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Rare coding variants in PLCG2, ABI3, and TREM2...
Journal article

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Abstract

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Authors

Sims R; van der Lee SJ; Naj AC; Bellenguez C; Badarinarayan N; Jakobsdottir J; Kunkle BW; Boland A; Raybould R; Bis JC

Journal

Nature Genetics, Vol. 49, No. 9, pp. 1373–1384

Publisher

Springer Nature

Publication Date

September 1, 2017

DOI

10.1038/ng.3916

ISSN

1061-4036

Associated Experts

James Raymond Gilbert

Professor Emeritus, Faculty of Health Sciences
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Labels

Fields of Research (FoR)

31 Biological Sciences3105 Genetics3001 Agricultural biotechnology3102 Bioinformatics and computational biology

Medical Subject Headings (MeSH)

Adaptor Proteins, Signal TransducingAlzheimer DiseaseAmino Acid SequenceCase-Control StudiesExomeGene Expression ProfilingGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansImmunity, InnateLinkage DisequilibriumMembrane GlycoproteinsMicrogliaOdds RatioPhospholipase C gammaPolymorphism, Single NucleotideProtein Interaction MapsReceptors, ImmunologicSequence Homology, Amino Acid
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