Journal article
Exploration of BAY 11-7082 as a Potential Antibiotic
Abstract
Exposure of the Gram-negative pathogen Pseudomonas aeruginosa to subinhibitory concentrations of antibiotics increases the formation of biofilms. We exploited this phenotype to identify molecules with potential antimicrobial activity in a biofilm-based high-throughput screen. The anti-inflammatory compound BAY 11-7082 induced dose-dependent biofilm stimulation, indicative of antibacterial activity. We confirmed that BAY 11-7082 inhibits the …
Authors
Coles VE; Darveau P; Zhang X; Harvey H; Henriksbo BD; Yang A; Schertzer JD; Magolan J; Burrows LL
Journal
ACS Infectious Diseases, Vol. 8, No. 1, pp. 170–182
Publisher
American Chemical Society (ACS)
Publication Date
January 14, 2022
DOI
10.1021/acsinfecdis.1c00522
ISSN
2373-8227