selected scholarly activity
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chapters
- Biomarkers for coronary artery disease and heart failure. 519-543. 2020
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conferences
- High-sensitivity troponin I predicts major cardiovascular events after noncardiac surgery. European Heart Journal. 1675-1675. 2020
- ASSOCIATION BETWEEN HIGH-SENSITIVITY TROPONIN I AND MAJOR CARDIOVASCULAR EVENTS AFTER NON-CARDIAC SURGERY. Journal of the American College of Cardiology. 110-110. 2020
- Kinetics of High-Sensitivity Cardiac Troponin I and T Following Symptom Onset in Non-ST-Segment Elevation Myocardial Infarction: It is Time to Revise the Textbooks. Circulation. 2019
- The PROTROPIC feasibility study: prognostic value of elevated troponins in critical illness. Canadian Journal of Anaesthesia. 648-657. 2019
- Reducing Unnecessary Blood Tests in the Critically Ill (RUBIC): A Multi-Center Prospective Audit. American Journal of Respiratory and Critical Care Medicine. 2019
- Assessment of myocardial injury early after initiation of treatment in breast cancer patients using the Beckman Coulter and Abbott Diagnostics high-sensitivity cardiac troponin I tests. Clinical Biochemistry. 56-57. 2018
- Comparison of NT-pro BNP and BNP commercially-available assays. Clinical Biochemistry. 58-58. 2018
- Does Modern Mediastinal Irradiation Cause Acute Subclinical Cardiac Toxicity? The Final Results of the MEDICATE Study (Mediastinal Irradiation and Cardio-Toxic Effects). International Journal of Radiation Oncology Biology Physics. S88-S89. 2018
- High-Sensitivity Cardiac Troponin I at Presentation in Patients With Suspected Acute Coronary Syndrome. Circulation. 2017
- Pre-analytical storage conditions may affect Abbott ARCHITECT high-sensitivity cardiac troponin I results. Clinical Biochemistry. 2016
- OCOG-ALMERA: A phase II trial investigating the ability of metformin to chemo-radio-sensitize and prevent recurrence in locally advanced (LA) non-small cell lung cancer (NSCLC)∗. Journal of Thoracic Oncology. S50-S51. 2016
- Changes in glucose concentrations in emergency department patients presenting with symptoms of acute coronary syndrome. Clinical Biochemistry. 1021-1021. 2015
- Effect of glucose interference with Jaffe creatinine measurement on EGFR calculation. Clinical Biochemistry. 1019-1019. 2015
- Glucose interference in Jaffe Creatinine assays: Not all assays are the same. Clinical Biochemistry. 1008-1008. 2015
- Abstract 1154: Serum and urine markers of metabolic dysfunction in colorectal cancer: A pilot study. Cancer Research. 1154-1154. 2015
- An evaluation of the incidence and prognosis of post coronary artery bypass grafting myocardial infarction according to different definitions in the CORONARY trial. European Heart Journal. 360-360. 2015
- An event driven myocardial infarction definition using troponins after coronary artery bypass surgery in the coronary trial. European Heart Journal. 997-997. 2015
- Blood and urine markers of metabolic dysfunction in colorectal cancer: a pilot study.. Journal of Clinical Oncology. e14611-e14611. 2015
- Assessing the long-term stability of total bilirubin protected from light under refrigerated conditions. Clinical Biochemistry. 1151-1151. 2014
- Assessment of galectin-3, N-terminal pro-brain natriuretic peptide and inflammatory cytokines in patients with myocardial injury after initiation of adjuvant trastuzumab therapy. Clinical Biochemistry. 1144-1144. 2014
- Establishment of pediatric reference intervals for galectin-3 on the Abbott ARCHITECT using healthy community children from the CALIPER study. Clinical Biochemistry. 1155-1155. 2014
- Prevalence of known and unknown diabetes in emergency department patients presenting with symptoms of acute coronary syndrome. Clinical Biochemistry. 1156-1156. 2014
- The utility of galectin-3 and high-sensitivity cardiac troponin assays to predict short-term serious outcomes in patients presenting early after chest-pain onset. Clinical Biochemistry. 1151-1151. 2014
- A randomized phase II study of cediranib (CED) alone versus CED plus dasatinib (DAS) in patients (pts) with castration-resistant prostate cancer (CRPC).. Journal of Clinical Oncology. 5039-5039. 2013
- A randomized phase II study of cediranib (CED) alone versus CED plus dasatinib (DAS) in patients (pts) with castration-resistant prostate cancer (CRPC).. Journal of Clinical Oncology. 2013
- A biomarker panel for early identification of cardiac outcomes in a non-selected emergency department chest pain population. Clinical Biochemistry. 1115-1115. 2012
- Assessing different population-based troponin T 99th percentiles for women in labor. Clinical Biochemistry. 1113-1114. 2012
- Cardiac troponin T concentrations 30days post myocardial infarction: Results of a small prospective observational study. Clinical Biochemistry. 1119-1119. 2012
- Early serial measurements of myeloperoxidase, a sensitive cardiac troponin I and high-sensitivity cardiac troponin T in patients presenting within 6hours of chest pain onset. Clinical Biochemistry. 1111-1111. 2012
- Fatty acid binding protein and cardiac troponin I for the early rule-out of myocardial infarction in patients presenting with chest pain. Clinical Biochemistry. 1119-1119. 2012
- High sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in healthy Canadian children. Clinical Biochemistry. 1121-1122. 2012
- Incorporating both absolute and relative change in high-sensitivity cardiac troponin T concentrations for an early diagnosis of myocardial infarction. Clinical Biochemistry. 1122-1122. 2012
- OT1-02-13: Cardiac Biomarkers on Trastuzumab (Cabot Trial): Determining the Cardiac Biomarker Profile in Breast Cancer Patients Receiving Adjuvant Trastuzumab Therapy.. Cancer Research. 2011
- A clinically sensitive cardiac troponin I assay (AccuTnI) versus the high sensitive cardiac troponin T assay to predict early serious cardiac outcomes in patients with potential acute coronary syndrome. Clinical Biochemistry. 1174-1174. 2011
- A comparison between the different versions of the Beckman coulter cardiac troponin I assay. Clinical Biochemistry. 1177-1177. 2011
- An approach for comparability testing of 20 core clinical chemistry analytes measured between identical Roche P-modular platforms. Clinical Biochemistry. 1175-1176. 2011
- Comparison of angiogenic growth factors assays using a research mulitplex platform versus clinical platforms in patients with chest pain. Clinical Biochemistry. 1181-1182. 2011
- Comparison of cytokine biomarker performance across immunoassay platforms. Clinical Biochemistry. 1179-1179. 2011
