selected scholarly activity
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academic article
- Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. European Heart Journal. 44:3040-3058. 2023
- Investigation of the pathological effects of histones, DNA, and nucleosomes in a murine model of sepsis. Shock. Publish Ahead of Print:291-297. 2023
- Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions. Intensive Care Medicine Experimental. 11:45. 2023
- THE EFFECTS OF DNASE I AND LOW-MOLECULAR-WEIGHT HEPARIN IN A MURINE MODEL OF POLYMICROBIAL ABDOMINAL SEPSIS. Shock. 59:666-672. 2023
- Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol. Systematic Reviews. 12:50. 2023
- Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering. 22:2566-2577. 2022
- Investigations of the effectiveness of heparin variants as inhibitors of histones. Journal of Thrombosis and Haemostasis. 20:1485-1495. 2022
- Single-step measurement of cell-free DNA for sepsis prognosis using a thread-based microfluidic device. Microchimica Acta: an international journal on micro and trace analysis. 189:146. 2022
- Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging. Circulation Research. 130:252-272. 2022
- Immunothrombosis Biomarkers for Distinguishing Coronavirus Disease 2019 Patients From Noncoronavirus Disease Septic Patients With Pneumonia and for Predicting ICU Mortality. Critical Care Explorations. 3:e0588-e0588. 2021
- Mechanistic Studies of DNase I Activity: Impact of Heparin Variants and PAD4. Shock. 56:975-987. 2021
- National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Medicine Experimental. 9:14. 2021
- Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: A single‐center prospective longitudinal study. Journal of Thrombosis and Haemostasis. 19:1546-1557. 2021
- The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis. Critical Care Explorations. 3:e0433-e0433. 2021
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers. 330:129265-129265. 2021
- Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients. PLoS One. 16:e0247017-e0247017. 2021
- Hypercoagulability and coronavirus disease 2019–associated hypoxemic respiratory failure: Mechanisms and emerging management paradigms. The Journal of Trauma and Acute Care Surgery. 89:e177-e181. 2020
- Identification of hemostatic markers that define the pre‐DIC state: A multi‐center observational study. Journal of Thrombosis and Haemostasis. 18:2524-2531. 2020
- Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Canadian Journal of Anaesthesia. 67:475-484. 2020
- Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism?. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 186:13-19. 2020
- Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*. Critical Care Medicine. 48:142-150. 2020
- Comparison of the source and prognostic utility of cfDNA in trauma and sepsis. Intensive Care Medicine Experimental. 7:29. 2019
- Purification of silica‐free DNA and characterization of its role in coagulation. Journal of Thrombosis and Haemostasis. 17:1860-1865. 2019
- <p>Modulation of Human Neutrophil Peptides on <em>P. aeruginosa</em> Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles</p>. Journal of Inflammation Research. Volume 12:335-343. 2019
- Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis. Intensive Care Medicine Experimental. 6:20. 2018
- Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. Critical Care Medicine. 46:e921-e927. 2018
- Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8:10496. 2018
- Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism. Blood. 131:2151-2160. 2018
- Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia. Critical Care (UK). 21:97. 2017
- Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis. Intensive Care Medicine Experimental. 5:5. 2017
- DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. American Journal of Respiratory and Critical Care Medicine. 195:889-905. 2017
- The impact of the endothelial protein C receptor on thrombin generation and clot lysis. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 152:30-37. 2017
- Procoagulant effects of lung cancer chemotherapy. Blood Coagulation and Fibrinolysis: international journal in haemostasis and thrombosis. 28:72-82. 2017
- A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials. 17:556. 2016
- Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis. Shock. 46:672-680. 2016
- Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes. Shock. 46:655-662. 2016
- Histones link inflammation and thrombosis through the induction of Weibel–Palade body exocytosis. Journal of Thrombosis and Haemostasis. 14:2274-2286. 2016
- D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 146:119-125. 2016
- Quantification of Cell-Free DNA in Red Blood Cell Units in Different Whole Blood Processing Methods. Journal of Blood Transfusion. 2016:1-5. 2016
- The role of leukocytes in thrombosis. Blood. 128:753-762. 2016
- DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC. Blood Reviews. 30:257-261. 2016
- Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin. Journal of Cellular and Molecular Medicine. 20:710-720. 2016
- Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells. Journal of Thrombosis and Haemostasis. 14:366-374. 2016
- Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis. Arteriosclerosis, Thrombosis and Vascular Biology. 35:2544-2553. 2015
- Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro. Critical Care (UK). 19:149. 2015
- Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome. Arthritis and Rheumatology. 67:2990-3003. 2015
- A microfluidic device for rapid quantification of cell-free DNA in patients with severe sepsis. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering. 15:3925-3933. 2015
- Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA. Shock. 44:265-271. 2015
- Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis. Shock. 44:166-172. 2015
- Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis. Blood. 126:673-682. 2015
