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Biochip arrays for the discovery of a biomarker...

Journal article

Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel anti-metastasis agent

Abstract

OBJECTIVE: Can biochip arrays identify which individuals with metastatic disease will respond to an anti-metastatic agent? DESIGN AND METHODS: Cytokine and cell adhesion arrays (Randox Ltd) were measured over 1 month in 9 research participants receiving CTCE-9908 in a Phase I/II study. RESULTS: Research participants with stable disease (n=2) had significantly higher soluble VCAM-1 as compared to those that progressed. DISCUSSION: VCAM-1 measurement early during CTCE-9908 treatment might be used as a surrogate for response.

Authors

Kavsak PA; Henderson M; Moretto P; Hirte H; Evans K; Wong D; Korz W; Hotte SJ

Journal

Clinical Biochemistry, Vol. 42, No. 10-11, pp. 1162–1165

Publisher

Elsevier

Publication Date

July 1, 2009

DOI

10.1016/j.clinbiochem.2009.04.008

ISSN

0009-9120

Associated Experts

Holger Hirte

Professor Emeritus, Faculty of Health Sciences

Peter Kavsak

Professor, Faculty of Health Sciences

Sebastien Hotte

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3202 Clinical sciences 3205 Medical biochemistry and metabolomics

Medical Subject Headings (MeSH)

Adult Aged Antineoplastic Agents Biomarkers, Tumor Cell Adhesion Molecules Cytokines Demography Drug Screening Assays, Antitumor Female Humans Male Middle Aged Neoplasm Metastasis Peptides Protein Array Analysis

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