Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis Academic Article uri icon

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abstract

  • Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

authors

  • Carpenter, KJ
  • Buckland, KF
  • Xing, Zhou
  • Hogaboam, CM

publication date

  • December 1, 2005