- Extracellular DNA and histones: double‐edged swords in immunothrombosis. Journal of Thrombosis and Haemostasis. 13:S82-S91. 2015
- Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption. Blood Coagulation and Fibrinolysis: international journal in haemostasis and thrombosis. 26:36-45. 2015
- Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 134:1142-1149. 2014
- Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms. Arteriosclerosis, Thrombosis and Vascular Biology. 34:1977-1984. 2014
- The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand. BMC Molecular and Cell Biology. 14:6. 2013
- Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism. Arteriosclerosis, Thrombosis and Vascular Biology. 33:2674-2681. 2013
- Dalteparin Low Molecular Weight Heparin (LMWH) in ovarian cancer: A phase II randomized study. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 130:894-900. 2012
- Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Critical Care (UK). 16:R151-R151. 2012
- Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis. Journal of Critical Care. 26:556-565. 2011
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells. Journal of Thrombosis and Haemostasis. 9:2424-2435. 2011
- Breast cancer chemotherapy induces the release of cell‐free DNA, a novel procoagulant stimulus. Journal of Thrombosis and Haemostasis. 9:2313-2321. 2011
- Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*. Critical Care Medicine. 39:702-710. 2011
- The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal‐based and cell‐based models. Journal of Thrombosis and Haemostasis. 9:767-775. 2011
- Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes. Journal of Thrombosis and Haemostasis. 9:582-592. 2011
- Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients. Pathophysiology of Haemostasis and Thrombosis: international journal on haemostasis and thrombosis research. 37:88-97. 2010
- Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation. Journal of Heart and Lung Transplantation. 28:1180-1184. 2009
- Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes. Journal of Immunology. 181:2165-2173. 2008
- Protective effects of activated protein C in sepsis. Thrombosis and Haemostasis. 100:582-592. 2008
- Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 122:418-426. 2008
- Hepatic leukocyte recruitment in response to time-limited expression of TNF-α and IL-1β. American Journal of Physiology: Gastrointestinal and Liver Physiology. 293:G663-G672. 2007
- Activated protein C in sepsis and beyond: Update 2006. Frontiers in Bioscience-Landmark. 12:1963-1963. 2007
- Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway. Molecular Cancer Therapeutics. 5:3303-3311. 2006
- Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant. Journal of Immunology. 177:2115-2122. 2006
- Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Journal of Experimental Medicine. 203:1447-1458. 2006
- Bone Marrow-Derived Dendritic Cell Vaccination of Dogs with Naturally Occurring Melanoma by Using Human gp100 Antigen. Journal of Veterinary Internal Medicine. 19:56-63. 2005
- Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood. 104:3958-3964. 2004
- Endogenous protein C activation in patients with severe sepsis. Critical Care Medicine. 32:S214-S218. 2004
- A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. Journal of Thrombosis and Haemostasis. 1:662-670. 2003
- Molecular Basis for the Susceptibility of Fibrin-bound Thrombin to Inactivation by Heparin Cofactor II in the Presence of Dermatan Sulfate but Not Heparin. Journal of Biological Chemistry. 276:20959-20965. 2001
- Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor. Journal of Biological Chemistry. 276:8364-8370. 2001
- A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function. Thrombosis and Haemostasis. 86:945-948. 2001
- Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function. Journal of Biological Chemistry. 275:5447-5452. 2000
- Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II. Journal of Biological Chemistry. 274:27597-27604. 1999
- Characterization of the stress-inducing effects of homocysteine. Biochemical Journal. 332:213-221. 1998
- Localization of the Thrombin-binding Domain on Prothrombin Fragment 2. Journal of Biological Chemistry. 273:8932-8939. 1998
- Visual detection method for identifying recombinant bacterial colonies.. BioTechniques: the journal of laboratory technology for bioresearch. 18:380-384. 1995
- Defining the sequence specificity of theSaccharomyces cerevisiae DNA binding protein REB1p by selecting binding sites from random-sequence oligonucleotides. Yeast. 10:771-787. 1994
- TATA-binding protein activates transcription when upstream of a GCN4-binding site in a novel yeast promoter.. Journal of Biological Chemistry. 267:20943-20952. 1992
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chapter
- Coagulation Overview. 543-553. 2006
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conference paper
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers. 2021
- Biological Rational for the Use of Heparin in Septic Shock: Translational Data from the Halo Pilot RCT. Blood. 2336-2336. 2015
- Cell-Free DNA modulates clot structure and impairs fibrinolysis in sepsis. Journal of Thrombosis and Haemostasis. 341-341. 2015
- Impact of PCSK9 in a murine mouse model of sepsis. Journal of Thrombosis and Haemostasis. 379-379. 2015
- Impact of the endothelial protein C receptor in coagulation, inflammation and hematopoiesis. Journal of Thrombosis and Haemostasis. 75-75. 2015
- Procoagulant effects of lung cancer chemotherapy through release of microparticles and cell-free DNA. Journal of Thrombosis and Haemostasis. 309-309. 2015
- Microfluidic device for clinical outcome prediction of severe sepsis. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 1036-1038. 2014
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells. Journal of Thrombosis and Haemostasis. 724-724. 2011
- Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes. Journal of Thrombosis and Haemostasis. 619-626. 2009