selected scholarly activity
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academic article
- Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism.. Blood. 131:2151-2160. 2018
- Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis.. Intensive Care Medicine Experimental. 5:5. 2017
- DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.. American Journal of Respiratory and Critical Care Medicine. 195:889-905. 2017
- The impact of the endothelial protein C receptor on thrombin generation and clot lysis.. Thrombosis Research. 152:30-37. 2017
- Procoagulant effects of lung cancer chemotherapy: impact on microparticles and cell-free DNA.. Blood Coagulation and Fibrinolysis. 28:72-82. 2017
- Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis.. Shock. 46:672-680. 2016
- Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes.. Shock. 46:655-662. 2016
- Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis.. Journal of Thrombosis and Haemostasis. 14:2274-2286. 2016
- D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment.. Thrombosis Research. 146:119-125. 2016
- The role of leukocytes in thrombosis.. Blood. 128:753-762. 2016
- DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC.. Blood Reviews. 30:257-261. 2016
- Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin.. Journal of Cellular and Molecular Medicine. 20:710-720. 2016
- Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells.. Journal of Thrombosis and Haemostasis. 14:366-374. 2016
- Quantification of Cell-Free DNA in Red Blood Cell Units in Different Whole Blood Processing Methods.. Journal of Blood Transfusion. 2016:9316385. 2016
- Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis.. Arteriosclerosis, Thrombosis, and Vascular Biology. 35:2544-2553. 2015
- Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.. Arthritis and Rheumatology. 67:2990-3003. 2015
- A microfluidic device for rapid quantification of cell-free DNA in patients with severe sepsis.. Lab on a Chip - Miniaturisation for Chemistry and Biology. 15:3925-3933. 2015
- Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA.. Shock. 44:265-271. 2015
- Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis.. Shock. 44:166-172. 2015
- Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis.. Blood. 126:673-682. 2015
- Extracellular DNA and histones: double-edged swords in immunothrombosis.. Journal of Thrombosis and Haemostasis. 13 Suppl 1:S82-S91. 2015
- Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro.. Critical Care. 19:149. 2015
- Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption.. Blood Coagulation and Fibrinolysis. 26:36-45. 2015
- Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor.. Thrombosis Research. 134:1142-1149. 2014
- Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms.. Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1977-1984. 2014
- Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism.. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2674-2681. 2013
- The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.. BMC Biochemistry. 14:6. 2013
- Dalteparin low molecular weight heparin (LMWH) in ovarian cancer: a phase II randomized study.. Thrombosis Research. 130:894-900. 2012
- Prognostic utility and characterization of cell-free DNA in patients with severe sepsis.. Critical Care. 16:R151. 2012
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells.. Journal of Thrombosis and Haemostasis. 9:2424-2435. 2011
- Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus.. Journal of Thrombosis and Haemostasis. 9:2313-2321. 2011
- Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.. Critical Care Medicine. 39:702-710. 2011
- The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models.. Journal of Thrombosis and Haemostasis. 9:767-775. 2011
- Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes.. Journal of Thrombosis and Haemostasis. 9:582-592. 2011
- Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients.. Pathophysiology of Haemostasis and Thrombosis Haemostasis. 37:88-97. 2010
- Activated protein C in ischemia-reperfusion injury after experimental lung transplantation.. Journal of Heart and Lung Transplantation Journal of Heart Transplantation. 28:1180-1184. 2009
- Protective effects of activated protein C in sepsis.. Thrombosis and Haemostasis. 100:582-592. 2008
- Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes.. Journal of Immunology. 181:2165-2173. 2008
- Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma.. Thrombosis Research. 122:418-426. 2008
- Activated protein C in sepsis and beyond: update 2006.. Frontiers in Bioscience - Landmark. 12:1963-1972. 2007
- Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway.. Molecular Cancer Therapeutics. 5:3303-3311. 2006
- Modulation of monocyte function by activated protein C, a natural anticoagulant.. Journal of Immunology. 177:2115-2122. 2006
- Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Journal of Experimental Medicine. 203:1447-1458. 2006
- Bone marrow-derived dendritic cell vaccination of dogs with naturally occurring melanoma by using human gp100 antigen.. Journal of Veterinary Internal Medicine. 19:56-63. 2005
- Patients with severe sepsis vary markedly in their ability to generate activated protein C.. Blood. 104:3958-3964. 2004
- Endogenous protein C activation in patients with severe sepsis.. Critical Care Medicine. 32:S214-S218. 2004
- A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation.. Journal of Thrombosis and Haemostasis. 1:662-670. 2003
- Molecular basis for the susceptibility of fibrin-bound thrombin to inactivation by heparin cofactor ii in the presence of dermatan sulfate but not heparin.. Journal of Biological Chemistry. 276:20959-20965. 2001
- Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.. Journal of Biological Chemistry. 276:8364-8370. 2001
- Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function.. Journal of Biological Chemistry. 275:5447-5452. 2000
- Comparison of heparin- and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin cofactor II.. Journal of Biological Chemistry. 274:27597-27604. 1999
- Characterization of the stress-inducing effects of homocysteine.. Biochemical Journal. 332 ( Pt 1):213-221. 1998
- Localization of the thrombin-binding domain on prothrombin fragment 2.. Journal of Biological Chemistry. 273:8932-8939. 1998
- Visual detection method for identifying recombinant bacterial colonies.. BioTechniques. 18:380-384. 1995
- Defining the sequence specificity of the Saccharomyces cerevisiae DNA binding protein REB1p by selecting binding sites from random-sequence oligonucleotides.. Yeast. 10:771-787. 1994
- TATA-binding protein activates transcription when upstream of a GCN4-binding site in a novel yeast promoter.. Journal of Biological Chemistry. 267:20943-20952. 1992
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conference paper
- Biological Rational for the Use of Heparin in Septic Shock: Translational Data from the Halo Pilot RCT. Blood. 2015
- Cell-Free DNA modulates clot structure and impairs fibrinolysis in sepsis. Journal of Thrombosis and Haemostasis. 341-341. 2015
- Impact of PCSK9 in a murine mouse model of sepsis. Journal of Thrombosis and Haemostasis. 379-379. 2015
- Impact of the endothelial protein C receptor in coagulation, inflammation and hematopoiesis. Journal of Thrombosis and Haemostasis. 75-75. 2015
- Procoagulant effects of lung cancer chemotherapy through release of microparticles and cell-free DNA. Journal of Thrombosis and Haemostasis. 309-309. 2015
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells. Journal of Thrombosis and Haemostasis. 724-724. 2011
- Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes.. Journal of Thrombosis and Haemostasis. 619-626. 2009