Hirudins Concept

subject area of

• A Control Switch for Prothrombinase  Journal Articles
• A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss  Journal Articles
• A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo  Journal Articles
• A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models  Journal Articles
• Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and d-Phe-Pro-Arg-Ch2Cl  Journal Articles
• Advances in Antithrombotic Therapy: Novel Agents  Journal Articles
• American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia  Journal Articles
• Anticoagulant Actions of Tissue Factor Pathway Inhibitor on Tissue-Factor-Dependent Plasma Coagulation  Journal Articles
• Anticoagulants in acute coronary syndromes  Journal Articles
• Anticoagulation for cardiopulmonary bypass: Is a replacement for heparin on the horizon?  Journal Articles
• Antithrombotic Therapy During Percutaneous Coronary Intervention  Journal Articles
• Autoimmune heparin‐induced thrombocytopenia and venous limb gangrene after aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin  Journal Articles
• Beyond Heparin and Aspirin  Journal Articles
• Beyond Unfractionated Heparin and Warfarin  Journal Articles
• Bivalent direct thrombin inhibitors: hirudin and bivalirudin  Journal Articles
• Bivalirudin  Journal Articles
• Bivalirudin in patients with heparin-induced thrombocytopenia undergoing percutaneous coronary intervention.  Journal Articles
• Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention in Patients with Non‐ST‐Segment Elevation Acute Coronary Syndrome Initially Treated with Fondaparinux: Results from an International, Multicenter, Randomized Pilot Study (SWITCH III)  Journal Articles
• Bivalirudin, thrombin and platelets: clinical implications and future directions.  Journal Articles
• Bivalirudin: a review  Journal Articles
• Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.  Journal Articles
• Combined administration of barbourin–albumin and hirudin–albumin fusion proteins limits fibrin(ogen) deposition on the rabbit balloon-injured aorta  Journal Articles
• Comment: Treatment of Heparin-Induced Thrombocytopenia  Journal Articles
• Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events [REPLACE]-1 trial)  Journal Articles
• Comparison of the Effects of Heparin and Hirudin on Thrombin Binding to the Normal and the De-Endothelialized Rabbit Aorta In Vitro  Journal Articles
• Comparison of the Effects of Two Doses of Recombinant Hirudin Compared With Heparin in Patients With Acute Myocardial Ischemia Without ST Elevation  Journal Articles
• Conditions Affecting the Responses of Human Platelets to Epinephrine  Journal Articles
• Conformational Changes in Thrombin When Complexed by Serpins  Journal Articles
• Coordinate Activation of Human Platelet Protease-activated Receptor-1 and -4 in Response to Subnanomolar α-Thrombin  Journal Articles
• Current agents for the treatment of patients with heparin-induced thrombocytopenia  Journal Articles
• Design, baseline characteristics, and preliminary clinical results of the Organization to Assess Strategies for Ischemic Syndromes–2 (OASIS–2) trial  Journal Articles
• Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation  Journal Articles
• Direct Thrombin Inhibitors  Conferences
• Direct Thrombin Inhibitors in Cardiac Disease  Journal Articles
• Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin  Conferences
• Direct thrombin inhibitors in acute coronary syndromes  Journal Articles
• Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data  Journal Articles
• Displacement of Fibrin-bound Thrombin by r-Hirudin Precludes the Use of 131l-r-Hirudin for Detecting Pulmonary Emboli in the Rabbit  Journal Articles
• EFFECT OF SERA ON THROMBIN ACTIVATION RATE CONSTANTS: A ONE‐STAGE ASSAY OF THE EXTRINSIC SYSTEM  Journal Articles
• Effects of long-term, moderate-intensity oral anticoagulation in addition to aspirin in unstable angina  Journal Articles
• Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial  Journal Articles
• Effects on Thrombin Generation of Single Injections of Hirulog™ in Patients with Calf Vein Thrombosis  Journal Articles
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin  Journal Articles
• Factors responsible for ADP-induced release reaction of human platelets  Other
• Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists  Journal Articles
• Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT) – Bridging the River Coumarin  Journal Articles
• Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition  Journal Articles
• HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase  Journal Articles
• HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions  Journal Articles
• Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment  Journal Articles
• Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma  Journal Articles
• Heparin compromises streptokinase-induced arterial patency in rabbits  Journal Articles
• Heparin resistance in acute coronary syndromes  Journal Articles
• Heparin-Induced Thrombocytopenia  Journal Articles
• Heparin-Induced Thrombocytopenia: A Ten-Year Retrospective  Journal Articles
• Heparin-induced thrombocytopenia and cardiac surgery  Journal Articles
