Intrapulmonary, Adenovirus-Mediated Overexpression...

Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis

Abstract

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

Authors

Carpenter KJ; Buckland KF; Xing Z; Hogaboam CM

Journal

Infection and Immunity, Vol. 73, No. 12, pp. 8402–8406

Publisher

American Society for Microbiology

Publication Date

December 1, 2005

DOI

10.1128/iai.73.12.8402-8406.2005

ISSN

0019-9567

Associated Experts

Zhou Xing

Professor, Faculty of Health Sciences

Visit profile

Labels