Journal article
Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategy in a dendritic cell–induced peanut allergy model
Abstract
BACKGROUND: Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4 plays an important role in the initiation of T(H)2 polarization. This study aims to elucidate the mechanisms of peanut allergy mediated by microbial products and DCs and the relationship between peanut allergy and TIM4.
METHODS: Mouse bone marrow-derived DCs (BMDCs) were generated and exposed to cholera toxin (CT) or/and …
Authors
Feng B-S; Chen X; He S-H; Zheng P-Y; Foster J; Xing Z; Bienenstock J; Yang P-C
Journal
Journal of Allergy and Clinical Immunology, Vol. 122, No. 1, pp. 55–61.e7
Publisher
Elsevier
Publication Date
July 2008
DOI
10.1016/j.jaci.2008.04.036
ISSN
0091-6749