selected scholarly activity
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academic article
- Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis. Lab on a Chip - Miniaturisation for Chemistry and Biology. 22:2566-2577. 2022
- Investigations of the effectiveness of heparin variants as inhibitors of histones. Journal of Thrombosis and Haemostasis. 20:1485-1495. 2022
- Single-step measurement of cell-free DNA for sepsis prognosis using a thread-based microfluidic device. Mikrochimica Acta. 189:146. 2022
- Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging. Circulation Research. 130:252-272. 2022
- Mechanistic Studies of DNase I Activity: Impact of Heparin Variants and PAD4. Shock. 56:975-987. 2021
- National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Medicine Experimental. 9:14. 2021
- Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: A single‐center prospective longitudinal study. Journal of Thrombosis and Haemostasis. 19:1546-1557. 2021
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators, B: Chemical. 330:129265-129265. 2021
- Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients. PLoS ONE. 16:e0247017-e0247017. 2021
- Hypercoagulability and coronavirus disease 2019–associated hypoxemic respiratory failure: Mechanisms and emerging management paradigms. Journal of Trauma. 89:e177-e181. 2020
- Identification of hemostatic markers that define the pre‐DIC state: A multi‐center observational study. Journal of Thrombosis and Haemostasis. 18:2524-2531. 2020
- Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Canadian Journal of Anaesthesia. 67:475-484. 2020
- Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism?. Thrombosis Research. 186:13-19. 2020
- Epigenetic Profiling in Severe Sepsis. Critical Care Medicine. 48:142-150. 2020
- Comparison of the source and prognostic utility of cfDNA in trauma and sepsis. Intensive Care Medicine Experimental. 7:29. 2019
- Purification of silica‐free DNA and characterization of its role in coagulation. Journal of Thrombosis and Haemostasis. 17:1860-1865. 2019
- <p>Modulation of Human Neutrophil Peptides on <em>P. aeruginosa</em> Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles</p>. Journal of Inflammation Research. Volume 12:335-343. 2019
- Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis. Intensive Care Medicine Experimental. 6:20. 2018
- Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8:10496. 2018
- Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. Critical Care Medicine. 46:e921-e927. 2018
- Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism. Blood. 131:2151-2160. 2018
- Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia. Critical Care Critical Care. 21:97. 2017
- Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis. Intensive Care Medicine Experimental. 5:5. 2017
- DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. American Journal of Respiratory and Critical Care Medicine. 195:889-905. 2017
- The impact of the endothelial protein C receptor on thrombin generation and clot lysis. Thrombosis Research. 152:30-37. 2017
- Procoagulant effects of lung cancer chemotherapy. Blood Coagulation and Fibrinolysis. 28:72-82. 2017
- A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Current Controlled Trials in Cardiovascular Medicine Trials. 17:556. 2016
- Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis. Shock. 46:672-680. 2016
- Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes. Shock. 46:655-662. 2016
- Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis. Journal of Thrombosis and Haemostasis. 14:2274-2286. 2016
- D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment. Thrombosis Research. 146:119-125. 2016
- Quantification of Cell-Free DNA in Red Blood Cell Units in Different Whole Blood Processing Methods. Journal of Blood Transfusion Journal of Blood Transfusion. 2016:1-5. 2016
- The role of leukocytes in thrombosis. Blood. 128:753-762. 2016
- DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC. Blood Reviews. 30:257-261. 2016
- Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin. Journal of Cellular and Molecular Medicine. 20:710-720. 2016
- Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells. Journal of Thrombosis and Haemostasis. 14:366-374. 2016
- Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology. 35:2544-2553. 2015
- Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro. Critical Care Critical Care. 19:149. 2015
- Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome. Arthritis and Rheumatology. 67:2990-3003. 2015
- A microfluidic device for rapid quantification of cell-free DNA in patients with severe sepsis. Lab on a Chip - Miniaturisation for Chemistry and Biology. 15:3925-3933. 2015
- Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA. Shock. 44:265-271. 2015
- Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis. Shock. 44:166-172. 2015
- Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis. Blood. 126:673-682. 2015
- Extracellular DNA and histones: double-edged swords in immunothrombosis. Journal of Thrombosis and Haemostasis. 13:S82-S91. 2015
- Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption. Blood Coagulation and Fibrinolysis. 26:36-45. 2015
- Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor. Thrombosis Research. 134:1142-1149. 2014
- Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms. Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1977-1984. 2014
