Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Academic Article uri icon

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abstract

  • The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

authors

  • Naj, Adam C
  • Jun, Gyungah
  • Beecham, Gary W
  • Wang, Li-San
  • Vardarajan, Badri Narayan
  • Buros, Jacqueline
  • Gallins, Paul J
  • Buxbaum, Joseph D
  • Jarvik, Gail P
  • Crane, Paul K
  • Larson, Eric B
  • Bird, Thomas D
  • Boeve, Bradley F
  • Graff-Radford, Neill R
  • De Jager, Philip L
  • Evans, Denis
  • Schneider, Julie A
  • Carrasquillo, Minerva M
  • Ertekin-Taner, Nilufer
  • Younkin, Steven G
  • Cruchaga, Carlos
  • Kauwe, John SK
  • Nowotny, Petra
  • Kramer, Patricia
  • Hardy, John
  • Huentelman, Matthew J
  • Myers, Amanda J
  • Barmada, Michael M
  • Demirci, F Yesim
  • Baldwin, Clinton T
  • Green, Robert C
  • Rogaeva, Ekaterina
  • George-Hyslop, Peter St
  • Arnold, Steven E
  • Barber, Robert
  • Beach, Thomas
  • Bigio, Eileen H
  • Bowen, James D
  • Boxer, Adam
  • Burke, James R
  • Cairns, Nigel J
  • Carlson, Chris S
  • Carney, Regina M
  • Carroll, Steven L
  • Chui, Helena C
  • Clark, David G
  • Corneveaux, Jason
  • Cotman, Carl W
  • Cummings, Jeffrey L
  • DeCarli, Charles
  • DeKosky, Steven T
  • Diaz-Arrastia, Ramon
  • Dick, Malcolm
  • Dickson, Dennis W
  • Ellis, William G
  • Faber, Kelley M
  • Fallon, Kenneth B
  • Farlow, Martin R
  • Ferris, Steven
  • Frosch, Matthew P
  • Galasko, Douglas R
  • Ganguli, Mary
  • Gearing, Marla
  • Geschwind, Daniel H
  • Ghetti, Bernardino
  • Gilbert, James Raymond
  • Gilman, Sid
  • Giordani, Bruno
  • Glass, Jonathan D
  • Growdon, John H
  • Hamilton, Ronald L
  • Harrell, Lindy E
  • Head, Elizabeth
  • Honig, Lawrence S
  • Hulette, Christine M
  • Hyman, Bradley T
  • Jicha, Gregory A
  • Jin, Lee-Way
  • Johnson, Nancy
  • Karlawish, Jason
  • Karydas, Anna
  • Kaye, Jeffrey A
  • Kim, Ronald
  • Koo, Edward H
  • Kowall, Neil W
  • Lah, James J
  • Levey, Allan I
  • Lieberman, Andrew P
  • Lopez, Oscar L
  • Mack, Wendy J
  • Marson, Daniel C
  • Martiniuk, Frank
  • Mash, Deborah C
  • Masliah, Eliezer
  • McCormick, Wayne C
  • McCurry, Susan M
  • McDavid, Andrew N
  • McKee, Ann C
  • Mesulam, Marsel
  • Miller, Bruce L
  • Miller, Carol A
  • Miller, Joshua W
  • Parisi, Joseph E
  • Perl, Daniel P
  • Peskind, Elaine
  • Petersen, Ronald C
  • Poon, Wayne W
  • Quinn, Joseph F
  • Rajbhandary, Ruchita A
  • Raskind, Murray
  • Reisberg, Barry
  • Ringman, John M
  • Roberson, Erik D
  • Rosenberg, Roger N
  • Sano, Mary
  • Schneider, Lon S
  • Seeley, William
  • Shelanski, Michael L
  • Slifer, Michael A
  • Smith, Charles D
  • Sonnen, Joshua A
  • Spina, Salvatore
  • Stern, Robert A
  • Tanzi, Rudolph E
  • Trojanowski, John Q
  • Troncoso, Juan C
  • Van Deerlin, Vivianna M
  • Vinters, Harry V
  • Vonsattel, Jean Paul
  • Weintraub, Sandra
  • Welsh-Bohmer, Kathleen A
  • Williamson, Jennifer
  • Woltjer, Randall L
  • Cantwell, Laura B
  • Dombroski, Beth A
  • Beekly, Duane
  • Lunetta, Kathryn L
  • Martin, Eden R
  • Kamboh, M Ilyas
  • Saykin, Andrew J
  • Reiman, Eric M
  • Bennett, David A
  • Morris, John C
  • Montine, Thomas J
  • Goate, Alison M
  • Blacker, Deborah
  • Tsuang, Debby W
  • Hakonarson, Hakon
  • Kukull, Walter A
  • Foroud, Tatiana M
  • Haines, Jonathan L
  • Mayeux, Richard
  • Pericak-Vance, Margaret A
  • Farrer, Lindsay A
  • Schellenberg, Gerard D

publication date

  • May 2011

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