Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa Journal Articles

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abstract

Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen and is intrinsically resistant to many antibiotics. In a high-throughput screen for molecules that modulate biofilm formation, we discovered that the thiopeptide antibiotic thiostrepton (TS), which is considered to be inactive against Gram-negative bacteria, stimulated P. aeruginosa biofilm formation in a dose-dependent manner.

authors

Ranieri, Michael RM
Chan, Derek CK
Yaeger, Luke N
Rudolph, Madeleine
Karabelas-Pittman, Sawyer
Abdo, Hamdi
Chee, Jessica
Harvey, Hanjeong
Nguyen, Uyen
Burrows, Lori

status

published

publication date

September 2019

has subject area

0605 Microbiology (FoR)
1108 Medical Microbiology (FoR)
1115 Pharmacology and Pharmaceutical Sciences (FoR)
Acinetobacter baumannii (MeSH)
Anti-Bacterial Agents (MeSH)
Bacterial Outer Membrane Proteins (MeSH)
Bacterial Proteins (MeSH)
Biofilms (MeSH)
Dose-Response Relationship, Drug (MeSH)
Drug Resistance, Multiple, Bacterial (MeSH)
Iron Chelating Agents (MeSH)
Membrane Proteins (MeSH)
Microbial Sensitivity Tests (MeSH)
Microbiology (Science Metrix)
Mutation (MeSH)
Pseudomonas aeruginosa (MeSH)
Thiostrepton (MeSH)

published in

Antimicrobial Agents and Chemotherapy Journal