteinbcl-X Protein