Journal article
Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: Therapeutic implications for Alzheimer's disease
Abstract
We have reported that clinically relevant concentrations of valproic acid (VPA) upregulate the G protein-coupled melatonin MT1 receptor in rat C6 glioma cells, and both MT1 and MT2 receptors in the rat hippocampus. The melatonin MT2 receptor is relatively enriched in the hippocampus, where it is thought to be involved in modulating synaptic plasticity and cognitive function. Importantly, a significant decrease in MT2 expression has been …
Authors
Bahna SG; Sathiyapalan A; Foster JA; Niles LP
Journal
Neuroscience Letters, Vol. 576, , pp. 84–87
Publisher
Elsevier
Publication Date
July 2014
DOI
10.1016/j.neulet.2014.05.056
ISSN
0304-3940