- The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand. BMC Biochemistry. 14:6. 2013
- Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2674-2681. 2013
- Dalteparin Low Molecular Weight Heparin (LMWH) in ovarian cancer: A phase II randomized study. Thrombosis Research. 130:894-900. 2012
- Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Critical Care Critical Care. 16:R151-R151. 2012
- Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis. Journal of Critical Care. 26:556-565. 2011
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells. Journal of Thrombosis and Haemostasis. 9:2424-2435. 2011
- Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus. Journal of Thrombosis and Haemostasis. 9:2313-2321. 2011
- Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*. Critical Care Medicine. 39:702-710. 2011
- The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models. Journal of Thrombosis and Haemostasis. 9:767-775. 2011
- Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes. Journal of Thrombosis and Haemostasis. 9:582-592. 2011
- Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients. Pathophysiology of Haemostasis and Thrombosis Haemostasis. 37:88-97. 2010
- Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation. Journal of Heart and Lung Transplantation Journal of Heart Transplantation. 28:1180-1184. 2009
- Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes. Journal of Immunology. 181:2165-2173. 2008
- Protective effects of activated protein C in sepsis. Thrombosis and Haemostasis. 100:582-592. 2008
- Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma. Thrombosis Research. 122:418-426. 2008
- Hepatic leukocyte recruitment in response to time-limited expression of TNF-α and IL-1β. American Journal of Physiology - Gastrointestinal and Liver Physiology. 293:G663-G672. 2007
- Activated protein C in sepsis and beyond: Update 2006. Frontiers in Bioscience-Landmark. 12:1963-1963. 2007
- Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway. Molecular Cancer Therapeutics. 5:3303-3311. 2006
- Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant. Journal of Immunology. 177:2115-2122. 2006
- Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Journal of Experimental Medicine. 203:1447-1458. 2006
- Bone Marrow-Derived Dendritic Cell Vaccination of Dogs with Naturally Occurring Melanoma by Using Human gp100 Antigen. Journal of Veterinary Internal Medicine. 19:56-63. 2005
- Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood. 104:3958-3964. 2004
- Endogenous protein C activation in patients with severe sepsis. Critical Care Medicine. 32:S214-S218. 2004
- A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. Journal of Thrombosis and Haemostasis. 1:662-670. 2003
- Molecular Basis for the Susceptibility of Fibrin-bound Thrombin to Inactivation by Heparin Cofactor II in the Presence of Dermatan Sulfate but Not Heparin. Journal of Biological Chemistry. 276:20959-20965. 2001
- Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor. Journal of Biological Chemistry. 276:8364-8370. 2001
- A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function. Thrombosis and Haemostasis. 86:945-948. 2001
- Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function. Journal of Biological Chemistry. 275:5447-5452. 2000
- Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II. Journal of Biological Chemistry. 274:27597-27604. 1999
- Characterization of the stress-inducing effects of homocysteine. Biochemical Journal. 332:213-221. 1998
- Localization of the Thrombin-binding Domain on Prothrombin Fragment 2. Journal of Biological Chemistry. 273:8932-8939. 1998
- Visual detection method for identifying recombinant bacterial colonies.. BioTechniques. 18:380-384. 1995
- Defining the sequence specificity of theSaccharomyces cerevisiae DNA binding protein REB1p by selecting binding sites from random-sequence oligonucleotides. Yeast. 10:771-787. 1994
- TATA-binding protein activates transcription when upstream of a GCN4-binding site in a novel yeast promoter.. Journal of Biological Chemistry. 267:20943-20952. 1992
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chapter
- Coagulation Overview. 543-553. 2006
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conference paper
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators, B: Chemical. 2021
- Biological Rational for the Use of Heparin in Septic Shock: Translational Data from the Halo Pilot RCT. Blood. 2336-2336. 2015
- Cell-Free DNA modulates clot structure and impairs fibrinolysis in sepsis. Journal of Thrombosis and Haemostasis. 341-341. 2015
- Impact of PCSK9 in a murine mouse model of sepsis. Journal of Thrombosis and Haemostasis. 379-379. 2015
- Impact of the endothelial protein C receptor in coagulation, inflammation and hematopoiesis. Journal of Thrombosis and Haemostasis. 75-75. 2015
- Procoagulant effects of lung cancer chemotherapy through release of microparticles and cell-free DNA. Journal of Thrombosis and Haemostasis. 309-309. 2015
- Microfluidic device for clinical outcome prediction of severe sepsis. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 1036-1038. 2014
- Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells. Journal of Thrombosis and Haemostasis. 724-724. 2011
- Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes. Journal of Thrombosis and Haemostasis. 619-626. 2009