A New Twist in the Assembly of Type IV Pilus-like Fibers
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The type II secretion system (T2SS) and the type IV pilus system (T4PS) are structurally related molecular machines that reversibly assemble helical fibers in an ATP-dependent manner. In this issue of Structure, Nivaskumar and colleagues provide support for a "spooling" model of T2SS pseudopilus assembly and suggest that the T2S-and by extension, T4P-system motors may operate in a rotary manner to assemble filaments.
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