Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa Journal Articles uri icon

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  • Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen and is intrinsically resistant to many antibiotics. In a high-throughput screen for molecules that modulate biofilm formation, we discovered that the thiopeptide antibiotic thiostrepton (TS), which is considered to be inactive against Gram-negative bacteria, stimulated P. aeruginosa biofilm formation in a dose-dependent manner.


  • Ranieri, Michael RM
  • Chan, Derek CK
  • Yaeger, Luke N
  • Rudolph, Madeleine
  • Karabelas-Pittman, Sawyer
  • Abdo, Hamdi
  • Chee, Jessica
  • Harvey, Hanjeong
  • Nguyen, Uyen
  • Burrows, Lori

publication date

  • September 2019

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