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Determination of Clinically Acceptable Analytical...
Journal article

Determination of Clinically Acceptable Analytical Variation of Cardiac Troponin at Decision Thresholds

Abstract

BACKGROUND: Clinical decision-making for risk stratification for possible myocardial infarction (MI) uses high-sensitivity cardiac troponin (hs-cTn) thresholds that range from the limit of detection to several-fold higher than the upper reference limit (URL). To establish a minimum analytical variation standard, we can quantify the effect of variation on the population clinical measures of safety (sensitivity) and effectiveness [proportion …

Authors

Pickering JW; Kavsak P; Christenson RH; Troughton RW; Pemberton CJ; Richards AM; Joyce L; Than MP

Journal

Clinical Chemistry, Vol. 70, No. 7, pp. 967–977

Publisher

Oxford University Press (OUP)

Publication Date

July 5, 2024

DOI

10.1093/clinchem/hvae059

ISSN

0009-9147