Journal article
Genetic variation in IL-1, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder
Abstract
AIM: This study investigated polymorphisms of five inflammatory-related genes for association with duloxetine and placebo response in patients with major depression.
PATIENTS & METHODS: Twenty SNPs in IL-1β, IL-2, IL-6, TSPO and BDNF were genotyped in major depressive disorder patients treated with either duloxetine (n = 215) or placebo (n = 235) for up to 8 weeks. Treatment response was measured with the Montgomery-Åsberg Depression Rating …
Authors
Maciukiewicz M; Marshe VS; Tiwari AK; Fonseka TM; Freeman N; Rotzinger S; Foster JA; Kennedy JL; Kennedy SH; Mller DJ
Journal
Pharmacogenomics, Vol. 16, No. 17, pp. 1919–1929
Publisher
Taylor & Francis
Publication Date
November 2015
DOI
10.2217/pgs.15.136
ISSN
1462-2416