Journal article
Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci
Abstract
Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To comprehensively address this issue, we performed a genome-wide association analysis of sICAM-1 concentration in 22,435 apparently healthy women from the …
Authors
Paré G; Ridker PM; Rose L; Barbalic M; Dupuis J; Dehghan A; Bis JC; Benjamin EJ; Shiffman D; Parker AN
Journal
PLOS Genetics, Vol. 7, No. 4,
Publisher
Public Library of Science (PLoS)
Publication Date
April 2011
DOI
10.1371/journal.pgen.1001374
ISSN
1553-7390
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
ABO Blood-Group SystemAdaptor Proteins, Signal TransducingCohort StudiesFemaleGene FrequencyGenetic LociGenome, HumanGenome-Wide Association StudyGenotypeHumansI-kappa B KinaseIntercellular Adhesion Molecule-1Intracellular Signaling Peptides and ProteinsLipaseMembrane ProteinsModels, GeneticMultifactorial InheritancePolymorphism, Single NucleotideProteinsTranscription Factor RelA