- NT-proBNP measurement using a multiplex platform in cancer and chest pain populations. Clinical Biochemistry. 1172-1172. 2011
- Root cause analysis of delays to discharge for patients held for serial cardiac troponin levels. Clinical Biochemistry. 1176-1176. 2011
- The prevalence of preoperative elevations in troponin T above the 99th percentile using the troponin T high sensitive assay in patients undergoing noncardiac surgery. Clinical Biochemistry. 1174-1174. 2011
- Time from urine collection to urinalysis – Is four hours an acceptable delay for samples at room temperature?. Clinical Biochemistry. 1183-1183. 2011
- Assessing analytical variation and the significant change limit for total CO2 measurement in uncapped tubes. Clinical Biochemistry. 782-782. 2010
- Early changes in biomarkers determined by LC/MS/MS and ELISA based methods in a phase I/II study assessing an anti-metastatic agent. Clinical Biochemistry. 781-782. 2010
- Early detection of change in concentration by a research high sensitivity troponin I (hs-cTNI) assay and health outcomes at 30days in a chest pain population. Clinical Biochemistry. 782-782. 2010
- Factors affecting screen completion in two forms of integrated prenatal screening for Down syndrome in the safer study. Clinical Biochemistry. 783-783. 2010
- Roche acetaminophen assay negative bias at low concentrations is imprvoved using the TDM diluent as the zero calibrator. Clinical Biochemistry. 782-782. 2010
- A Multimarker approach for the prediction of evolving myocardial injury in women presenting with symptoms suggestive of acute coronary syndromes. Clinical Chemistry. A64-A64. 2009
- A biomarker panel for identification of acute coronary syndrome patients at risk for subsequent heart failure/death. Clinical Chemistry. A52-A52. 2009
- A mass spectrometry approach to identify surrogate biomarkers; for early responders to an anti-metastatic/anti-tumor investigational agent. Clinical Chemistry. A114-A115. 2009
- Cytokines and cell adhesion molecules exhibit cancer specific profiles in patients with metastatic disease treated with an investigational anti-metastatic agent. Clinical Chemistry. A116-A117. 2009
- Impact of "change criteria" and a novel high sensitivity cardiac troponin I assay in predicting health outcomes. Clinical Chemistry. A52-A52. 2009
- Long-term survival is predicted in patients presenting with chest pain by PAPP-A measurements. Clinical Chemistry. A52-A52. 2009
- 112 POSTER A clinical chemistry approach for identifying biomarkers as surrogate endpoints in therapy directed against chemokine mediated metastasis. European Journal of Cancer, Supplement. 37-37. 2008
- Assessment of the use of the 99th percentile cut-off for myocardial injury on the Abbott Architect STAT Troponin-I assay. Clinical Biochemistry. 1270-1270. 2008
- Pilot study assessing the utility of an adhesion array and high-sensitivity cytokine array as surrogate biomarkers in ovarian cancer. Clinical Biochemistry. 1271-1271. 2008
- Sex differences in pregnancy associated plasma protein-A (PAPP-A) concentrations in patients with acute coronary syndromes. Clinical Biochemistry. 1271-1272. 2008
- Evaluation of a high sensitivity cardiac troponin I assay in an Acute Coronary Syndrome population. Clinical Chemistry. A92-A92. 2008
- Preliminary investigation of a high sensitivity PAPP-A research assay in an Acute Coronary Syndrome population. Clinical Chemistry. A92-A92. 2008
- Assessment of the validity of self-reported versus quantitative measures for population and public health planning. Clinical Biochemistry. 194-194. 2008
- Cardiovascular risk identification in population health by biological measures. Clinical Biochemistry. 194-194. 2008
- Stability of therapeutic drugs in heparin plasma with and without gel seperator. Clinical Biochemistry. 181-181. 2008
- Time-related profile of cell adhesion molecules, NT-proBNP and troponin T following chest pain onset in an emergency department population. Clinical Biochemistry. 193-193. 2008
- Uptake and overall performance of multiple new down syndrome screening protocols introduced coincidentally. Clinical Biochemistry. 195-195. 2008
- Early detection of rising patterns of troponin I, T and NT-proBNP in a chest pain emergency department cohort. Clinical Chemistry. A21-A21. 2007
- Serial cytokine profile in an emergency department chest pain population. Clinical Chemistry. A16-A16. 2007
- Comparing the World Health Organization MONICA definition for Acute Myocardial Infarction versus the ESC/ACC definition in identifying chest pain patients at increased risks. Clinical Chemistry. A16-A17. 2006
- A short-interval specimen collection protocol with early accurate detection of acute myocardial infarction using the sensitive AccuTnI biomarker. Clinical Chemistry. A23-A23. 2005
- An evaluation of a new blood test for TB (M-tuberculosis) detection in patients receiving BCG (Bacillus Calmette-Guerin) therapy. Clinical Chemistry. A175-A176. 2005
- Assessing the requirement for the six-hour interval between specimens in the American Heart Association case definition for AMI, using a highly sensitive troponin assay. Clinical Chemistry. A22-A23. 2005
- Biomarker case study applying the 2003 AHA case definition for AMI in epidemiology and clinical research studies with the AccuTnI marker. Clinical Chemistry. A22-A22. 2005
- Performance of CKMB isoforms in a population defined by the 2003 American Heart Association case definition for acute coronary heart disease. Clinical Chemistry. A22-A22. 2005
- Clinical evaluation of the Beckman Coulter AccuTnI assay for the early detection of acute myocardial infarction. Clinical Chemistry. A5-A5. 2004
- Impact of the evolving definition of myocardial infarction and the improved analytical sensitivity of troponin measurement on the frequency of diagnosis. Clinical Chemistry. A7-A7. 2004
- Ubiquitination regulates BMP signaling and embryonic pattern formation in Xenopus.. Developmental Biology. 206-206. 1999
- A national study to evaluate analytical performance specifications for high-sensitivity cardiac troponin assays. Clinical Biochemistry. 109-109.
- Analytical validation of the Thermo Fischer Scientific B center dot R center dot A center dot H center dot M center dot S KRYPTOR (R) soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) assays in a North American setting. Clinical Biochemistry. 113-114.
- Multisite evaluation of high-sensitivity cardiac Troponin T with patient pools on different Roche analyzers: Interim report on observed components of variance. Clinical Biochemistry. 109-110.
- Multisite testing with different high-sensitivity cardiac troponin I assays in the normal range and near the 99th percentiles. Clinical Biochemistry. 108-109.
