Journal article
Mechanistic Studies of DNase I Activity: Impact of Heparin Variants and PAD4
Abstract
Background: Excessive production of neutrophil extracellular traps (NETs) in sepsis contributes to vascular occlusion by acting as a scaffold and stimulus for thrombus formation. Removal of extracellular DNA, the major structural component of NETs, by DNase I may reduce host injury.
Objectives: (1) To determine how heparin variants (unfractionated heparin, enoxaparin, Vasoflux, and fondaparinux) affect DNase I activity,
Authors
Sohrabipour S; Muniz VS; Sharma N; Dwivedi DJ; Liaw PC
Journal
Shock, Vol. 56, No. 6, pp. 975–987
Publisher
Wolters Kluwer
Publication Date
December 2021
DOI
10.1097/shk.0000000000001804
ISSN
1073-2322