Journal article
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models
Abstract
The leech protein hirudin is a potent natural thrombin inhibitor. Its potential as an antithrombotic agent is limited by its promotion of bleeding. We attempted to modify this profile by positioning albumin and a plasmin cleavage site on its N-terminus, in recombinant protein HSACHV3 [comprising hirudin variant 3 (HV3) fused to the C-terminus of human serum albumin (HSA) via a plasmin cleavage site (C)], Previously we showed that HSACHV3 …
Authors
Sheffield WP; Eltringham-Smith LJ; Gataiance S; Bhakta V
Journal
Journal of Thrombosis and Thrombolysis, Vol. 39, No. 4, pp. 443–451
Publisher
Springer Nature
Publication Date
May 2015
DOI
10.1007/s11239-014-1157-3
ISSN
0929-5305