selected scholarly activity
-
academic article
- Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B. mBio. 14:e0314922. 2023
- A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling inPseudomonas aeruginosa 2022
- Exploration of BAY 11-7082 as a Potential Antibiotic. ACS Infectious Diseases. 8:170-182. 2022
- The Impact of COVID-19 on Outpatient Antibiotic Prescriptions in Ontario, Canada; An Interrupted Time Series Analysis. Open Forum Infectious Diseases. 8:ofab533. 2021
- Exploration of BAY 11-7082 as a novel antibiotic 2021
- Thiocillin and micrococcin exploit the ferrioxamine receptor of Pseudomonas aeruginosa for uptake. Journal of Antimicrobial Chemotherapy. 76:2029-2039. 2021
- How to kill Pseudomonas —emerging therapies for a challenging pathogen. Annals of the New York Academy of Sciences. 1496:59-81. 2021
- Coronavirus Disease 2019 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies. Clinical Infectious Diseases. 72:1657-1659. 2021
- CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP. Structure Structure with Folding & design. 29:457-466.e4. 2021
- Thiopeptides: antibiotics with unique chemical structures and diverse biological activities. Japanese Journal of Antibiotics Journal of Antibiotics. 74:161-175. 2021
- More than a Feeling: Microscopy Approaches to Understanding Surface-Sensing Mechanisms. Journal of Bacteriology. 203:JB.00492-JB.00420. 2021
- Heads or tails for type V pilus assembly. Nature Microbiology. 5:782-784. 2020
- Forging New Antibiotic Combinations under Iron-Limiting Conditions. Antimicrobial Agents and Chemotherapy. 64:e01909-e01919. 2020
- Multiple conformations facilitate PilT function in the type IV pilus. Nature Communications. 10:5198. 2019
- Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 63:e00472-e00419. 2019
- The Dynamic Structures of the Type IV Pilus. Microbiology spectrum. 7. 2019
- Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials. Current Opinion in Microbiology. 45:164-169. 2018
- The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities. mBio. 9:e01310-e01318. 2018
- The Therapeutic Pipeline for Pseudomonas aeruginosa Infections. ACS Infectious Diseases. 4:1041-1047. 2018
- A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly. ACS Infectious Diseases. 4:936-943. 2018
- Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity. PLoS Pathogens. 14:e1007074-e1007074. 2018
- Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Scientific Reports. 8:2600. 2018
- Diversity and Evolution of Myxobacterial Type IV Pilus Systems. Frontiers in Microbiology. 9:1630. 2018
- Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation. Nature Microbiology. 3:47-52. 2018
- PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa. Journal of Biological Chemistry. 292:19411-19422. 2017
- Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa. Journal of Bacteriology. 199:e00188-e00117. 2017
- The molecular mechanism of the type IVa pilus motors. Nature Communications. 8:15091. 2017
- Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 114:2892-2897. 2017
- The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division. mBio. 8:e02103-e02116. 2017
- Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis. Journal of Biomedical Science. 23:20. 2016
- Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. Structure Structure with Folding & design. 24:1778-1787. 2016
- Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo. Journal of Biological Chemistry. 291:19923-19938. 2016
- The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions. Journal of Bacteriology. 198:2263-2274. 2016
- Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development. Future Medicinal Chemistry. 8:975-992. 2016
- Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS. Proceedings of the National Academy of Sciences of the United States of America. 113:6017-6022. 2016
- PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. Journal of Biological Chemistry. 291:11003-11015. 2016
- The type IVa pilus machinery is pre-installed during cell division 2016
