Journal article
PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM*
Abstract
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that expresses type IVa pili. The pilus assembly system, which promotes surface-associated twitching motility and virulence, is composed of inner and outer membrane subcomplexes, connected by an alignment subcomplex composed of PilMNOP. PilM binds to the N terminus of PilN, and we hypothesize that this interaction causes functionally significant structural changes in PilM. To …
Authors
McCallum M; Tammam S; Little DJ; Robinson H; Koo J; Shah M; Calmettes C; Moraes TF; Burrows LL; Howell PL
Journal
Journal of Biological Chemistry, Vol. 291, No. 21, pp. 11003–11015
Publisher
Elsevier
Publication Date
May 2016
DOI
10.1074/jbc.m116.718353
ISSN
0021-9258