Adaptor Proteins, Signal Transducing Concept

subject area of

• 15q11.2 microdeletion (BP1–BP2) and developmental delay, behaviour issues, epilepsy and congenital heart disease: A series of 52 patients  Journal Articles
• MCM7and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer  Journal Articles
• YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins  Journal Articles
• A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer  Journal Articles
• A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor  Journal Articles
• A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia  Journal Articles
• A role for the TGFβ-Par6 polarity pathway in breast cancer progression  Journal Articles
• Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression  Journal Articles
• Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis  Journal Articles
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Journal Articles
• An HLA-G/SPAG9/STAT3 axis promotes brain metastases  Journal Articles
• Association study of brain‐derived neurotrophic factor (BDNF) and LIN‐7 homolog (LIN‐7) genes with adult attention‐deficit/hyperactivity disorder  Journal Articles
• At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes  Journal Articles
• Blood flow reprograms lymphatic vessels to blood vessels  Journal Articles
• CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection  Journal Articles
• CNKSR2-Related Developmental and Epileptic Encephalopathy with Spike-Wave Activation in Sleep: A Report of Two Additional Cases and Review of the Literature  Journal Articles
• CYFIP/Sra-1 Controls Neuronal Connectivity in Drosophila and Links the Rac1 GTPase Pathway to the Fragile X Protein  Journal Articles
• Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans  Journal Articles
• Chronic β₂-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca²⁺-ATPase protein and activity  Journal Articles
• Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial–lysosomal axis and alleviates autophagic blockage in Pompe disease  Journal Articles
• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease  Journal Articles
• Control of Pathogenic CD4 T Cells and Lethal Immunopathology by Signaling Immunoadaptor DAP12 during Influenza Infection  Journal Articles
• Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers  Journal Articles
• Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection  Journal Articles
• Cycloheximide-induced T-cell Death Is Mediated by a Fas-associated Death Domain-dependent Mechanism  Journal Articles
• Detection of an Involvement of the Human Mismatch Repair Genes hMLH1 and hMSH2 in Nucleotide Excision Repair Is Dependent on UVC Fluence to Cells  Journal Articles
• Differential Regulation of DAP12 and Molecules Associated with DAP12 during Host Responses to Mycobacterial Infection  Journal Articles
• Differential sclerostin and parathyroid hormone response to exercise in boys and men  Journal Articles
• Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice  Journal Articles
• Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms  Journal Articles
• Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men1–3  Journal Articles
• Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression  Journal Articles
• Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity  Journal Articles
• Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia  Journal Articles
• GABARAP is a determinant of apoptosis in growth-arrested chicken embryo fibroblasts  Journal Articles
• Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation  Journal Articles
• Genetic bases of hypertriglyceridemic phenotypes  Journal Articles
• Genetic determinants of plasma triglycerides  Journal Articles
• Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci  Journal Articles
• Genome-wide association study of sepsis in extremely premature infants  Journal Articles
• Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells  Journal Articles
• IDH1 R132C and ERC2 L309I Mutations Contribute to the Development of Maffucci’s Syndrome  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Induction of Flexibility through Protein-Protein Interactions  Journal Articles
• Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis  Journal Articles
• Long Double-Stranded RNA Induces an Antiviral Response Independent of IFN Regulatory Factor 3, IFN-β Promoter Stimulator 1, and IFN  Journal Articles
• Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia  Journal Articles
• Modulation of Hepatic Granulomatous Responses by Transgene Expression of DAP12 or TREM-1-Ig Molecules  Journal Articles
• Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers  Journal Articles
• Mutations in the Chromatin Regulator Gene BRPF1 Cause Syndromic Intellectual Disability and Deficient Histone Acetylation  Journal Articles
• New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes  Journal Articles
• PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop  Journal Articles
• Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages  Journal Articles
• Phase II Study of Lapatinib in Recurrent or Metastatic Epidermal Growth Factor Receptor and/or erbB2 Expressing Adenoid Cystic Carcinoma and Non–Adenoid Cystic Carcinoma Malignant Tumors of the Salivary Glands  Journal Articles
• Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity  Journal Articles
• Polygenic determinants of severe hypertriglyceridemia  Journal Articles
• Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin  Journal Articles
• Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells  Journal Articles
• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease  Journal Articles
• Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor  Journal Articles
• Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α and liver-X-receptor α  Journal Articles
• Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2  Journal Articles
• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation  Journal Articles
• Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis  Journal Articles
• Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers  Journal Articles
• Role of DAP12 in Innate and Adaptive Immune Responses  Journal Articles
• Sam68 Allows Selective Targeting of Human Cancer Stem Cells  Journal Articles
• Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse  Journal Articles
• Skeletal Muscle Mitochondrial Morphology Negatively Affected in Mice Lacking Xin  Journal Articles
• Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology  Journal Articles
• Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer.  Journal Articles
• The Drosophila Gene RanBPM Functions in the Mushroom Body to Regulate Larval Behavior  Journal Articles
• The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO  Journal Articles
• The Unc-119 Family of Neural Proteins is Functionally Conserved Between Humans,DrosophilaandC. Elegans  Journal Articles
• The eosinophil actin cytoskeleton undergoes rapid rearrangement in response to fluid shear stress  Journal Articles
• The genetic landscape of developmental and epileptic encephalopathy with spike-and-wave activation in sleep  Journal Articles
• The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex  Journal Articles
• The p56 -interacting Protein p62 Stimulates Transcription via the SV40 Enhancer  Journal Articles
• Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73  Journal Articles
• Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) Modulates Immune Responses toAspergillus fumigatusDuring Fungal Asthma in Mice  Journal Articles
• Tyrosine 740 Phosphorylation of Discoidin Domain Receptor 2 by Src Stimulates Intramolecular Autophosphorylation and Shc Signaling Complex Formation  Journal Articles
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Journal Articles
• Using chemical exchange to assign non-covalent protein complexes in slow exchange with the free state: Enhanced resolution and efficient signal editing  Journal Articles
• YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers  Journal Articles
• YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer  Journal Articles
• YAP1 Meets Tumor Suppression  Journal Articles
• p73-induced apoptosis: A question of compartments and cooperation  Journal Articles
• p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade  Journal Articles
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Journal Articles