selected scholarly activity
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academic article
- Identification of Endocannabinoid Predictors of Treatment Outcomes in Major Depressive Disorder: A Secondary Analysis of the First Canadian Biomarker Integration Network in Depression (CAN-BIND 1) Study. Pharmacopsychiatry. 55:297-303. 2022
- Immune characterization of suicidal behavior in female adolescents. Brain, Behavior, & Immunity - Health. 25:100499-100499. 2022
- Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study. Translational Psychiatry. 12:366. 2022
- Acute and chronic stress predict anti-depressant treatment outcome and naturalistic course of major depression: A CAN-BIND report. Journal of Affective Disorders. 313:8-14. 2022
- “One Degree of Separation”: A Mixed-Methods Evaluation of Canadian Mental Health Care User and Provider Experiences With Remote Care During COVID-19. Canadian Journal of Psychiatry. 67:712-722. 2022
- Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse models. NeuroImage. 257:119243-119243. 2022
- Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype. Molecular Psychiatry. 27:3047-3055. 2022
- Modulating brain function with microbiota. Science The Scientific monthly. 376:936-937. 2022
- Microbe-Immune Crosstalk: Evidence That T Cells Influence the Development of the Brain Metabolome. International Journal of Molecular Sciences. 23:3259-3259. 2022
- Diet and depression: future needs to unlock the potential. Molecular Psychiatry. 27:778-780. 2022
- Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders. Frontiers in Psychiatry. 13:816465. 2022
- Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A Canadian Biomarker Integration Network for Depression Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. S2451-9022(22)00015-5. 2022
- Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report. Translational Psychiatry. 11:469. 2021
- Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis. Psychological Medicine. 51:2742-2751. 2021
- Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report. Communications Biology. 4:903. 2021
- Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response. Molecular Psychiatry. 26:7417-7424. 2021
- Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response. Translational Psychiatry. 11:439. 2021
- Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report. Psychoneuroendocrinology. 132:105348-105348. 2021
- Metabolic variables associated with response to cognitive behavioural therapy for depression in females: A Canadian biomarker integration network for depression (CAN-BIND) study. Journal of Psychiatric Research. 142:321-327. 2021
- Intestinal permeability correlates with behavioural severity in very young children with ASD: A preliminary study. Journal of Neuroimmunology. 357:577607-577607. 2021
- Microbiota‐immune alterations in adolescents following early life adversity: A proof of concept study. Developmental Psychobiology. 63:851-863. 2021
- The effect of early life immune challenge on adult forced swim test performance and hippocampal neurogenesis. Journal of Neuroimmunology. 354:577530-577530. 2021
- Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response. Translational Psychiatry. 11:127. 2021
- Diet and depression: exploring the biological mechanisms of action. Molecular Psychiatry. 26:134-150. 2021
- Is Anxiety Associated with the Gut Microbiota?. Mod Trends Psychiatry. 32:68-73. 2021
- The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder. Frontiers in Neurology. 12:721126. 2021
- A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol. BMC Psychiatry. 20:268. 2020
- GPR56/ADGRG1 is associated with response to antidepressant treatment. Nature Communications. 11:1635. 2020
- Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report. Neuropsychopharmacology. 45:1390-1397. 2020
- Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?. Frontiers in Neuroendocrinology. 58:100849-100849. 2020
- THE DEPRESSION INVENTORY DEVELOPMENT SCALE: Assessment of Psychometric Properties Using Classical and Modern Measurement Theory in a CAN-BIND Trial.. Innovations in Clinical Neuroscience. 17:30-40. 2020
- Symptom Dimension of Interest-Activity Indicates Need for Aripiprazole Augmentation of Escitalopram in Major Depressive Disorder. Journal of Clinical Psychiatry. 81:20m13229. 2020
- Loss of T cells influences sex differences in stress-related gene expression. Journal of Neuroimmunology. 343:577213-577213. 2020
- Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine. Progress in Neuro-Psychopharmacology and Biological Psychiatry Progress in Neuro-Psychopharmacology. 100:109867-109867. 2020
- Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report. International Journal of Neuropsychopharmacology. 23:88-95. 2020
- Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression. Jama Network Open. 3:e1918377-e1918377. 2020
