Journal article
The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis
Abstract
Preclinical studies provide an opportunity to evaluate the relationship between sex and sepsis, and investigate underlying mechanisms in a controlled experimental environment. The objective of our systematic review was to assess the impact of biological sex on treatment response to fluid and antibiotic therapy in animal models of sepsis. Furthermore, we provide a narrative elaboration of sex-dependent differences in preclinical models of …
Authors
Zhang M; Montroy J; Sharma R; Fergusson DA; Mendelson AA; Macala KF; Bourque SL; Schlechte JM; Eng MK; McDonald B
Journal
Critical Care Explorations, Vol. 3, No. 6,
Publisher
Wolters Kluwer
DOI
10.1097/cce.0000000000000433
ISSN
2639-8028