Journal article
Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells
Abstract
The master regulatory gene Bmi1 modulates key stem cell properties in neural precursor cells (NPCs), and has been implicated in brain tumorigenesis. We previously identified a population of CD133+ brain tumor cells possessing stem cell properties, known as brain tumor initiating cells (BTICs). Here, we characterize the expression and role of Bmi1 in primary minimally cultured human glioblastoma (GBM) patient isolates in CD133+ and CD133- sorted …
Authors
Venugopal C; Li N; Wang X; Manoranjan B; Hawkins C; Gunnarsson T; Hollenberg R; Klurfan P; Murty N; Kwiecien J
Journal
Stem Cell Research, Vol. 8, No. 2, pp. 141–153
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.scr.2011.09.008
ISSN
1873-5061
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AC133 AntigenAdultAgedAntigens, CDBrain NeoplasmsCell DifferentiationCell SeparationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlycoproteinsHumansMaleMiddle AgedNeoplastic Stem CellsNuclear ProteinsPeptidesPolycomb Repressive Complex 1Proto-Oncogene ProteinsRNA, Small InterferingRepressor ProteinsSpheroids, CellularTreatment OutcomeTumor Cells, Cultured