- Decoding Microbiome Research for Clinical Psychiatry. Canadian Journal of Psychiatry. 65:19-20. 2020
- The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial. Neuropsychobiology International Pharmacopsychiatry. 79:108-116. 2020
- Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants. Translational Psychiatry. 9:254. 2019
- Gut microbial metabolites in depression: understanding the biochemical mechanisms. Microbial Cell. 6:454-481. 2019
- The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols. Journal of Psychiatry and Neuroscience Psychiatric Journal of the University of Ottawa. 44:223-236. 2019
- Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment. Journal of Clinical Psychiatry. 80:18m12556. 2019
- Microbe and host interaction in gastrointestinal homeostasis. Psychopharmacology. 236:1623-1640. 2019
- Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder. Journal of Clinical Psychiatry. 80:18m12202. 2019
- A pilot dose finding study of pioglitazone in autistic children. Molecular Autism. 9:59. 2018
- Mouse MRI shows brain areas relatively larger in males emerge before those larger in females. Nature Communications. 9:2615. 2018
- Genome-wide association studies of placebo and duloxetine response in major depressive disorder. Pharmacogenomics Journal. 18:406-412. 2018
- Effects of exercise and enrichment on behaviour in CD-1 mice. Behavioural Brain Research. 342:43-50. 2018
- GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. Journal of Psychiatric Research. 99:62-68. 2018
- The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study. Journal of Affective Disorders. 227:542-549. 2018
- Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder. Frontiers in Psychiatry. 9:513. 2018
- Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology of Stress. 7:124-136. 2017
- Targeting the Microbiome for Mental Health: Hype or Hope?. Biological Psychiatry. 82:456-457. 2017
- Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response. International Journal of Neuropsychopharmacology. 20:619-623. 2017
- MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature Communications. 8:15497. 2017
- The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression. European Archives of Psychiatry and Clinical Neuroscience. 267:135-147. 2017
- Lactobacillus rhamnosusstrain JB-1 reverses restraint stress-induced gut dysmotility. Neurogastroenterology and Motility. 29:e12903-e12903. 2017
- Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities. Psychotherapy and Psychosomatics. 86:31-46. 2017
- Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry. 16:105. 2016
- The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. BMC Psychiatry. 16:61. 2016
- White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms. Psychiatry Research - Neuroimaging. 253:15-25. 2016
- White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms. Psychiatry Research - Neuroimaging. 253:15-25. 2016
- Gut Microbiota and Brain Function: An Evolving Field in Neuroscience: Table 1.. International Journal of Neuropsychopharmacology. 19:pyv114-pyv114. 2016
- Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5-HTTLPR-S/Lg polymorphisms. Human Psychopharmacology. 31:144-155. 2016
- Developmental expression of the neuroligins and neurexins in fragile X mice. Journal of Comparative Neurology. 524:807-828. 2016
- Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain. Neuroscience. 318:12-21. 2016
- Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology. 63:217-227. 2016
- Zebrafish models of major depressive disorders. Journal of Neuroscience Research. 94:3-14. 2016
- Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. Pharmacogenomics. 16:1919-1929. 2015
- Loss of T cells influences sex differences in behavior and brain structure. Brain, Behavior, and Immunity. 46:249-260. 2015
- Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression. Current Opinion in Biotechnology. 32:35-41. 2015
- 3D visualization of the regional differences. Molecular Psychiatry. 20:1-1. 2015
- Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Molecular Psychiatry. 20:118-125. 2015
- Nucleus accumbens core and pathogenesis of compulsive checking. Behavioural Pharmacology. 26:200-216. 2015
- Psychobiotics and the gut–brain axis: in the pursuit of happiness. Neuropsychiatric Disease and Treatment. 11:715-715. 2015
- Performance of compulsive behavior in rats is not a unitary phenomenon – validation of separate functional components in compulsive checking behavior. European Journal of Neuroscience. 40:2971-2979. 2014
- Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: Therapeutic implications for Alzheimer's disease. Neuroscience Letters. 576:84-87. 2014
- Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development. Behavioural Brain Research. 259:119-130. 2014
- Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences. 36:305-312. 2013
- In utero exposure to valproic acid and autism — A current review of clinical and animal studies. Neurotoxicology and Teratology. 36:47-56. 2013
- The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterology and Motility. 25:183-e88. 2013
- The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes. 4:17-27. 2013
- Developmental alterations in CNS stress-related gene expression following postnatal immune activation. Neuroscience. 220:90-99. 2012
- Loss of class I MHC function alters behavior and stress reactivity. Journal of Neuroimmunology. 244:8-15. 2012
- Impact of Treadmill Running and Sex on Hippocampal Neurogenesis in the Mouse Model of Amyotrophic Lateral Sclerosis. PLoS ONE. 7:e36048-e36048. 2012
- Depression in Women. Journal of Clinical Psychiatry. 72:e1563-e1569. 2011
- Effects of intestinal microbiota on anxiety-like behavior. Communicative and Integrative Biology. 4:492-494. 2011
- Effects of intestinal microbiota on anxiety-like behavior.. Communicative and Integrative Biology. 4:492-494. 2011
- Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterology and Motility. 23:255-e119. 2011
- A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. 171:734-746. 2010
- Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice. Gastroenterology. 139:2102-2112.e1. 2010
- Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. European Journal of Neuroscience. 32:1552-1563. 2010
- Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid. Neuroscience. 170:514-522. 2010
- The rapid effects of estrogen: a mini-review. Behavioural Pharmacology. 21:465-472. 2010
- Validation of an automated system for measuring anxiety-related behaviours in the elevated plus maze. Journal of Neuroscience Methods. 188:7-13. 2010
- Evidence for neuronal expression of functional Fc (ε and γ) receptors. Journal of Allergy and Clinical Immunology. 125:757-760. 2010
- Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.) Experimental Biology and Medicine. 235:66-76. 2010
- Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice. Neuroscience. 163:1201-1210. 2009
- Effects of gut microbiota on the brain: implications for psychiatry.. Journal of Psychiatry and Neuroscience Psychiatric Journal of the University of Ottawa. 34:230-231. 2009
- Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 296:R587-R594. 2009
- Proclivity to self-injurious behavior in MRL-lpr mice: implications for autoimmunity-induced damage in the dopaminergic system. Molecular Psychiatry. 13:1043-1053. 2008
- Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal. American Journal of Physiology - Gastrointestinal and Liver Physiology. 295:G691-G699. 2008
- Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategy in a dendritic cell–induced peanut allergy model. Journal of Allergy and Clinical Immunology. 122:55-61.e7. 2008
- Neurobiological Factors Linking Personality Traits and Major Depression. Canadian Journal of Psychiatry. 53:6-13. 2008
- Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats. Psychopharmacology. 194:485-496. 2007
- Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mice. Journal of Neuroimmunology. 179:26-36. 2006
- cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects. Pharmacogenomics Journal. 6:131-140. 2006
- Expression of a killer cell receptor-like gene in plastic regions of the central nervous system. Journal of Neuroimmunology. 161:177-182. 2005
- Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizures. Journal of Comparative Neurology. 476:91-102. 2004
- Kainic acid lesion-induced nigral neuronal death. Journal of Chemical Neuroanatomy. 26:65-73. 2003
- Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models. Journal of Neuroimmunology. 131:83-91. 2002
- GTP cyclohydrolase I induction in striatal astrocytes following intrastriatal kainic acid lesion. Journal of Chemical Neuroanatomy. 24:173-179. 2002
- Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation. Neuroscience. 112:731-749. 2002
- Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia nigra during development. Neurochemistry International. 39:127-133. 2001
- Evidence of deprenyl-insensitive apoptosis of nigral dopamine neurons during development. Developmental Brain Research. 120:95-98. 2000
- Differential induction of heat shock mRNA in oligodendrocytes, microglia, and astrocytes following hyperthermia. Brain Research Brain Research Protocols Molecular Brain Research. 45:207-218. 1997
- Intracellular localization of heat shock mRNAs (hsc70 and hsp70) to neural cell bodies and processes in the control and hyperthermic rabbit brain. Journal of Neuroscience Research. 46:652-665. 1996
- Basal expression of stress-inducible hsp70 mRNA detected in hippocampal and cortical neurons of normal rabbit brain. Brain Research Brain Research Protocols Molecular Brain Research. 724:73-83. 1996
