Journal article
Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol
Abstract
BackgroundThe importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational studies suffer from the effect of confounding factors. The controlled experimental environment afforded by preclinical studies allows for clarification and mechanistic evaluation of sex-dependent differences. …
Authors
Zhang M; Fergusson DA; Sharma R; Khoo C; Mendelson AA; McDonald B; Macala KF; Sharma N; Gill SE; Fiest KM
Journal
Systematic Reviews, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13643-023-02189-2
ISSN
2046-4053