Small molecules reveal an alternative mechanism of Bax activation Academic Article uri icon

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abstract

  • We identified five structurally different compounds that trigger the pro-apoptotic protein Bax to permeabilize mitochondrial outer membranes leading to cellular demise. The molecular mechanisms by which these compounds and pro-apoptotic BH3 proteins trigger pore formation by Bax are different.

authors

  • Brahmbhatt, Hetal
  • Uehling, David
  • Al-awar, Rima
  • Leber, Brian
  • Andrews, David

publication date

  • April 15, 2016