Assessing the necessity of including a crossover period with dual reporting when changing total prostate-specific antigen methods

OBJECTIVES: Options are limited for the laboratory when changing analytical methods for tumor markers. Standardization between methods should alleviate this burden. Our objective was to assess the necessity of dual reporting for total prostate-specific antigen (tPSA) when changing methods that have been calibrated against the World Health Organization PSA reference material. DESIGN AND METHODS: Following an initial validation where 40 patient …