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journal articles
- The clinical chemistry score (CCS) achieves the highest efficacy when assessed with the 99% sensitivity benchmark for myocardial infarction. International Journal of Cardiology. 403:131898-131898. 2024
- Enquête canadienne sur les perceptions et pratiques liées à la prescription de tests sanguins aux soins intensifs. Canadian Journal of Anaesthesia. 2024
- Discordant High-Sensitivity Cardiac Troponin I Concentrations in the General Population. Clinical Chemistry. 70:562-564. 2024
- High-Sensitivity Cardiac Troponin and the Management of Congenital Heart Disease in Newborns and Infants. Clinical Chemistry. 70:486-496. 2024
- Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile. Clinical Biochemistry. 125:110731-110731. 2024
- The Role of Artificial Intelligence for Providing Scientific Content for Laboratory Medicine. The journal of applied laboratory medicine. 9:386-393. 2024
- High-Sensitivity Cardiac Troponin I for Long-Term Cardiovascular Risk Stratification in a Cancer Clinic Population. JACC: CardioOncology. 6:136-138. 2024
- ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation. European Journal of Anaesthesiology, Supplement. 40:888-927. 2023
- Cardiac troponin testing in cardiac surgery. Expert Review of Cardiovascular Therapy. 21:729-731. 2023
- Trends in B-Type Natriuretic Peptide Testing. JACC: Heart Failure. 11:1645-1647. 2023
- Establishing acceptable variation between instruments with dry chemistry methodology. Clinical Biochemistry. 120:110647-110647. 2023
- Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology. 112:1288-1301. 2023
- Impact of switching total bilirubin assays on the classification of neonates at high risk for hyperbilirubinemia. Clinical Chemistry and Laboratory Medicine. 61:e175-e178. 2023
- The Clinical Validation of a Common Analytical Change Criteria for Cardiac Troponin for Ruling in an Acute Cardiovascular Outcome in Patients Presenting with Ischemic Chest Pain Symptoms. Journal of Cardiovascular Development and Disease. 10:335-335. 2023
- An interference yielding divergent high-sensitivity cardiac troponin results on different instruments from the same manufacturer. Clinica Chimica Acta. 548:117450-117450. 2023
- Detection of Macrotroponin in Patients Receiving Treatment for Breast Cancer. CJC OPEN. 5:658-660. 2023
- Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers. Clinical Chemistry and Laboratory Medicine. 61:1411-1419. 2023
- Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences. Canadian Journal of Cardiology. 39:947-951. 2023
- Troponin T Levels and When to Peek Using CMR in Patients With MINOCA. Canadian Journal of Cardiology. 39:945-946. 2023
- Individual risk prediction of high grade prostate cancer based on the combination between total prostate-specific antigen (PSA) and free to total PSA ratio. Clinical Chemistry and Laboratory Medicine. 61:1327-1334. 2023
- Lot-to-lot bias for high-sensitivity cardiac troponin I concentrations ≥1000 ng/L. Clinical Chemistry and Laboratory Medicine. 61:e105-e107. 2023
- Reference intervals for thyroid biomarkers to enhance the assessment of thyroid status in childhood and adolescence. Clinical Chemistry and Laboratory Medicine. 61:1309-1318. 2023
- Using logistic regression models to investigate the effects of high-sensitivity cardiac troponin T confounders on ruling in acute myocardial infarction. Clinical Chemistry and Laboratory Medicine. 61:1335-1342. 2023
- Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB). Clinical Chemistry and Laboratory Medicine. 61:989-998. 2023
- Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery. Anesthesiology. 138:508-522. 2023
- Storage conditions, sample integrity, interferences, and a decision tool for investigating unusual high-sensitivity cardiac troponin results. Clinical Biochemistry. 115:67-76. 2023
- High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy. Clinical Chemistry. 69:492-499. 2023
- Identifying Very-Low-Risk Patients for Future Myocardial Infarction or Death. Canadian Journal of Cardiology. 39:527-530. 2023
- 30-DAY AND 1-YEAR MORTALITY IN A 4-YEAR POPULATION-BASED COHORT: ASSOCIATIONS WITH NATRIURETIC PEPTIDE TYPE AND PREVIOUS HEART FAILURE DIAGNOSIS. Journal of the American College of Cardiology. 81:651-651. 2023
- High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study. Canadian Journal of Cardiology. 39:311-318. 2023
- High-Sensitivity Cardiac Troponin Publications during the COVID-19 Pandemic (2020–2022). Journal of Cardiovascular Development and Disease. 10:5-5. 2022
- Discrepant high-sensitivity cardiac troponin I concentrations when measured on the Abbott Alinity ci versus the Abbott Architect system. Clinica Chimica Acta. 537:105-106. 2022
- Incidence and Etiology of Poor Duplicate Ortho High-Sensitivity Cardiac Troponin I Results in a Community Hospital Emergency Department. CJC OPEN. 4:1100-1101. 2022
- The PROVE-HF Study: Additional Proof for the Inclusion of the Manufacturer’s Name When Reporting B-Type Natriuretic Peptide Results. Clinical Chemistry. 68:1353-1355. 2022
- Presence of Macrotroponin for Over 2 Years in a Young Woman. CJC OPEN. 4:1012-1014. 2022
- Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial. Journal of Experimental and Clinical Cancer Research. 41:255. 2022
- Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. Clinical Chemistry. 68:1022-1030. 2022
- Commentary on Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection. Clinical Chemistry. 68:1019-1020. 2022
- The Need to Develop Clinical Guidance for the Use of High-Sensitivity Cardiac Troponin in Pediatric and Neonatal Patients. Clinical Chemistry. 68:884-886. 2022
- High-sensitivity cardiac troponin and the importance of cutoffs in patients with prior coronary artery bypass grafting with suspected NSTEMI. International Journal of Cardiology. 356:36-37. 2022
- Imprecision and Delta Criteria for a New ESC 0/2-Hour Algorithm. Clinical Chemistry. 68:721-722. 2022
- M173 Total imprecision of 8 high sensitivity cardiac troponin assays within sex-specific reference limits: Clinical implications. Clinica Chimica Acta. 530:S282-S282. 2022
- Sex-Specific Absolute Delta Thresholds for High-Sensitivity Cardiac Troponin T. Clinical Chemistry. 68:441-449. 2022
- High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality. New England Journal of Medicine. 386:827-836. 2022
- Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination. Clinical Biochemistry. 101:54-55. 2022
- PATTERNS OF NATRIURETIC PEPTIDE ADOPTION IN ONTARIO, CANADA: A POPULATION-BASED ANALYSIS. Journal of the American College of Cardiology. 79:435-435. 2022
- Measurement in different sample types may aid in detecting interferences and macrocomplexes affecting cardiac troponin measurements. Clinical Chemistry and Laboratory Medicine. 60:66-67. 2022
- Performance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction. ACP journal club. 175:101-113. 2022
- The imprecision for a high-sensitivity cardiac troponin assay and a CA 19-9 assay in samples with high C-reactive protein concentrations. Clinica Chimica Acta. 524:192-193. 2022
- Biomarker Testing Considerations in the Evaluation and Management of Patients With Heart Failure: Perspectives From the International Federation of Clinical Chemistry and Laboratory Medicine Committee. Journal of Cardiac Failure. 27:1456-1461. 2021
- Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US population. Clinica Chimica Acta. 523:397-401. 2021
- Low-risk cutoff of 90 ml/min/1.73 m2 for the estimated glomerular filtration rate and the importance of the equation for patients with acute coronary syndrome. Clinica Chimica Acta. 523:532-533. 2021
- Repeat measurements on patient samples identifies unpredictable and poorly reproducible cardiac troponin results with a high-sensitivity cardiac troponin assay. Annals of Clinical Biochemistry. 58:677-679. 2021
- Single troponin to rule-out MI in early presenters, perhaps, but not major adverse cardiac events. International Journal of Cardiology. 342:29-30. 2021
- Can the Addition of NT-proBNP and Glucose Measurements Improve the Prognostication of High-Sensitivity Cardiac Troponin Measurements for Patients with Suspected Acute Coronary Syndrome?. Journal of Cardiovascular Development and Disease. 8:106-106. 2021
- Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population. Clinical Biochemistry. 95:91-92. 2021
- Letter by Hwang et al Regarding Article, “Temporal Release of High-Sensitivity Cardiac Troponin T and I and Copeptin After Brief Induced Coronary Artery Balloon Occlusion in Humans”. Circulation. 144:e166-e167. 2021
- Diagnostic Performance of Serial High-Sensitivity Cardiac Troponin Measurements in the Emergency Setting. Journal of Cardiovascular Development and Disease. 8:97-97. 2021
- A Large Number of Fresh Samples and a Wide Range of Total Prostate-Specific Antigen (tPSA) Concentrations Is Important to Detect Differences in PSA Methods. Clinical Chemistry. 67:1155-1157. 2021
- An Approach to Investigating Discordant High-Sensitivity Cardiac Troponin I Results. Canadian Journal of Cardiology. 37:1292-1293. 2021
- Combination of lymphocyte count and not the serological response with high-sensitivity cardiac troponin for risk stratification in patients with possible COVID-19. Clinica Chimica Acta. 519:306-307. 2021
- The effect of the Covid-19 shutdown on glycemic testing and control. Clinica Chimica Acta. 519:148-152. 2021
- Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays. Clinical Chemistry and Laboratory Medicine. 59:1431-1443. 2021
- Side-Effects of COVID-19 on Patient Care: An INR Story. The journal of applied laboratory medicine. 6:953-961. 2021
- Additional approaches for identifying non-reproducible cardiac troponin results. Clinical Chemistry and Laboratory Medicine. 59:e267-e270. 2021
- Effect of racing on cardiac troponin I concentration and associations with cardiac rhythm disturbances in Standardbred racehorses. Journal of Veterinary Cardiology. 35:14-24. 2021
- Important Differences Between Manufacturers When Transitioning From a Contemporary Cardiac Troponin Assay to a High-Sensitivity Cardiac Troponin Assay. CJC OPEN. 3:841-842. 2021
- Getting Cardiac Troponin Right: Appraisal of the 2020 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation by the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Applications of Cardiac Bio-Markers. Clinical Chemistry. 67:730-735. 2021
- Analytical assessment of ortho clinical diagnostics high-sensitivity cardiac troponin I assay. Clinical Chemistry and Laboratory Medicine. 59:749-755. 2021
- Disagreement between Cardiac Troponin Tests Yielding a Higher Incidence of Myocardial Injury in the Emergency Setting. Journal of Cardiovascular Development and Disease. 8:31-31. 2021
- Acute Phase Response and Non-Reproducible Elevated Concentrations with a High-Sensitivity Cardiac Troponin I Assay. Journal of Clinical Medicine. 10:1014-1014. 2021
- Misclassification of Myocardial Injury by a High-Sensitivity Cardiac Troponin I Assay. Canadian Journal of Cardiology. 37:523.e7-523.e8. 2021
- Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results. Clinical Chemistry. 67:107-113. 2021
- Impact of Switching Sample Types for High-Sensitivity Cardiac Troponin I Assays in the 0/1 Hour Algorithms. Clinical Chemistry. 67:319-321. 2021
- Sex-Specific Kinetics of High-Sensitivity Cardiac Troponin I and T following Symptom Onset and Early Presentation in Non-ST-Segment Elevation Myocardial Infarction. Clinical Chemistry. 67:321-324. 2021
- Variability in Cardiac Biomarkers during Hemodialysis: A Prospective Cohort Study. Clinical Chemistry. 67:308-316. 2021
- Admission High-Sensitivity Cardiac Troponin vs a Biochemical Score for Predicting Mortality in Patients With COVID-19. CJC OPEN. 3:130-131. 2021
- Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study establishing diagnostic criteria and prognostic importance. British Journal of Anaesthesia. 126:163-171. 2021
- Preoperative prediction of Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study. British Journal of Anaesthesia. 126:172-180. 2021
- Canadian society of clinical chemists (CSCC) interim consensus guidance for testing and reporting of SARS-CoV-2 serology. Clinical Biochemistry. 86:1-7. 2020
- Comparison of two biomarker only algorithms for early risk stratification in patients with suspected acute coronary syndrome. International Journal of Cardiology. 319:140-143. 2020
- Detection of repeated positive result biases for a high-sensitivity cardiac troponin I assay. Clinica Chimica Acta. 510:242-243. 2020
- High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial. American Heart Journal. 229:18-28. 2020
- Analytical performance of cardiac troponin assays – Current status and future needs. Clinica Chimica Acta. 509:149-155. 2020
- Using the clinical chemistry score in the emergency department to detect adverse cardiac events: a diagnostic accuracy study. CMAJ open. 8:E676-E684. 2020
- Risk Stratification for Patients with Chest Pain Discharged Home from the Emergency Department. Journal of Clinical Medicine. 9:2948-2948. 2020
- 206: A Randomized Phase Ii Trial of Prostate Boost Irradiation with Stereotactic Body Radiotherapy (SBRT) in High-Risk Prostate Cancer. The Pbs Trial. Radiotherapy and Oncology. 150:S87-S88. 2020
- Commercial Quality Control Imprecision Estimates for High-Sensitivity Cardiac Troponin Deltas Used to Rule-in Myocardial Infarction with the ESC 0/1-Hour Algorithm. The journal of applied laboratory medicine. 5:1122-1124. 2020
- Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay’s Limit of Detection?. Clinical Chemistry. 66:1146-1149. 2020
- A Randomized Phase II Trial of Prostate Boost Irradiation With Stereotactic Body Radiotherapy (SBRT) or Conventional Fractionation (CF) External Beam Radiotherapy (EBRT) in Locally Advanced Prostate Cancer: The PBS Trial (NCT03380806). Clinical Genitourinary Cancer. 18:e410-e415. 2020
- Caution When Using High-Sensitivity Cardiac Troponin I Assay to Rule Out Acute Ischemia: When the Delta to Rule In Is Within Analytical Variation. Canadian Journal of Cardiology. 36:1161.e11-1161.e12. 2020
- Emerging key laboratory tests for patients with COVID-19. Clinical Biochemistry. 81:13-14. 2020
- High-Sensitivity Cardiac Troponin I vs a Clinical Chemistry Score for Predicting All-Cause Mortality in an Emergency Department Population. CJC OPEN. 2:296-302. 2020
- High-Sensitivity Cardiac Troponin T Testing and Cardiovascular Outcomes at 30 Days and 1 Year in Patients Discharged Home from the Emergency Department with Chest Pain. The journal of applied laboratory medicine. 5:821-824. 2020
