Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice Journal Articles

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abstract

The NleGs are the largest family of type 3 secreted effectors in attaching and effacing (A/E) pathogens, such as enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli , and Citrobacter rodentium . NleG effectors contain a conserved C-terminal U-box domain acting as a ubiquitin protein ligase and target host proteins via a variable N-terminal portion.

authors

Popov, Georgy
Fiebig-Comyn, Aline
Syriste, Lukas
Little, Dustin J
Skarina, Tatiana
Stogios, Peter J
Birstonas, Sarah
Coombes, Brian
Savchenko, Alexei

status

published

publication date

January 24, 2023

has subject area

06 Biological Sciences (FoR)
07 Agricultural and Veterinary Sciences (FoR)
11 Medical and Health Sciences (FoR)
Adaptor Proteins, Signal Transducing (MeSH)
Animals (MeSH)
Biological Transport (MeSH)
Citrobacter rodentium (MeSH)
Enterobacteriaceae Infections (MeSH)
Enterohemorrhagic Escherichia coli (MeSH)
Enteropathogenic Escherichia coli (MeSH)
Escherichia coli Proteins (MeSH)
Golgi Matrix Proteins (MeSH)
Humans (MeSH)
Mice (MeSH)
Microbiology (Science Metrix)

published in

Infection and Immunity Journal