• Heparin-induced thrombocytopenia and cardiac surgery  Journal Articles
• Heparin-induced thrombocytopenia and its treatment.  Conferences
• Heparin-induced thrombocytopenia in intensive care patients  Journal Articles
• Heparin-induced thrombocytopenia in the critical care setting: Diagnosis and management^  Journal Articles
• Heparin‐induced thrombocytopenia: pathogenesis and management  Journal Articles
• Hirudin and thrombosis prophylaxis  Journal Articles
• Hirudin causes more bleeding than heparin in a rabbit ear bleeding model  Journal Articles
• Hirulog in the Treatment of Unstable Angina  Journal Articles
• INHIBITION OF THROMBIN BY HIRUDIN GENETICALLY FUSED TO WILD-TYPE OR MUTANT ANTITHROMBIN  Journal Articles
• Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of α-thrombin  Journal Articles
• Long-Term Oral Anticoagulant Therapy in Patients With Unstable Angina or Suspected Non–Q-Wave Myocardial Infarction  Journal Articles
• Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban  Journal Articles
• Meta-Analysis Comparing Bivalirudin Versus Heparin Monotherapy on Ischemic and Bleeding Outcomes After Percutaneous Coronary Intervention  Journal Articles
• Meta-Analysis of Effects of Bivalirudin Versus Heparin on Myocardial Ischemic and Bleeding Outcomes After Percutaneous Coronary Intervention  Journal Articles
• Modulation of the Enzymatic Activity of α-Thrombin by Polyanions: Consequences on Intrinsic Activation of Factor V and Factor VIII  Journal Articles
• Otamixaban in acute coronary syndromes  Journal Articles
• Parenteral Anticoagulants  Journal Articles
• Parenteral Anticoagulants  Journal Articles
• Pharmacokinetic Optimisation of the Treatment of Deep Vein Thrombosis  Journal Articles
• Potent Antithrombin Activity and Delayed Clearance From the Circulation Characterize Recombinant Hirudin Genetically Fused to Albumin  Journal Articles
• Pretreatment of Rabbits With Either Hirudin, Ancrod, or Warfarin Significantly Reduces the Immediate Uptake of Fibrinogen and Platelets by the Deendothelialized Aorta Wall After Balloon-Catheter Injury In Vivo  Journal Articles
• Prolonged in vivo anticoagulant activity of a hirudin–albumin fusion protein secreted from Pichia pastoris  Journal Articles
• Radiolabeled r-Hirudin as a Measure of Thrombin Activity at, or within, the Rabbit Aorta Wall In Vitro and In Vivo  Journal Articles
• Randomized Comparison of Direct Thrombin Inhibition Versus Heparin in Conjunction With Fibrinolytic Therapy for Acute Myocardial Infarction: Results From the GUSTO-IIb Trial  Journal Articles
• Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators.  Journal Articles
• Reactions of Polylysine with Human Platelets in Plasma and in Suspensions of Washed Platelets  Journal Articles
• Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial  Journal Articles
• Risk of Stent Thrombosis and Major Bleeding with Bivalirudin Compared with Active Control: A Systematic Review and Meta-analysis of Randomized Trials  Journal Articles
• Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence  Journal Articles
• Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact  Journal Articles
• Sustained antithrombotic activity of hirudin after its plasma clearance: comparison with heparin  Journal Articles
• The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene \textbar Request PDF  Journal Articles
• The Emerging Role of Immunoregulation of Fibrinogen‐Related Procoagulant Fgl2 in the Success or Spontaneous Abortion of Early Pregnancy in Mice and Humans  Journal Articles
• The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model  Journal Articles
• The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand  Journal Articles
• The direct thrombin inhibitor hirudin  Journal Articles
• The evolving role of direct thrombin inhibitors in acute coronary syndromes  Journal Articles
• The evolving role of direct thrombin inhibitors in acute coronary syndromes.  Journal Articles
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase  Journal Articles
• The organization to assess strategies for ischemic syndromes (OASIS) pilot study: evaluation of acute and long-term therapies for patients with acute coronary syndromes without ST elevation  Journal Articles
• Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin  Journal Articles
• Thrombin and Antithrombotics  Journal Articles
• Thrombin binding to platelets and their activation in plasma  Journal Articles
• Thrombin structure and function  Journal Articles
• Ticlopidine Facilitates the Deaggregation of Human Platelets Aggregated by Thrombin \textbar Request PDF  Other
• Transient Global Amnesia as the Presenting Feature of Heparin-Induced Thrombocytopenia  Journal Articles
• Translational Success Stories  Journal Articles
• Treatment of Heparin-Induced Thrombocytopenia  Journal Articles
• Unstable angina.  Journal Articles
• Unstable angina.  Journal Articles
• Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.  Journal Articles
• Vasoflux, a New Anticoagulant With a Novel Mechanism of Action  Journal Articles
• Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin‐induced thrombocytopenia  Journal Articles
• Which antithrombotic to use during PCI?  Journal Articles