Forging New Antibiotic Combinations under Iron-Limiting Conditions Journal Articles

abstract

• Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical isolates. A small number of P. aeruginosa and A. baumannii isolates were resistant to the combination, prompting us to search for other compounds that could synergize with TS against those strains.

authors

• Chan, Derek CK
• Guo, Irene
• Burrows, Lori

status

• published 

publication date

• February 21, 2020

has subject area

• 0605 Microbiology (FoR)
• 1108 Medical Microbiology (FoR)
• 1115 Pharmacology and Pharmaceutical Sciences (FoR)
• Acinetobacter baumannii (MeSH)
• Anti-Bacterial Agents (MeSH)
• Ciclopirox (MeSH)
• Clioquinol (MeSH)
• Doxycycline (MeSH)
• Gallium (MeSH)
• Iron (MeSH)
• Iron Deficiencies (MeSH)
• Microbial Sensitivity Tests (MeSH)
• Microbiology (Science Metrix)
• Pseudomonas aeruginosa (MeSH)
• Tropolone (MeSH)

published in

• Antimicrobial Agents and Chemotherapy  Journal

keywords

• Acinetobacter baumannii
• Anti-Bacterial Agents
• Ciclopirox
• Clioquinol
• Doxycycline
• Gallium
• Iron
• Iron Deficiencies
• Microbial Sensitivity Tests
• Pseudomonas aeruginosa
• Tropolone
• chelator
• iron
• thiostrepton

Digital Object Identifier (DOI)

• 10.1128/aac.01909-19

start page

• e01909

end page

• e01919

volume

• 64

issue

• 3