Pharmacokinetic Optimisation of the Treatment of Deep Vein Thrombosis

The current treatment for deep vein thrombosis is a 5-to 10-day course of heparin followed by 3 to 6 months of oral anticoagulants. Both heparin and oral anticoagulants present a high inter- and intra-individual variability and require individualisation and monitoring of their dosage.The pharmacokinetic properties of heparin have been difficult to assess through the radiolabelling procedures typically used for many other drugs. This is …