- Localization of constitutive and hyperthermia-inducible heat shock mRNAS (hsc70 and hsp70) in the rabbit cerebellum and brainstem by non-radioactive in situ hybridization. Journal of Neuroscience Research. 41:603-612. 1995
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book
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chapter
- Chapter 13 More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression. 137-145. 2019
- More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression. 137-145. 2019
- Gut Microbiome and Behavior. International Review of Neurobiology. 49-65. 2016
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conference paper
- Relationship between epigenetic markers and hypothalamus volumes in major depressive disorder. Bipolar Disorders. 57-57. 2020
- M31 IMPACT OF CYP2C19 AND CYP2D6 GENE VARIANTS ON PLASMA LEVELS AND TREATMENT RESPONSE IN PATIENTS RECEIVING ESCITALOPRAM AND ARIPIPRAZOLE FOR MAJOR DEPRESSION: RESULTS FROM THE CAN-BIND-1 COHORT. European Neuropsychopharmacology. S183-S183. 2019
- F107. Cortical Thickness Features Differentiate 16-Week Antidepressant Response Profiles in Major Depressive Disorder. Biological Psychiatry. S254-S254. 2019
- S124. Impact of CYP2C19 and CYP2D6 Genotypes on Clinical Outcomes and Side Effects in Patients Receiving Escitalopram and Aripiprazole for Major Depression: Results From the Can-Bind Cohort. Biological Psychiatry. S344-S345. 2019
- GWAS-BASED MACHINE LEARNING APPROACH TO PREDICT DULOXETINE RESPONSE AND REMISSION IN MAJOR DEPRESSIVE DISORDER. European Neuropsychopharmacology. S843-S843. 2019
- Impact of CYP2C19 and CYP2D6 Genotypes on Clinical Outcomes and Side Effects in Patients Receiving Escitalopram and Aripiprazole for Major Depression: Results From the Can-Bind Cohort. Neuropsychopharmacology. S118-S119. 2018
- THE EFFICACY, SAFETY, AND TOLERABILITY OF PROBIOTICS ON SYMPTOMS OF DEPRESSION: RESULTS FROM A PILOT STUDY. Annales Nestle Annals of Nutrition and Metabolism. 55-55. 2018
- GENOME-WIDE ASSOCIATION STUDY IN DULOXETINE AND PLACEBO RESPONSE. European Neuropsychopharmacology. S245-S246. 2017
- GWAS-BASED MACHINE LEARNING APPROACH TO PREDICT DULOXETINE RESPONSE IN MAJOR DEPRESSIVE DISORDER. European Neuropsychopharmacology. S285-S286. 2017
- Childhood maltreatment and markers of neuroinflammation predict response to anti-depressant treatment in adults with major depressive disorder. Psychoneuroendocrinology. 73-73. 2017
- 751. The Role of Childhood Maltreatment in Depression: Overview of the Literature and Insights from the CAN-BIND Program. Biological Psychiatry. S304-S305. 2017
- 754. Inflammatory Markers as Mediators of the Association between Early Life Adversity and Hippocampal Volume in Adult Patients with depression: Findings from Phase 1 of the CAN-BIND Study. Biological Psychiatry. S306-S306. 2017
- Genome-Wide Association Study of Duloxetine and Placebo Response in Major Depressive Disorder. Genetic Epidemiology. 652-652. 2016
- Genome-wide Association Study of Duloxetine and Placebo Response in Major Depressive Disorder. Biological Psychiatry. 130S-131S. 2016
- Genome-Wide Association Analyses on Clinical Response to Duloxetine and Placebo in Major Depression Implicates a Gene Locus Involved in Nociception to be Associated with Placebo Response. Neuropsychopharmacology. S497-S497. 2015
- ISDN2014_0194: Behaviour and neuroanatomy in Angelman Syndrome mice. International Journal of Developmental Neuroscience. 57-57. 2015
- S.20.04 Gut-brain communication: how the microbiome influences anxiety and depression. European Neuropsychopharmacology. S141-S141. 2015
- P.1.i.034 The impact of 5-HTTLPR and BDNF Val66Met on heterogeneity of intrinsic connectivity of amygdala in major depressive disorder. European Neuropsychopharmacology. S317-S317. 2014
- Gut-brain axis: How the microbiome influences anxiety and depression. International Journal of Neuropsychopharmacology. 27-27. 2014
- Amygdala Responses as Neuroimaging Endpoint Marker for Antidepressant Efficacy in Patients with Major Depression and High Risk Alleles of Serotonin Transporter Gene Polymorphism. Biological Psychiatry. 239S-240S. 2014
- The microbiome is necessary for normal gut intrinsic primary afferent neuron excitability. Neurogastroenterology and Motility. 12-13. 2011
- Gene Expression of Estrogen Receptor alpha and Serotonin Transporter in Women with Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Biological Psychiatry. 55S-55S. 2010
- Risk Alleles of the Serotonin Transporter Polymorphism Predict Small Hippocampal Volumes in Major Depression. Biological Psychiatry. 232S-232S. 2009
- Effects of probiotics on gut-brain axis during chronic H-pylori infection. Gastroenterology. A97-A97. 2008
- HEAT-SHOCK STRESS PROTEINS IN THE MAMMALIAN BRAIN. Journal of Neurochemistry. S190-S190. 1993