Journal article
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Abstract
Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and …
Authors
Zhai G; Teumer A; Stolk L; Perry JRB; Vandenput L; Coviello AD; Koster A; Bell JT; Bhasin S; Eriksson J
Journal
PLOS Genetics, Vol. 7, No. 4,
Publisher
Public Library of Science (PLoS)
Publication Date
April 2011
DOI
10.1371/journal.pgen.1002025
ISSN
1553-7390
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Actin-Related Protein 2-3 ComplexAdaptor Proteins, Signal TransducingAdultAgedAgingApoptosis Regulatory ProteinsAryl Hydrocarbon HydroxylasesBcl-2-Like Protein 11Cytochrome P-450 CYP2C9DNA-Binding ProteinsDehydroepiandrosterone SulfateFemaleGene ExpressionGenome-Wide Association StudyHomeodomain ProteinsHumansKruppel-Like Transcription FactorsLinkage DisequilibriumLiverMaleMembrane ProteinsMiddle AgedPolymorphism, Single NucleotideProto-Oncogene ProteinsSulfotransferasesTranscription FactorsWhite PeopleYoung Adult