- Loss of membrane‐bound lytic transglycosylases increases outer membrane permeability andβ‐lactam sensitivity inPseudomonas aeruginosa. MicrobiologyOpen. 4:879-895. 2015
- Biogenesis ofPseudomonas aeruginosatype IV pili and regulation of their function. Environmental Microbiology. 17:4148-4163. 2015
- Structural and Functional Studies of the Pseudomonas aeruginosa Minor Pilin, PilE. Journal of Biological Chemistry. 290:26856-26865. 2015
- Novel Role for PilNO in Type IV Pilus Retraction Revealed by Alignment Subcomplex Mutations. Journal of Bacteriology. 197:2229-2238. 2015
- Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili. Biophysical Journal. 108:2865-2875. 2015
- Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa. Journal of Biological Chemistry. 290:12451-12462. 2015
- Pseudomonas aeruginosa Minor Pilins Prime Type IVa Pilus Assembly and Promote Surface Display of the PilY1 Adhesin. Journal of Biological Chemistry. 290:601-611. 2015
- Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations. Antimicrobial Agents and Chemotherapy. 58:6508-6517. 2014
- DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms. International Journal of Food Microbiology. 187:26-32. 2014
- A New Twist in the Assembly of Type IV Pilus-like Fibers. Structure Structure with Folding & design. 22:659-661. 2014
- The dynamics of peptidoglycan structure and function: Conference report on the 3rd Great Wall Symposium. Research in Microbiology. 165:60-67. 2014
- A new route for polar navigation. Molecular Microbiology Microbiological Sciences. 90:919-922. 2013
- Changes to Its Peptidoglycan-Remodeling Enzyme Repertoire Modulate β-Lactam Resistance in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 57:3078-3084. 2013
- PilMNOPQ from the Pseudomonas aeruginosa Type IV Pilus System Form a Transenvelope Protein Interaction Network That Interacts with PilA. Journal of Bacteriology. 195:2126-2135. 2013
- Functional Mapping of PilF and PilQ in the Pseudomonas aeruginosa Type IV Pilus System. Biochemistry. 52:2914-2923. 2013
- The Platform Protein Is Essential for Type IV Pilus Biogenesis. Journal of Biological Chemistry. 288:9721-9728. 2013
- The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria. PLoS ONE. 8:e60666-e60666. 2013
- Type IV Pilin Proteins: Versatile Molecular Modules. Microbiology and Molecular Biology Reviews. 76:740-772. 2012
- Prime time for minor subunits of the type II secretion and type IV pilus systems. Molecular Microbiology Microbiological Sciences. 86:765-769. 2012
- Inhibition of Bacterial Biofilm Formation and Swarming Motility by a Small Synthetic Cationic Peptide. Antimicrobial Agents and Chemotherapy. 56:2696-2704. 2012
- Decoding the roles of pilotins and accessory proteins in secretin escort services. FEMS Microbiology Letters. 328:1-12. 2012
- Small-Molecule Modulators of Listeria monocytogenes Biofilm Development. Applied and Environmental Microbiology. 78:1454-1465. 2012
- Palmitoyl-dl-Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development. ChemBioChem. 12:2759-2766. 2011
- Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. Molecular Microbiology Microbiological Sciences. 82:1496-1514. 2011
- Intravital Microscopy of the Murine Urinary Bladder Microcirculation. Microcirculation. 18:613-622. 2011
- Pseudomonas aeruginosa d-Arabinofuranose Biosynthetic Pathway and Its Role in Type IV Pilus Assembly. Journal of Biological Chemistry. 286:28128-28137. 2011
- Maintaining network security: how macromolecular structures cross the peptidoglycan layer. FEMS Microbiology Letters. 318:1-9. 2011
- Mass Spectrometry Unmasks Mystery Methanococcus Pilin. Journal of Bacteriology. 193:801-803. 2011
- The Peptidoglycan-Binding Protein FimV Promotes Assembly of the Pseudomonas aeruginosa Type IV Pilus Secretin. Journal of Bacteriology. 193:540-550. 2011
- Evolutionary and functional diversity of thePseudomonastype IVa pilin island. Environmental Microbiology. 13:250-264. 2011
- Architecture of the type II secretion and type IV pilus machineries. Future Microbiology. 5:1203-1218. 2010
