Journal article
DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis
Abstract
RATIONALE: Effective and rapid bacterial clearance is a fundamental determinant of outcomes in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger.
OBJECTIVES: Because cellular ROS status is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sepsis.
Authors
Amatullah H; Shan Y; Beauchamp BL; Gali PL; Gupta S; Maron-Gutierrez T; Speck ER; Fox-Robichaud AE; Tsang JLY; Mei SHJ
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 7, pp. 889–905
Publisher
American Thoracic Society
Publication Date
April 1, 2017
DOI
10.1164/rccm.201604-0730oc
ISSN
1073-449X