- Quality Improvement High-Sensitivity Cardiac Troponin I vs a Clinical Chemistry Score for Predicting All-Cause Mortality in an Emergency Department Population. CJC OPEN. 2:296-302. 2020
- Clinical chemistry tests for patients with COVID-19 – important caveats for interpretation. Clinical Chemistry and Laboratory Medicine. 58:1142-1143. 2020
- A Three-Site Immunoassay for High-Sensitivity Cardiac Troponin I with Low Immunoreactivity for Macrocomplexes. Clinical Chemistry. 66:854-855. 2020
- Clinical evaluation of Ortho Clinical Diagnostics high-sensitivity cardiac Troponin I assay in patients with symptoms suggestive of acute coronary syndrome. Clinical Biochemistry. 80:48-51. 2020
- Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years. Clinica Chimica Acta. 505:6-8. 2020
- Approaching 2020 acuity for high-sensitivity cardiac troponin assays in Clinical Biochemistry. Clinical Biochemistry. 78:1-3. 2020
- Clinical outcomes for chest pain patients discharged home from emergency departments using high-sensitivity versus conventional cardiac troponin assays. American Heart Journal. 221:84-94. 2020
- Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery. American Heart Journal. 220:253-263. 2020
- Preoperative N-Terminal Pro–B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery. ACP journal club. 172:96-96. 2020
- Definitions of post-coronary artery bypass grafting myocardial infarction: variations in incidence and prognostic significance. European Journal of Cardio-thoracic Surgery. 57:168-175. 2020
- Analytical Variation and Abbott Diagnostics High-Sensitivity Cardiac Troponin I Risk Categories in Asymptomatic Individuals. Canadian Journal of Cardiology. 35:1605.e7-1605.e8. 2019
- High-sensitivity cardiac troponin testing during and after ACS: Complexed or not?. Clinical Biochemistry. 73:32-34. 2019
- High-sensitivity troponin testing months after an acute coronary syndrome: noise or notable results. Heart. 105:1688-1690. 2019
- Long-term quality control testing on a high-sensitivity cardiac troponin I assay. Clinica Chimica Acta. 498:27-29. 2019
- Measurement of High-Sensitivity Cardiac Troponin in Pulmonary Embolism: Useful Test or a Clinical Distraction. Seminars in Vascular Medicine. 45:784-792. 2019
- The importance of the methodology and sample matrix when interpreting chromogranin A results. Clinical Chemistry and Laboratory Medicine. 57:e291-e293. 2019
- Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC Committee on Clinical Applications of Cardiac Bio-Markers. Clinical Chemistry. 65:1221-1227. 2019
- Rapid atrophy of cardiac left ventricular mass in patients with non‐small cell carcinoma of the lung. Journal of Cachexia, Sarcopenia and Muscle. 10:1070-1082. 2019
- A Multicenter Assessment of the Sensitivity and Specificity for a Single High-Sensitivity Cardiac Troponin Test at Emergency Department Presentation for Hospital Admission. The journal of applied laboratory medicine. 4:170-179. 2019
- A heterophile antibody affecting a contemporary but not a high-sensitivity cardiac troponin assay. Clinical Biochemistry. 71:72-73. 2019
- A post-hoc subgroup analysis assessing acute cardiac biomarker profiles in female cancer patients during adjuvant therapy. Clinica Chimica Acta. 495:355-357. 2019
- Analytical characterization of the Siemens Dimension EXL high-sensitivity cardiac troponin I assay. Clinical Biochemistry. 69:52-56. 2019
- MEDiastinal Irradiation and CArdio-Toxic Effects (MEDICATE): Exploring the Relationship between Cardiac Irradiation and High Sensitivity Troponins. Clinical Oncology. 31:479-485. 2019
- Application of High-Sensitivity Troponin in Suspected Myocardial Infarction. New England Journal of Medicine. 380:2529-2540. 2019
- Effect of Storage Temperature for B-Type Natriuretic Peptide Concentrations for Primary Healthcare Populations. Clinical Chemistry. 65:811-812. 2019
- Four Different High-Sensitivity Cardiac Troponin Assays With Important Analytical Performance Differences. Canadian Journal of Cardiology. 35:796.e17-796.e18. 2019
- LO01: Development and validation of an adjustment score for ruling out MI using a single high-sensitivity cardiac troponin T assay in patients with chest pain and kidney dysfunction. Canadian Journal of Emergency Medicine. 21:S6-S7. 2019
- The Evidence for Laboratory Test–Based Computer Clinical Decision Support Tools on Medication Errors and Adverse Drug Events. The journal of applied laboratory medicine. 3:922-924. 2019
- Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB). Clinical Chemistry and Laboratory Medicine. 57:633-640. 2019
- Sample matrix and high-sensitivity cardiac troponin I assays. Clinical Chemistry and Laboratory Medicine. 57:745-751. 2019
- High-Sensitivity Generation 5 Cardiac Troponin T Sex- and Age-Specific 99th Percentiles in the CALIPER Cohort of Healthy Children and Adolescents. Clinical Chemistry. 65:589-591. 2019
- Longitudinal High-Sensitivity Cardiac Troponin I Measurements in Patients With Breast Cancer Receiving Trastuzumab. Canadian Journal of Cardiology. 35:545.e1-545.e2. 2019
- Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l. Clinica Chimica Acta. 489:58-60. 2019
- Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I. Clinical Biochemistry. 63:158-160. 2019
- Sex-specific, high-sensitivity cardiac troponin T cut-off concentrations for ruling out acute myocardial infarction with a single measurement. Canadian Journal of Emergency Medicine. 21:26-33. 2019
- Perioperative heart-type fatty acid binding protein concentration cutoffs for the identification of severe acute kidney injury in patients undergoing cardiac surgery. Clinical Chemistry and Laboratory Medicine. 57:e8-e10. 2018
- Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study. Biomarker Research. 6:3. 2018
- Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum. Clinica Chimica Acta. 487:216-221. 2018
- Multicenter comparison of imprecision at low concentrations of two regulatory approved high-sensitivity cardiac troponin I assays. Clinica Chimica Acta. 486:219-220. 2018
- The importance of tumour marker dual reporting during method transition: PSA high-dose hook effect detected. Clinical Biochemistry. 61:45-46. 2018
- Differences in total PSA results within and between manufacturers. Clinical Biochemistry. 60:91-92. 2018
- External Quality Assessment Testing Near the Limit of Detection for High-Sensitivity Cardiac Troponin Assays. Clinical Chemistry. 64:1402-1404. 2018
- High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome. Annals of Clinical Biochemistry. 55:604-607. 2018
- Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CANADIAN MEDICAL ASSOCIATION JOURNAL. 190:E974-E984. 2018
- The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations. Clinical Biochemistry. 58:53-59. 2018
- Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations. Annals of Clinical Biochemistry. 55:500-504. 2018
- Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays. Clinical Chemistry and Laboratory Medicine. 56:1176-1181. 2018
- Profile of Roche’s Elecsys Troponin T Gen 5 STAT blood test (a high-sensitivity cardiac troponin assay) for diagnosing myocardial infarction in the emergency department. Expert Review of Molecular Diagnostics. 18:481-489. 2018
- Should detectable cardiac troponin concentrations in a healthy population be the only criterion for classifying high-sensitivity cardiac troponin assays?. Clinical Biochemistry. 56:1-3. 2018