- Pseudomonas aeruginosa Minor Pilins Are Incorporated into Type IV Pili. Journal of Molecular Biology. 398:444-461. 2010
- AlgK Is a TPR-Containing Protein and the Periplasmic Component of a Novel Exopolysaccharide Secretin. Structure Structure with Folding & design. 18:265-273. 2010
- Structural Characterization of Novel Pseudomonas aeruginosa Type IV Pilins. Journal of Molecular Biology. 395:491-503. 2010
- Periplasmic Domains of Pseudomonas aeruginosa PilN and PilO Form a Stable Heterodimeric Complex. Journal of Molecular Biology. 394:143-159. 2009
- PilM/N/O/P Proteins Form an Inner Membrane Complex That Affects the Stability of the Pseudomonas aeruginosa Type IV Pilus Secretin. Journal of Molecular Biology. 394:128-142. 2009
- Single-Residue Changes in the C-Terminal Disulfide-Bonded Loop of the Pseudomonas aeruginosa Type IV Pilin Influence Pilus Assembly and Twitching Motility. Journal of Bacteriology. 191:6513-6524. 2009
-
Modification of
Pseudomonas aeruginosa
Pa5196 Type IV Pilins at Multiple Sites with
d -Ara f by a Novel GT-C Family Arabinosyltransferase, TfpW. Journal of Bacteriology. 190:7464-7478. 2008 - Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection. Surgery. 144:814-821. 2008
- Novel Proteins That Modulate Type IV Pilus Retraction Dynamics in Pseudomonas aeruginosa. Journal of Bacteriology. 190:7022-7034. 2008
- PilF Is an Outer Membrane Lipoprotein Required for Multimerization and Localization of the Pseudomonas aeruginosa Type IV Pilus Secretin. Journal of Bacteriology. 190:6961-6969. 2008
- Membrane interactions of designed cationic antimicrobial peptides: The two thresholds. Biopolymers. 89:360-371. 2008
- A Nice Return on the “Stalk” Exchange. Structure Structure with Folding & design. 16:19-20. 2008
- Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU. Microbiology. 154:114-126. 2008
- Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome. BJU International. 0:071009190733001-???. 2008
- Category III chronic prostatitis/chronic pelvic pain syndrome: Insights from the National Institutes of Health Chronic Prostatitis Collaborative Research Network studies. Current Prostate Reports. 5:141-148. 2007
- Hydrophobic Interactions in Complexes of Antimicrobial Peptides with Bacterial Polysaccharides. Journal of Peptide Research Peptide Research Chemical Biology and Drug Design. 69:405-412. 2007
- Expression, purification, crystallization and preliminary X-ray analysis ofPseudomonas fluorescensAlgK. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63:415-418. 2007
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Glycosylation of
Pseudomonas aeruginosa
Strain Pa5196 Type IV Pilins with Mycobacterium-Like α-1,5-Linked
d -Ara f Oligosaccharides. Journal of Bacteriology. 189:151-159. 2007 - Laboratory and clinical Pseudomonas aeruginosa strains do not bind glycosphingolipids in vitro or during type IV pili-mediated initial host cell attachment. Microbiology. 152:2789-2799. 2006
- Activity of novel non-amphipathic cationic antimicrobial peptides against Candida species. Journal of Antimicrobial Chemotherapy. 57:899-907. 2006
- Abnormalities in the Pulmonary Innate Immune System in Cystic Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 34:364-374. 2006
- Common β-lactamases inhibit bacterial biofilm formation. Molecular Microbiology Microbiological Sciences. 58:1012-1024. 2005
- Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial Versus Mammalian Membranes. Journal of Biological Chemistry. 280:33960-33967. 2005
- Mycobacterium neoaurumContamination. Emerging Infectious Diseases. 11:1316-1317. 2005
- Mycobacterium neoaurumContamination. Emerging Infectious Diseases. 11:1317-1317. 2005
- Weapons of mass retraction. Molecular Microbiology Microbiological Sciences. 57:878-888. 2005
- Alginate as an auxiliary bacterial membrane: binding of membrane-active peptides by polysaccharides. Journal of Peptide Research Peptide Research Chemical Biology and Drug Design. 65:343-351. 2005
- Alginate as an auxiliary bacterial membrane: binding of membrane-active peptides by polysaccharides*. Journal of Peptide Research Peptide Research Chemical Biology and Drug Design. 65:343-351. 2005
