Journal article
Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid
Abstract
Experiments in rodents have indicated that maternal valproic acid (VPA) exposure has permanent adverse effects upon neurological and behavioral development. In humans, prenatal exposure to VPA can induce fetal valproate syndrome, which has been associated with autism. The present study examined mouse pups exposed in utero to VPA, measuring physical development, olfactory discrimination, and social behavior as well as expression of …
Authors
Roullet FI; Wollaston L; deCatanzaro D; Foster JA
Journal
Neuroscience, Vol. 170, No. 2, pp. 514–522
Publisher
Elsevier
Publication Date
October 2010
DOI
10.1016/j.neuroscience.2010.06.069
ISSN
0306-4522