- LO61: Test characteristics of high sensitivity troponin T performed at emergency department arrival for acute myocardial infarction in patients with reduced kidney function. Canadian Journal of Emergency Medicine. 20:S28-S28. 2018
- P101: Sex-specific Troponin T cutoffs for ruling out acute myocardial infarction at ED arrival. Canadian Journal of Emergency Medicine. 20:S92-S92. 2018
- Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products. Critical Care Medicine. 46:e326-e329. 2018
- Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine. Clinical Chemistry. 64:645-655. 2018
- Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates. Clinica Chimica Acta. 479:166-170. 2018
- Analytical validation of cardiac troponin I assays in horses. Journal of Veterinary Diagnostic Investigation. 30:226-232. 2018
- Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay. Clinical Chemistry. 64:398-399. 2018
- Contemporary Emergency Department Management of Patients with Chest Pain: A Concise Review and Guide for the High-Sensitivity Troponin Era. Canadian Journal of Cardiology. 34:98-108. 2018
- Variability Between Reagent Lots for High-Sensitivity Cardiac Troponin I May Affect Performance of Early Rule Out Strategies. Canadian Journal of Cardiology. 34:209.e5-209.e6. 2018
- Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10 years. Clinica Chimica Acta. 475:51-55. 2017
- Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial. Clinical Biochemistry. 50:1104-1109. 2017
- Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery. Journal of the American Society of Nephrology. 28:3699-3707. 2017
- Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome. Journal of the American Medical Association (JAMA). 318:1913-1913. 2017
- THE PROTROPIC FEASIBILITY STUDY: PROGNOSTIC VALUE OF ELEVATED TROPONINS IN CRITICAL ILLNESS. Canadian Journal of Cardiology. 33:S56-S56. 2017
- Undetectable Concentrations of a Food and Drug Administration–approved High‐sensitivity Cardiac Troponin T Assay to Rule Out Acute Myocardial Infarction at Emergency Department Arrival. Academic Emergency Medicine. 24:1267-1277. 2017
- Variability and Error in Cardiac Troponin Testing. American Journal of Clinical Pathology. 148:281-295. 2017
- 4 hs-cTnI algorithms had high sensitivity and low failure rates for ruling out acute MI in the ED. ACP journal club. 167:JC35-JC35. 2017
- High-STEACS Algorithm missed fewer patients with acute MI than the ESC Pathway in the ED. ACP journal club. 167:JC34-JC34. 2017
- Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study. CMAJ open. 5:E594-E603. 2017
- Book Review. Clinical Biochemistry. 50:737-737. 2017
- Comparative Evaluation of 2-Hour Rapid Diagnostic Algorithms for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin T. Canadian Journal of Cardiology. 33:1006-1012. 2017
- Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. Annals of Thoracic Surgery. 104:613-620. 2017
- High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation. Canadian Journal of Cardiology. 33:898-903. 2017
- A laboratory score at presentation to rule-out serious cardiac outcomes or death in patients presenting with symptoms suggestive of acute coronary syndrome. Clinica Chimica Acta. 469:69-74. 2017
- Effect of Repeat Measurements of High-Sensitivity Cardiac Troponin on the Same Sample Using the European Society of Cardiology 0-Hour/1-Hour or 2-Hour Algorithms for Early Rule-Out and Rule-In for Myocardial Infarction. Clinical Chemistry. 63:1163-1165. 2017
- Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay. Clinical Chemistry. 63:1043-1045. 2017
- Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. Journal of the American Medical Association (JAMA). 317:1642-1642. 2017
- Response by Than et al to Letter Regarding Article, “Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction”. Circulation. 135:e923-e924. 2017
- Left Atrial Function During the First Year After Pediatric Heart Transplantation. The Journal of Heart and Lung Transplantation. 36:S104-S105. 2017
- Stressing the Utility of High-Sensitivity Cardiac Troponin Testing in Patients with Possible Cardiac Ischemia. The journal of applied laboratory medicine. 1:468-470. 2017
- Commutable samples with assigned target concentrations may help us harmonise general chemistry results. Clinical Chemistry and Laboratory Medicine. 55:165-166. 2017
- Economic Considerations of Early Rule-In/Rule-Out Algorithms for The Diagnosis of Myocardial Infarction in The Emergency Department Using Cardiac Troponin and Glycemic Biomarkers. Clinical Chemistry. 63:593-602. 2017
- Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision. Clinical Chemistry. 63:585-592. 2017
- Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury. Clinical Chemistry. 63:37-44. 2017
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- Editorial commentary: High-sensitivity cardiac troponin: Like every new tool there is a learning curve. Trends in Cardiovascular Medicine. 27:48-50. 2017
- Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome. Clinical Chemistry. 63:403-414. 2017
- Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine. Hypoxic Signaling. Volume 5:61-66. 2017
- 1448: CHLORIDE CONCENTRATION OF COMMONLY AVAILABLE 5% HUMAN ALBUMIN SOLUTIONS. Critical Care Medicine. 44:437-437. 2016
- Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction. Circulation. 134:1532-1541. 2016
- Reality check for cardiac troponin testing – Sometimes the result is wrong. Clinical Biochemistry. 49:1107-1108. 2016
- Statistical issues with the determination of the troponin 99th percentile – Not just a problem for troponin?. Clinical Biochemistry. 49:1105-1106. 2016
- Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction. Heart. 102:1270-1278. 2016
- Adopting ‘ng/L’ as the units for high-sensitivity cardiac troponin assays and commitment by the entire health-care team could be the key for adopting recommendations. Annals of Clinical Biochemistry. 53:516-517. 2016
- Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study. Journal of Thoracic and Cardiovascular Surgery. 152:245-251.e4. 2016
- Carryover: More than just a major hangover for the clinical laboratory. Clinical Biochemistry. 49:735-736. 2016
- Acceptable Analytical Variation May Exceed High-Sensitivity Cardiac Troponin I Cutoffs in Early Rule-Out and Rule-In Acute Myocardial Infarction Algorithms. Clinical Chemistry. 62:887-889. 2016
- PL001: Derivation of a 2-hour high-sensitivity troponin T algorithm for rapid rule-out of acute myocardial infarction in emergency department chest pain patients. Canadian Journal of Emergency Medicine. 18:S29-S29. 2016
- The International Committee of Medical Journal Editors proposal for sharing clinical trial data and the possible implications for the peer review process. ANNALS OF TRANSLATIONAL MEDICINE. 4:115-115. 2016
- A STAR-Document for those interested in evaluating diagnostic research studies.. ANNALS OF TRANSLATIONAL MEDICINE. 4:45. 2016
- Error detection in routine clinical chemistry laboratory test results. Clinical Biochemistry. 49:199-200. 2016
- Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer. Vaccine Reports. 2:e00059-e00059. 2016
- Clinical Biochemistry 2015 year in review: Material not for the faint of heart. Clinical Biochemistry. 48:1211-1212. 2015