- Disparate Subcellular Localization Patterns of Pseudomonas aeruginosa Type IV Pilus ATPases Involved in Twitching Motility. Journal of Bacteriology. 187:829-839. 2005
- Helix Induction in Antimicrobial Peptides by Alginate in Biofilms. Journal of Biological Chemistry. 279:38749-38754. 2004
- IMPACT OF POST-EJACULATORY PAIN IN MEN WITH CATEGORY III CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME. Investigative Urology. 172:542-547. 2004
- Rapidly Progressive Dementia Due toMycobacterium neoaurumMeningoencephalitis. Emerging Infectious Diseases. 10:924-927. 2004
- Tropheryma whippelii as a cause of afebrile culture-negative endocarditis: the evolving spectrum of Whipple's disease. Journal of Infection. 47:170-173. 2003
- Use of In-Biofilm Expression Technology To Identify Genes Involved in Pseudomonas aeruginosa Biofilm Development. Journal of Bacteriology. 185:2700-2710. 2003
- Biofilm Formation by Hyperpiliated Mutants of Pseudomonas aeruginosa. Journal of Bacteriology. 185:2374-2378. 2003
- Low-Virulence Citrobacter Species Encode Resistance to Multiple Antimicrobials. Antimicrobial Agents and Chemotherapy. 46:3555-3560. 2002
- Demographic And Clinical Characteristics Of Men With Chronic Prostatitis: The National Institutes Of Health Chronic Prostatitis Cohort Study. JOURNAL OF UROLOGY. 168:593-598. 2002
- Colonization-Resistant Antimicrobial-Coated Peritoneal Dialysis Catheters: Evaluation in a Newly Developed Rat Model of Persistent Pseudomonas Aeruginosa Peritonitis. Peritoneal Dialysis International. 22:27-31. 2002
- Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network.. Journal of General Internal Medicine. 16:656-662. 2001
- Molecular mechanisms of cefoxitin resistance in Escherichia coli from the Toronto area hospitals. Diagnostic Microbiology and Infectious Disease. 41:57-63. 2001
- Three-component-mediated serotype conversion in Pseudomonas aeruginosa by bacteriophage D3. Molecular Microbiology Microbiological Sciences. 39:1237-1247. 2001
- Involvement of the rml locus in core oligosaccharide and O polysaccharide assembly in Pseudomonas aeruginosa. Microbiology. 146:2803-2814. 2000
- Pseudomonas aeruginosaB-band lipopolysaccharide geneswbpAandwbpIand theirEscherichia colihomologueswecCandwecBare not functionally interchangeable. FEMS Microbiology Letters. 189:135-141. 2000
- Functional Conservation of the Polysaccharide Biosynthetic Protein WbpM and Its Homologues in Pseudomonas aeruginosa and Other Medically Significant Bacteria. Infection and Immunity. 68:931-936. 2000
- Lipopolysaccharide core phosphates are required for viability and intrinsic drug resistance in Pseudomonas aeruginosa. Molecular Microbiology Microbiological Sciences. 35:718-727. 2000
- Issues surrounding the prevention and management of device-related infections. World Journal of Urology. 17:402-409. 1999
- Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide The GenBank accession number for the sequence reported in this paper is AF035937.. Microbiology. 145:3505-3521. 1999
- Genetics of O-Antigen Biosynthesis in Pseudomonas aeruginosa. Microbiology and Molecular Biology Reviews. 63:523-553. 1999
- Genetic and biochemical characterization of an operon involved in the biosynthesis of 3-deoxy-?-manno-octulosonic acid in Pseudomonas aeruginosa. FEMS Microbiology Letters. 173:27-33. 1999
- Genetic and biochemical characterization of an operon involved in the biosynthesis of 3-deoxy-d-manno-octulosonic acid inPseudomonas aeruginosa. FEMS Microbiology Letters. 173:27-33. 1999
- Effect of wzx ( rfbX ) Mutations on A-Band and B-Band Lipopolysaccharide Biosynthesis in Pseudomonas aeruginosa O5. Journal of Bacteriology. 181:973-980. 1999
- Glycosyltransferases of Pseudomonas aeruginosa that assemble the O antigens of A band and B band lipopolysaccharide. Journal of Endotoxin Research. 5:96-101. 1999
- Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. Molecular Microbiology Microbiological Sciences. 30:1131-1131. 1998
- Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. Molecular Microbiology Microbiological Sciences. 28:1103-1119. 1998
- Pseudomonas aeruginosa B-band O-antigen chain length is modulated by Wzz (Ro1). Journal of Bacteriology. 179:1482-1489. 1997
- Molecular characterization of the Pseudomonas aeruginosa serotype O5 (PAO1) B-band lipopolysaccharide gene cluster. Molecular Microbiology Microbiological Sciences. 22:481-495. 1996
- The kdsA gene of Pasteurella trehalosi (haemolytica) serotype T3 is functionally and genetically homologous to that of Escherichia coli. Journal of Endotoxin Research. 3:353-359. 1996
- Molecular analysis of the leukotoxin determinants from Pasteurella haemolytica serotypes 1 to 16. Infection and Immunity. 61:5001-5007. 1993
- Molecular characterization of an RTX toxin determinant from Actinobacillus suis. Infection and Immunity. 60:2166-2173. 1992
- Pseudomonas aeruginosa FpvB is a high-affinity transporter for xenosiderophores ferrichrome and ferrioxamine B
- Pseudomonas aeruginosatype IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity
- Bacteria defend against phages through type IV pilus glycosylation
- Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics
- CryoEM map ofPseudomonas aeruginosaPilQ enables structural characterization of TsaP
- Forging new antibiotic combinations under iron-limiting conditions
- ThePseudomonas aeruginosaPilSR two-component system regulates both twitching and swimming motilities
- Thiocillin and Micrococcin Exploit the Ferrioxamine Receptor of Pseudomonas aeruginosa for Uptake
- Thiostrepton hijacks pyoverdine receptors to inhibit growth ofPseudomonas aeruginosa
- cAMP-independent control of twitching motility inPseudomonas aeruginosa
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chapter
- The Dynamic Structures of the Type IV Pilus. 113-128. 2019
- Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action. Annual Review of Microbiology. 493-520. 2012
- Infections due to Citrobacter and Enterobacter. 1-12. 2007
- Infections due to Escherichia and Shigella. 1-10. 2007
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conference paper
- The molecular mechanism of the type IVa pilus motor. Acta Crystallographica Section A: Foundations of Crystallography. a164-a164. 2018
- Response of the Murine Urinary Bladder Microcirculation to Lipopolysaccharide from Escherichia coli and Pseudomonas aeruginosa. FASEB Journal. 2010
- Intravital Microscopy of the Murine Urinary Bladder Microcirculation. FASEB Journal. 2009
- Mechanical Properties of Type IV Pili in Pseudomonas Aeruginosa. Biophysical Journal. 641a-642a. 2009
- Characterization of PilP, a protein required for the assembly of Pseudomonas aeruginosa type IV pili. FEBS Journal European Journal of Biochemistry. 206-206. 2008
- Deciphering the role of PilF in Pseudomonas aeruginosa type IV pilus biogenesis. FEBS Journal European Journal of Biochemistry. 271-271. 2008
- Investigating the roles of PilMNO proteins in P-aeruginosa type IV pilus assembly. FEBS Journal European Journal of Biochemistry. 129-129. 2007
- Structural studies of AlgK: a lipoprotein required for alginate biosynthesis in Pseudomonas aeruginosa. FEBS Journal European Journal of Biochemistry. 109-109. 2007
- Structure-function studies of Pseudomonas aeruginosa type IV pilus cell-wall scaffold proteins. Biochemistry and Cell Biology. 1076-1076. 2006
- Significant differences in type IV pilin allele distribution among Pseudomonas aeruginosa isolates from cystic fibrosis (CF) versus non-CF patients. Microbiology. 1315-1326. 2004
- Novel type IV pilin structural and accessory genes in Pseudomonas.. Critical Reviews in Oral Biology and Medicine Journal of Dental Research. B284-B284. 2003
- Contamination of Bone Marrow Products with an Actinomycete ResemblingMicrobacteriumSpecies and Reinfusion into Autologous Stem Cell and Bone Marrow Transplant Recipients. Clinical Infectious Diseases. e115-e121. 2003
- Is Surveillance for Multidrug‐Resistant Enterobacteriaceae an Effective Infection Control Strategy in the Absence of an Outbreak?. Journal of Infectious Diseases. 1754-1760. 2002