- Negative interference of N-acetyl cysteine (NAC) on selected chemistries on the Abbott architect platform. Clinica Chimica Acta. 451:219-221. 2015
- Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal of the American Society of Nephrology. 26:3123-3132. 2015
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- AN EVALUATION OF THE INCIDENCE AND PROGNOSIS OF POST CORONARY ARTERY BYPASS GRAFTING MYOCARDIAL INFARCTION ACCORDING TO DIFFERENT DEFINITIONS IN THE CORONARY TRIAL. Canadian Journal of Cardiology. 31:S161-S161. 2015
- AN EVENT DRIVEN MYOCARDIAL INFARCTION DEFINITION USING TROPONINS AFTER CORONARY ARTERY BYPASS SURGERY IN THE CORONARY TRIAL. Canadian Journal of Cardiology. 31:S161-S162. 2015
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P ost Exercise Cardiac TroponinI Release and Clearance in Normal Standardbred Racehorses. Equine Veterinary Journal. 47:27-28. 2015 - Hospital Admission and Myocardial Injury Prevalence after the Clinical Introduction of a High-Sensitivity Cardiac Troponin I Assay. Clinical Chemistry. 61:1209-1210. 2015
- Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery. Pediatric Nephrology. 30:1519-1527. 2015
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- Sex-specific cutoffs for cardiac troponin using high-sensitivity assays — Is there clinical equipoise?. Clinical Biochemistry. 48:749-750. 2015
- What is in that sample ? A pertinent question when assessing quality for patient laboratory results and beyond. Clinical Biochemistry. 48:465-466. 2015
- A practical approach for the validation and clinical implementation of a high-sensitivity cardiac troponin I assay across a North American city. Practical Laboratory Medicine. 1:28-34. 2015
- Cardiac Biomarkers and Acute Kidney Injury After Cardiac Surgery. Pediatrics. 135:e945-e956. 2015
- An approach to rule-out an acute cardiovascular event or death in emergency department patients using outcome-based cutoffs for high-sensitivity cardiac troponin assays and glucose. Clinical Biochemistry. 48:282-287. 2015
- Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain. Clinical Biochemistry. 48:288-291. 2015
- Matrix and bilirubin interference for high-sensitivity cardiac troponin I. Clinica Chimica Acta. 442:49-51. 2015
- Presenting characteristics of patients undergoing cardiac troponin measurements in the emergency department. Canadian Journal of Emergency Medicine. 17:62-66. 2015
- Assessment of the 99th or 97.5th Percentile for Cardiac Troponin I in a Healthy Pediatric Cohort. Clinical Chemistry. 60:1574-1576. 2014
- Clinical Biochemistry year in review — The clinical “good”, the analytical “bad”, and the “ugly” laboratory practices. Clinical Biochemistry. 47:255-256. 2014
- Canadian Institutes of Health Research dissemination grant on high-sensitivity cardiac troponin. Clinical Biochemistry. 47:155-157. 2014
- A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients. Investigational New Drugs. 32:1005-1016. 2014
- Centrifugation — an important pre-analytical factor for the Abbott Architect high-sensitivity cardiac troponin I assay. Clinica Chimica Acta. 436:273-275. 2014
- Metrics for identifying errors related to pre-analytical sample handling. Clinical Biochemistry. 47:989-990. 2014
- Assessing the necessity of including a crossover period with dual reporting when changing total prostate-specific antigen methods. Clinical Biochemistry. 47:897-900. 2014
- International comparisons of acute myocardial infarction. The Lancet. 384:304-304. 2014
- Within-run precision and outlier detection for the Abbott ARCHITECT cardiac troponin I assay. Annals of Clinical Biochemistry. 51:512-514. 2014
- Myocardial Injury after Noncardiac Surgery. Anesthesiology. 120:564-578. 2014
- Analytical factors to consider when assessing a high-sensitivity cardiac troponin I assay compared to a contemporary assay in clinical studies. Clinica Chimica Acta. 429:6-7. 2014
- Quality control material testing and the importance of “treating it like a patient's sample”. Clinical Biochemistry. 47:147-149. 2014
- High-Sensitivity Cardiac Troponin I for Predicting Death in a Female Emergency Department Population. Clinical Chemistry. 60:271-273. 2014
- Root cause analysis of delays to discharge for patients held for serial cardiac troponin levels. Canadian Journal of Emergency Medicine. 16:20-24. 2014
- Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome. Clinical Chemistry. 59:1407-1410. 2013
- Considerations for establishing a reference interval for elderly individuals in the emergency department with the high-sensitivity cardiac troponin T assay. Clinica Chimica Acta. 421:85-86. 2013
- A step closer in reducing hemolysis in blood samples collected in the emergency department. Clinical Biochemistry. 46:565-565. 2013
- Comparison of hs-cTnI, hs-cTnT, hFABP and GPBB for identifying early adverse cardiac events in patients presenting within six hours of chest pain-onset. Clinica Chimica Acta. 419:39-41. 2013
- High-Five for High-Sensitivity Cardiac Troponin T: Depends on the Precision and Analytical Platform. JAMA Internal Medicine. 173:477-477. 2013
- Implications of adjustment of high-sensitivity cardiac troponin T assay. Clinical Chemistry. 59:574-576. 2013
- Persistent Increases in Cardiac Troponin Concentrations As Measured with High-Sensitivity Assays after Acute Myocardial Infarction. Clinical Chemistry. 59:443-445. 2013
- Cardiac and Inflammation Biomarker Profile after Initiation of Adjuvant Trastuzumab Therapy. Clinical Chemistry. 59:327-329. 2013
- Predicting myocardial infarction and other serious cardiac outcomes using high-sensitivity cardiac troponin T in a high-risk stable population. Clinical Biochemistry. 46:5-9. 2013
- Assessment of a four hour delay for urine samples stored without preservatives at room temperature for urinalysis. Clinical Biochemistry. 45:856-858. 2012
- Error in Viewpoint in: Statin Therapy for Healthy Men Identified as ‘Increased Risk,’. Journal of the American Medical Association (JAMA). 307:2590-2590. 2012
- Assessing Pneumatic Tube Systems with Patient-Specific Populations and Laboratory-Derived Criteria. Clinical Chemistry. 58:792-795. 2012
- Dichotomizing High-Sensitivity Cardiac Troponin T Results and Important Analytical Considerations. Journal of the American College of Cardiology. 59:1570-1570. 2012
- Whether it is personalized, precision, or mechanistic medicine - the clinical laboratory has a role. Clinical Biochemistry. 45:384-384. 2012
- For a rapid diagnosis of acute myocardial infarction, a sensitive troponin assay is needed in the near-patient testing setting. Expert Review of Cardiovascular Therapy. 10:309-312. 2012
- Letter by Kavsak and MacRae Regarding Article, “Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction”. Circulation. 125:e358. 2012
- Risk Stratification in the Era of High-Sensitivity Troponin Assays. Annals of Emergency Medicine. 59:126-127. 2012
- Statistical and analytical approaches for assessing biomarkers: New approaches, new technologies, with the same-old rigor for evaluation. Clinical Biochemistry. 45:187-188. 2012
- Biomarkers for Predicting Serious Cardiac Outcomes at 72 Hours in Patients Presenting Early after Chest Pain Onset with Symptoms of Acute Coronary Syndromes. Clinical Chemistry. 58:298-302. 2012
- Effect of freeze–thaw and refrigeration conditions on high-sensitivity troponin T concentrations. Annals of Clinical Biochemistry. 49:101-102. 2012
- High-Sensitivity Cardiac Troponin Assays—Change Is Important. Clinical Chemistry. 58:311-313. 2012
- The ABCs of clinical biochemistry. Clinical Biochemistry. 45:1-2. 2012
- Autism spectrum disorder: When biochemical and genetic profiles don't match — Is sample size and selection bias the culprit?. Clinical Biochemistry. 44:1358-1358. 2011
- Cardiac troponin testing in the acute care setting: Ordering, reporting, and high sensitivity assays—An update from the Canadian society of clinical chemists (CSCC). Clinical Biochemistry. 44:1273-1277. 2011
- An Alternative Approach for Detecting Interferences in Enzymatic Acetaminophen Assays. Clinical Chemistry. 57:1203-1204. 2011
- High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clinical Biochemistry. 44:1021-1024. 2011
- High-Sensitivity Cardiac Troponin I Measurement for Risk Stratification in a Stable High-Risk Population. Clinical Chemistry. 57:1146-1153. 2011
- Early standardization of high sensitivity troponin T reporting - a lost opportunity. Clinical Biochemistry. 44:758-759. 2011
- Highly Sensitive Cardiac Troponin T Assay, Cardiac Disease, and Mortality Risk. Journal of the American Medical Association (JAMA). 305:1196-1196. 2011
- Cardiac Troponin Cutoffs: The Importance of Assay Sensitivity and the Patient Population. Journal of Clinical Oncology. 29:e177-e177. 2011
- Troponin levels in hemodialysis patients: interpretation based on guidelines, changing concentrations and high-sensitivity assays. Nephrology Dialysis Transplantation. 26:1112-1113. 2011
- Letter by Kavsak et al Regarding Article, “B-Type Natriuretic Peptide Signal Peptide Circulates in Human Blood: Evaluation as a Potential Biomarker of Cardiac Ischemia”. Circulation. 123:e233. 2011
- Multiplex protein assay performance/evaluation and the requirement for precision and correlation to clinical assays. Clinical Chemistry and Laboratory Medicine. 49:1915-1918. 2011
- Increasing Cardiac Troponin Changes Measured by a Research High-Sensitivity Troponin I Assay: Absolute vs Percentage Changes and Long-Term Outcomes in a Chest Pain Cohort. Clinical Chemistry. 56:1902-1904. 2010
- High sensitivity cardiac troponin testing. CANADIAN MEDICAL ASSOCIATION JOURNAL. 182:1761-1761. 2010
- Sensitive and high sensitivity cardiac troponin I concentrations in the Heart Outcomes Prevention Evaluation (HOPE) study — A high risk population. Clinica Chimica Acta. 411:1832-1832. 2010
- High sensitivity cardiac troponin concentration cutoffs—is a healthy population the right reference population for those with underlying cardiac disease?. Clinical Biochemistry. 43:1037-1038. 2010
- Second and first trimester estimation of risk for Down syndrome: implementation and performance in the SAFER study. Prenatal Diagnosis. 30:459-466. 2010
- Identification of myocardial injury in the emergency setting. Clinical Biochemistry. 43:539-544. 2010
- 2007 Universal Myocardial Infarction Definition Change Criteria for Risk Stratification by Use of a High-Sensitivity Cardiac Troponin I Assay. Clinical Chemistry. 56:487-489. 2010
- The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department. Clinical Biochemistry. 43:505-507. 2010
- Vascular Endothelial Growth Factor Concentration as a Predictive Marker: Ready for Primetime?. Clinical Cancer Research. 16:1341-1341. 2010
- Peripheral Blood Monocyte Subset Assessment in Non–ST-Segment Elevation Myocardial Infarction Is Required. Journal of the American College of Cardiology. 55:169-169. 2010
- Serial cardiac troponin T measurements in haemodialysis patients: absolute versus changing concentrations?. Annals of Clinical Biochemistry. 47:97-97. 2010
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- Another potential marker linking gender and cardiac mortality: PAPP-A — A new marker in risk stratification for women presenting with chest pain. Clinica Chimica Acta. 408:139-140. 2009
- Short- and Long-Term Risk Stratification Using a Next-Generation, High-Sensitivity Research Cardiac Troponin I (hs-cTnI) Assay in an Emergency Department Chest Pain Population. Clinical Chemistry. 55:1809-1815. 2009
- Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel anti-metastasis agent. Clinical Biochemistry. 42:1162-1165. 2009
- PAPP-A as a marker of increased long-term risk in patients with chest pain. Clinical Biochemistry. 42:1012-1018. 2009
- Analytic and Clinical Utility of a Next-Generation, Highly Sensitive Cardiac Troponin I Assay for Early Detection of Myocardial Injury. Clinical Chemistry. 55:573-577. 2009
- Cytokine elevations in acute coronary syndrome and ovarian cancer: A mechanism for the up-regulation of the acute phase proteins in these different disease etiologies. Clinical Biochemistry. 41:607-610. 2008
- Cardiotoxicity associated with sunitinib. The Lancet. 371:1244-1244. 2008
- Is a Pattern of Increasing Biomarker Concentrations Important for Long-Term Risk Stratification in Acute Coronary Syndrome Patients Presenting Early after the Onset of Symptoms?. Clinical Chemistry. 54:747-751. 2008
- Vascular versus myocardial dysfunction in acute coronary syndrome: Are the adhesion molecules as powerful as NT-proBNP for long-term risk stratification?. Clinical Biochemistry. 41:436-439. 2008
- “Upstream markers” provide for early identification of patients at high risk for myocardial necrosis and adverse outcomes. Clinica Chimica Acta. 387:133-138. 2008
- Risk Stratification for Heart Failure and Death in an Acute Coronary Syndrome Population Using Inflammatory Cytokines and N-Terminal Pro-Brain Natriuretic Peptide. Clinical Chemistry. 53:2112-2118. 2007
- Use of an interferon-gamma based assay to assess bladder cancer patients treated with intravesical BCG and exposed to tuberculosis. Clinical Biochemistry. 40:913-915. 2007
- Authors' response to Apple editorial. Clinica Chimica Acta. 380:245-246. 2007
- Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clinica Chimica Acta. 380:213-216. 2007
- Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure. Clinical Biochemistry. 40:326-329. 2007
- Long-Term Health Outcomes Associated with Detectable Troponin I Concentrations. Clinical Chemistry. 53:220-227. 2007
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- Health Outcomes Categorized by Current and Previous Definitions of Acute Myocardial Infarction in an Unselected Cohort of Troponin-Naïve Emergency Department Patients. Clinical Chemistry. 52:2028-2035. 2006
- The impact of the ESC/ACC redefinition of myocardial infarction and new sensitive troponin assays on the frequency of acute myocardial infarction. American Heart Journal. 152:118-125. 2006
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- Assessing the Requirement for the 6-Hour Interval between Specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clinical Chemistry. 52:812-818. 2006
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- Detectable high-sensitivity cardiac troponin concentrations and risk stratification in the emergency setting. Journal of Laboratory and Precision Medicine. 3:64-64.
- Does the LoD cutoff + the TIMI score = a NICE approach to rule-out a major adverse cardiac event in the emergency department?. Journal of Laboratory and Precision Medicine. 2:92-92.
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